METHYL 2-BROMO-5-METHOXYBENZOATE
- Product Name
- METHYL 2-BROMO-5-METHOXYBENZOATE
- CAS No.
- 35450-36-3
- Chemical Name
- METHYL 2-BROMO-5-METHOXYBENZOATE
- Synonyms
- RARECHEM AL BF 1111;Methyl 6-Bromo-m-anisate;METHYL 2-BROMO-5-METHOXYBENZOATE;2-bromo-5-methoxy methylbenzoate;2-bromo-5-methoxy-3-methylbenzoate;6-Bromo-m-anisic Acid Methyl Ester;Methyl2-Bromo-5-methoxybenzoate>Methyl 2-bromo-5-methoxybenzoate 97%;Methyl 2-bromo-5-methoxybenzoate-98%;Methyl 2-bromo-5-methoxybenzoate, 97%
- CBNumber
- CB7252824
- Molecular Formula
- C9H9BrO3
- Formula Weight
- 245.07
- MOL File
- 35450-36-3.mol
METHYL 2-BROMO-5-METHOXYBENZOATE Property
- Boiling point:
- 271 °C
- Density
- 1.520 g/mL at 25 °C
- refractive index
- n20/D 1.563
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- color
- Colorless to Light yellow to Light orange
- Water Solubility
- Not miscible in water.
- BRN
- 2641378
- CAS DataBase Reference
- 35450-36-3(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- 659290
- Product name
- Methyl 2-bromo-5-methoxybenzoate
- Purity
- 97%
- Packaging
- 5g
- Price
- $37.71
- Updated
- 2025/07/31
- Product number
- 659290
- Product name
- Methyl 2-bromo-5-methoxybenzoate
- Purity
- 97%
- Packaging
- 25g
- Price
- $103.6
- Updated
- 2025/07/31
- Product number
- M1934
- Product name
- Methyl 2-Bromo-5-methoxybenzoate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $32
- Updated
- 2025/07/31
- Product number
- M1934
- Product name
- Methyl 2-Bromo-5-methoxybenzoate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $110
- Updated
- 2025/07/31
- Product number
- M258705
- Product name
- Methyl 2-Bromo-5-methoxybenzoate
- Packaging
- 10g
- Price
- $85
- Updated
- 2021/12/16
METHYL 2-BROMO-5-METHOXYBENZOATE Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Uses
Methyl 2-bromo-5-methoxybenzoate is used as pharmaceutical intermediate.
Synthesis
67-56-1
22921-68-2
35450-36-3
To a stirred solution of 2-bromo-5-methoxybenzoic acid (5.0 g, 21.6 mmol) in methanol (80 mL) was slowly added concentrated hydrochloric acid (2 mL). The reaction mixture was heated to reflux and stirred continuously for 18 hours. Upon completion of the reaction, the solution was cooled to room temperature and the solvent was subsequently evaporated under reduced pressure. Water (100 mL) was added to the residue and extracted with ethyl acetate (2 x 100 mL). The organic phases were combined and washed with saturated aqueous sodium bicarbonate to remove unreacted acid. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated to give methyl 2-bromo-5-methoxybenzoate as a light brown oil (4.50 g, 85% yield). The product was confirmed by NMR hydrogen spectrum (300 MHz, CDCl3): δH 7.53 (1H, d, J=8.8 Hz, 3-H), 7.32 (1H, d, J=3.0 Hz, 6-H), 6.89 (1H, dd, J=3.0, 8.8 Hz, 4-H), 3.94 (3H, s, ArOCH3), 3.82 (3H, s. CO2CH3). Infrared spectroscopy (thin-film method) showed characteristic absorption peaks: 2951, 1732 (C=O), 1592, 1472, 1433, 1289, 1250, 1227, 1099, 1017, 975, 823, 792 cm-1. Thin-layer chromatography (unfolding reagent: hexane-ethyl acetate, 5:1) showed Rf-value of 0.58. All the data are in agreement with the literature reports ( Barhate, NB; Gajare, AS; Wakharkar, RD; Bedekar, AV Tetrahedron 1999,55,11127-11142).
References
[1] Tetrahedron, 1998, vol. 54, # 37, p. 11209 - 11234
[2] Journal of Organic Chemistry, 2003, vol. 68, # 11, p. 4586 - 4589
[3] Patent: WO2012/102985, 2012, A1. Location in patent: Page/Page column 111
[4] Patent: WO2008/75048, 2008, A2. Location in patent: Page/Page column 64-65
[5] Tetrahedron, 1995, vol. 51, # 37, p. 10115 - 10124
METHYL 2-BROMO-5-METHOXYBENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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