7-Chloro-1-tetralone
Uses- Product Name
- 7-Chloro-1-tetralone
- CAS No.
- 26673-32-5
- Chemical Name
- 7-Chloro-1-tetralone
- Synonyms
- 7-chloro-3,4-dihydronaphthalen-1(2H)-one;7-chloro-3;7-CHLORO-1-TETRALONE;7-Chloro-α-Tetralone;7-Chloro-1-tetralone >7-Chloro-3,4-dihydro-2H-phthalen-1-one;7-CHLORO-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE;1(2H)-Naphthalenone, 7-chloro-3,4-dihydro-;7-chloro-1,2,3,4-tetrahydronaphthalen-1-one;4-benzoyl-3H-benzo[f]quinoline-3-carbonitrile
- CBNumber
- CB1364868
- Molecular Formula
- C10H9ClO
- Formula Weight
- 180.63
- MOL File
- 26673-32-5.mol
7-Chloro-1-tetralone Property
- Melting point:
- 93.0 to 97.0 °C
- Boiling point:
- 115°C/0.3mmHg(lit.)
- Density
- 1.248±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Toluene
- form
- powder to crystal
- color
- White to Yellow to Green
- λmax
- 305nm(MeOH)(lit.)
- InChI
- InChI=1S/C10H9ClO/c11-8-5-4-7-2-1-3-10(12)9(7)6-8/h4-6H,1-3H2
- InChIKey
- IIMAYXKDBHTQHC-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=CC(Cl)=C2)CCC1
- CAS DataBase Reference
- 26673-32-5
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C2976
- Product name
- 7-Chloro-1-tetralone
- Purity
- >95.0%(GC)
- Packaging
- 1g
- Price
- $40
- Updated
- 2025/07/31
- Product number
- C2976
- Product name
- 7-Chloro-1-tetralone
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $203
- Updated
- 2025/07/31
- Product number
- C429313
- Product name
- 7-Chloro-1-tetralone
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C429313
- Product name
- 7-Chloro-1-tetralone
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 119098
- Product name
- 7-Chloro-1-tetralone
- Purity
- 95+%
- Packaging
- 1g
- Price
- $180
- Updated
- 2021/12/16
7-Chloro-1-tetralone Chemical Properties,Usage,Production
Uses
7-Chloro-1-tetralone (cas# 26673-32-5) is a useful research chemical.
Chemical Properties
Pale yellow to white crystalline powder
Synthesis
4619-18-5
26673-32-5
General procedure for the synthesis of 7-chloro-3,4-dihydro-2H-1-naphthalenone from 4-(4-chlorophenyl)butyric acid: polyphosphoric acid (20 g, excess) was placed in a beaker and heated to 90 °C. 4-(4-Chlorophenyl)butyric acid (3 g, 17 mmol) was added in batches. The reaction mixture was stirred for 5 minutes and then polyphosphoric acid (20 g, excess) was added and continued to be heated at 90°C for 5 minutes. The resulting thick orange viscous oil was cooled to 60 °C, followed by the slow addition of water. After completion of the reaction, the mixture was cooled to room temperature and extracted with ethyl acetate (EtOAc). The organic phase was washed sequentially with water, 1N NaOH solution and water, dried with anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to give a white solid product (2.5 g, 81% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 2.12-2.18 (m, 2H), 2.67 (t, J = 6.8 Hz, 2H), 2.95 (t, J = 6.8 Hz, 2H), 7.22 (d, J = 8.0 Hz, 1H), 7.42 (dd, J = 10.2, 2.4 Hz, 1H), 7.85 (d , J = 2.4 Hz, 1H).
References
[1] Angewandte Chemie - International Edition, 2017, vol. 56, # 41, p. 12476 - 12480
[2] Angew. Chem., 2017, vol. 129, p. 12650 - 12654,5
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 21, p. 6768 - 6781
[4] Patent: WO2017/150904, 2017, A1. Location in patent: Paragraph 312-314
[5] Synthetic Communications, 1991, vol. 21, # 8-9, p. 981 - 987
7-Chloro-1-tetralone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-Chloro-1-tetralone manufacturers
- Product
- 7-Chloro-1-tetralone 26673-32-5
- Price
- US $17.00-152.00/g
- Min. Order
- 10g
- Purity
- 0.98
- Supply Ability
- 25kg
- Release date
- 2024-10-25
- Product
- 7-Chloro-1-tetralone 26673-32-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 100kgs/month
- Release date
- 2021-11-15
- Product
- 7-chloro-3,4-dihydro-2H-naphthalen-1-one 26673-32-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.5%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14