2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide monohydrochloride Property

Melting point:

192-193 °C

Density 

1.371 g/cm3

storage temp. 

Store at -20°C

solubility 

insoluble in EtOH; ≥14.55 mg/mL in DMSO; ≥57.5 mg/mL in H2O

form 

A crystalline solid

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide monohydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A phenylalkanolamine derivative which has been found to be effective in treating hypertensive conditions due to their long lasting blood pressure increasing effects.

Definition

ChEBI: Midodrine hydrochloride is a hydrochloride resulting from the combination of equimolar amounts of midodrine and hydrogen chloride. Midodrine is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. The hydrochloride salt is used as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine. It has a role as an alpha-adrenergic agonist, a sympathomimetic agent and a vasoconstrictor agent. It contains a midodrine(1+).

Biological Activity

ki: 2, 6.9, and 1.7 μm for α1a, α1b, α1d, respectivelymidodrine is the prodrug of the α1-adrenergic receptor agonist, 1-(2’,5’-dimethoxyphenyl)-2-aminoethanol.the α1-adrenergic receptor has some general functions similar with the α2-adrenergic receptor, but also has its own specific effects. α1-receptors primarily can mediate smooth muscle contraction and have other important functions as well.

in vitro

midodrine was identified as a prodrug forming an active metabolite, desglymidodrine, which is an α1-receptor agonist exerting its actions through activation of the alpha-adrenergic receptors of the arteriolar and venous vasculature, leading to an increased vascular tone and elevation of blood pressure [1].

in vivo

a previous study was conducted to investigate the effect of intracerebroventricular injections of midodrine on the central nervous system of the rat. it was found that midodrine could decrease body temperature and increase locomotor activity, sedation in reserpinized rats as well as the cataleptic effect of haloperidol. midodrine could also enhance amphetamine-stimulated locomotor activity and reduce the amphetamine and apomorphine sterotypy [1].

References

[1] kleinrok z, jagieo-wójtowicz e, oktaba-polkowska a. central action of intraventricularly-injected midodrine in rats. arch int pharmacodyn ther. 1980 oct;247(2):217-33.
[2] rai n, singh b, singh a, vijayvergiya r, sharma n, bhalla a, singh v. midodrine and tolvaptan in patients with cirrhosis and refractory or recurrent ascites: a randomised pilot study. liver int. 2017 mar;37(3):406-414.