OXOMEMAZINE

Product Name: OXOMEMAZINE
CAS No.: 3689-50-7
Chemical Name: OXOMEMAZINE
Synonyms: Imakol;6847 RP;6487 RP;Dysedon;RP-6847;Doxergan;Dosegran;6847 R.P.;Oxomemazin;OXOEMAZINE
CBNumber: CB1236273
Molecular Formula: C18H22N2O2S
Formula Weight: 330.44
MOL File: 3689-50-7.mol

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OXOMEMAZINE Property

Melting point:: 115°
Boiling point:: 492.4±34.0 °C(Predicted)
Density: 1.1453 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: Store at -20°C
solubility: ≥ 33mg/mL in DMSO
form: Solid
pka: 9.31±0.28(Predicted)
color: White to off-white

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Safety

Toxicity: LD50 oral in mouse: 140mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P310Immediately call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: O860005
Product name: (±)-Oxomemazine
Packaging: 1g
Price: $920
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009875
Product name: OXOMEMAZINE
Purity: 95.00%
Packaging: 1G
Price: $892.5
Updated: 2021/12/16

ChemScene

Product number: CS-0131898
Product name: Oxomemazine
Packaging: 10mg
Price: $60
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009875
Product name: OXOMEMAZINE
Purity: 95.00%
Packaging: 5MG
Price: $502.11
Updated: 2021/12/16

Crysdot

Product number: CD11134460
Product name: Oxomemazine
Purity: 97%
Packaging: 1g
Price: $680
Updated: 2021/12/16

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OXOMEMAZINE Chemical Properties,Usage,Production

Originator

Doxergan,Specia,France,1964

Uses

(±)-Oxomemazine, is a phenothiazine-type antihistamines, that has also shown antibacterial activity against Mycobacterium tuberculosis.

Definition

ChEBI: Oxomemazine is a member of phenothiazines.

Manufacturing Process

Phenothiazine is reacted with 3-dimethylamino-2-methylpropyl chloride in the presence of sodium amide to give 3-(10-phenthiazinyl)-2-methyl-1dimethylaminopropane. 11.9 g of of this intermediate is dissolved with agitation in glacial acetic acid (120 cc). Pure sulfuric acid (d = 1.83; 0.5 cc) is added and a mixture of glacial acetic acid (10 cc) and hydrogen peroxide (8.5 cc of a solution containing 38 g of hydrogen peroxide in 100 cc) is then run in over 20 minutes. The temperature rises from 25°C to 35°C and is then kept at 60°C for 18 hours. The mixture is cooled and water (150 cc) is added and, with cooling, aqueous sodium hydroxide (d = 1.33; 220 cc). The resulting mixture is extracted with ethyl acetate (3 x 100 cc), the solvent is evaporated on a water bath and the residue is recrystallized from heptane (150 cc). 3(9,9-dioxy-10-phenthiazinyl)-2-methyl-1-dimethylaminopropane (78 g) is obtained, MP 115°C.
The corresponding hydrochloride prepared in ethyl acetate and recrystallized from a mixture of ethanol and isopropanol melts at 250°C.

Therapeutic Function

Antihistaminic

OXOMEMAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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OXOMEMAZINE Suppliers

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View Lastest Price from OXOMEMAZINE manufacturers

Hebei Mingeng Biotechnology Co., Ltd

Product: Oxomemazine 3689-50-7
Price: US $200.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg/Month
Release date: 2022-11-23

Shijiazhuang Gantuo Biotechnology Co., Ltd

Product: Oxomemazine 3689-50-7
Price: US $100.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 1000g
Release date: 2023-03-10

3689-50-7, OXOMEMAZINERelated Search:

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OXOMEMAZINE

10-(3-(Dimethylamino)-2-methylpropyl)phenothiazine-5,5-dioxide

10H-Phenothiazine-10-propanamine, N,N,beta-trimethyl-, 5,5-dioxide

3-(5,5-Dioxido-10H-phenothiazin-10-yl)-N,N,2-trimethyl-1-propanamine

6487 RP

6847 R.P.

6847 RP

Alimemazine S,S-dioxide

Dosegran

Doxergan

Dysedon

Imakol

Oxomemazin

Oxymemazine

Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-, 5,5-dioxide

RP-6847

S,S-Dioxo-9,9-(dimethylamino-3-methyl-2-propyl)-10-phenothiazine

Trimeprazine 5,5-dioxide

Oxomemazinebase

Oxomenazine

OXOEMAZINE

10-(3-Dimethylamino-2-methylpropyl)-10H-phenothiazine 5,5-dioxide

10-[2-(Dimethylaminomethyl)propyl]-10H-phenothiazine 5,5-dioxide

N,N,β-Trimethyl-10H-phenothiazine-10-propan-1-amine 5,5-dioxide

[3-(5,5-diketophenothiazin-10-yl)-2-methyl-propyl]-dimethyl-amine

3-(5,5-dioxophenothiazin-10-yl)-N,N,2-trimethyl-propan-1-amine

3-(5,5-dioxophenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine

10H-Phenothiazine-10-propanamine, N,N,β-trimethyl-, 5,5-dioxide

OxomemazineQ: What is Oxomemazine Q: What is the CAS Number of Oxomemazine Q: What is the storage condition of Oxomemazine Q: What are the applications of Oxomemazine

histamine H1-receptor,OXOMEMAZINE,Histamine Receptor,inhibit,phenothiazine,antimuscarinic,muscarinic M1,Inhibitor,Metabotropic glutamate receptors,cough,anticholinergic,antihistamine,mGluR

3689-50-7