ChemicalBook > CAS DataBase List > 2-bromo-5-hydroxybenzoic acid

2-bromo-5-hydroxybenzoic acid

Product Name
2-bromo-5-hydroxybenzoic acid
CAS No.
58380-11-3
Chemical Name
2-bromo-5-hydroxybenzoic acid
Synonyms
Benzoic acid, 2-bromo-5-hydroxy-;2-Bromo-5-HydroxybenzoicAci;2-BROMO-5-HYDROXYBENZOIC ACID;2-Bromo-5-Hydroxyphenylboronic Acid
CBNumber
CB5947193
Molecular Formula
C7H5BrO3
Formula Weight
217.02
MOL File
58380-11-3.mol
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2-bromo-5-hydroxybenzoic acid Property

Melting point:
185 °C (decomp)
Boiling point:
374.5±32.0 °C(Predicted)
Density 
1.861±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
2.73±0.10(Predicted)
form 
powder
color 
White
InChI
InChI=1S/C7H5BrO3/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3,9H,(H,10,11)
InChIKey
HTCSAMJZDHWTKD-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC(O)=CC=C1Br
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Safety

HS Code 
2916310090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

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N-Bromosuccinimide Price

TRC
Product number
B619405
Product name
2-Bromo-5-hydroxybenzoicacid
Packaging
10g
Price
$400
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB55614
Product name
2-Bromo-5-hydroxybenzoic acid
Packaging
25g
Price
$350
Updated
2021/12/16
Apolloscientific
Product number
OR400079
Product name
2-Bromo-5-hydroxybenzoicacid
Packaging
25g
Price
$392
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB55614
Product name
2-Bromo-5-hydroxybenzoic acid
Packaging
10g
Price
$162.5
Updated
2021/12/16
SynQuest Laboratories
Product number
2629-9-18
Product name
2-Bromo-5-hydroxybenzoic acid
Packaging
5G
Price
$176
Updated
2021/12/16
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2-bromo-5-hydroxybenzoic acid Chemical Properties,Usage,Production

Uses

2-Bromo-5-Hydroxyphenylboronic Acid serves as a reagent in the synthesis and biological activities of some new dibenzopyranones and dibenzopyrans as estrogen receptor agonists and antagonists in relation to anti-osteoporotic and anti-uterotropic and anti-implantation activities

Synthesis

22921-68-2

58380-11-3

General procedure for the synthesis of 2-bromo-5-hydroxybenzoic acid from 2-bromo-5-methoxybenzoic acid: 5 g of 2-bromo-5-methoxybenzoic acid (purchased from Wako Pure Chemical Industries, Ltd.) was refluxed with 15 g of aluminum chloride in 150 mL of chlorobenzene for 2.5 hours. After completion of the reaction, the reaction mixture was cooled and poured into ice water. The aqueous phase was extracted three times with 250 mL of diethyl ether. The organic phases were combined and concentrated under reduced pressure to remove the solvent to give 4.2 g of 2-bromo-5-hydroxybenzoic acid. Subsequently, 3.9 g of the resulting 2-bromo-5-hydroxybenzoic acid was dissolved with 3.9 g of resorcinol (purchased from Tokyo Chemical Industry Co., Ltd.) in 9 mL of aqueous 4M NaOH and heated at 60 °C for 30 min. To the reaction solution, 1.8 mL of 10% copper sulfate aqueous solution was added and heating was continued for 10 min. At the end of the reaction, the precipitate formed was collected by filtration to obtain a white powder of Urea A.

References

[1] Yakugaku Zasshi, 1956, vol. 76, p. 1122,1125
[2] Chem.Abstr., 1957, p. 3505
[3] Journal of Medicinal Chemistry, 2002, vol. 45, # 12, p. 2388 - 2409
[4] Patent: US5519133, 1996, A
[5] Journal of Agricultural and Food Chemistry, 2008, vol. 56, # 2, p. 393 - 400

2-bromo-5-hydroxybenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-bromo-5-hydroxybenzoic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-bromo-5-hydroxybenzoic acid 58380-11-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-06
Anhui Ruihan Technology Co., Ltd
Product
2-bromo-5-hydroxybenzoic acid 58380-11-3
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2023-09-08
Career Henan Chemical Co
Product
2-bromo-5-hydroxybenzoic acid 58380-11-3
Price
US $1.00/KG
Min. Order
1KG
Purity
98%-100%
Supply Ability
1
Release date
2018-08-12

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  • 2-Bromo-5-Hydroxyphenylboronic Acid
  • Benzoic acid, 2-bromo-5-hydroxy-
  • 2-Bromo-5-HydroxybenzoicAci
  • 2-BROMO-5-HYDROXYBENZOIC ACID
  • 58380-11-3