5-Chloro-1-tetralone
- Product Name
- 5-Chloro-1-tetralone
- CAS No.
- 26673-30-3
- Chemical Name
- 5-Chloro-1-tetralone
- Synonyms
- 5-Chloro-tetral-1-on;5-Chloro-α-Tetralone;5-Chloro-1-tetralone;5-chlorotetralin-1-one;5-CHLORO-1-TETRALONEAMOT0705;5-Chloro-3,4-dihydronaphthalen-1(2H);5-chloro-3,4-dihydronaphthalen-1(2H)-one;1(2H)-Naphthalenone, 5-chloro-3,4-dihydro-;5-Chloro-3,4-dihydronaphthalene-1 (2H) - one
- CBNumber
- CB5948231
- Molecular Formula
- C10H9ClO
- Formula Weight
- 180.63
- MOL File
- 26673-30-3.mol
5-Chloro-1-tetralone Property
- Melting point:
- 65.5-67 °C
- Boiling point:
- 306.2±31.0 °C(Predicted)
- Density
- 1.248±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
Safety
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- X3528
- Product name
- 5-Chloro-1-tetralone
- Packaging
- 1g
- Price
- $251
- Updated
- 2021/12/16
- Product number
- HCH0036859
- Product name
- 5-CHLORO-1-TETRALONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $266.7
- Updated
- 2021/12/16
- Product number
- X3528
- Product name
- 5-Chloro-1-tetralone
- Packaging
- 5g
- Price
- $851
- Updated
- 2021/12/16
- Product number
- A104491
- Product name
- 5-Chloro-3,4-dihydronaphthalen-1(2H)-one
- Purity
- 95%
- Packaging
- 10g
- Price
- $1170
- Updated
- 2021/12/16
- Product number
- CM239860
- Product name
- 5-Chloro-3,4-dihydronaphthalen-1(2H)-one
- Purity
- 95%
- Packaging
- 5g
- Price
- $426
- Updated
- 2021/12/16
5-Chloro-1-tetralone Chemical Properties,Usage,Production
Synthesis
41823-28-3
26673-30-3
The general procedure for the synthesis of 5-chloro-3,4-dihydronaphthalen-1(2H)-one from 5-amino-3,4-dihydro-2H-1-naphthalenone was as follows: 5-amino-3,4-dihydronaphthalen-1(2H)-one (1 g, 6.2 mmol) was dissolved in a mixture of HCl (36%, 2 mL) and EtOH (8 mL) at 0 °C, and NaNO2 was slowly added aqueous solution (0.582 g, 8.4 mmol dissolved in 1 mL of water) and stirred for 15 min. Subsequently, the reaction mixture was added dropwise to a solution of CuCl (0.3 g, 3.1 mmol) in HCl (36%, 10 mL) that was preheated to 95 °C and kept at that temperature for 15 minutes. Upon completion of the reaction, the solution was cooled to room temperature, diluted with water and extracted with EtOAc. The organic phases were combined, washed with saturated NaHCO3 solution, dried over MgSO4, filtered and purified by silica gel column chromatography with 40-50% EtOAc/hexane as eluent. The target product 5-chloro-3,4-dihydronaphthalen-1(2H)-one (0.7 g, 62% yield) was finally obtained. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.53 (dd, J = 7.8, 1.2 Hz, 1H), 7.14 (tt, J = 7.8, 0.7 Hz, 1H), 6.88 (dd, J = 7.8, 1.2 Hz, 1H), 3.70 (s, 2H), 2.69 (t, J = 6.2 Hz, 2H), and 2.66-2.60 (m, 2H), 2.30-2.07 (m, 2H).
References
[1] Patent: WO2017/106624, 2017, A1. Location in patent: Paragraph 00141
5-Chloro-1-tetralone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Chloro-1-tetralone manufacturers
- Product
- 5-Chloro-1-tetralone 26673-30-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-Chloro-1-tetralone 26673-30-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 5-Chloro-1-tetralone 26673-30-3
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-14