SB269970 HCl
- Product Name
- SB269970 HCl
- CAS No.
- 261901-57-9
- Chemical Name
- SB269970 HCl
- Synonyms
- SB-269970A;SB269970 HCl USP/EP/BP;SB269970 HClSB269970 HCl;SB-269970A|||SB269970 HCl;SB269970 HCl (SB-269970A);SB269970 hydrochloride, >=98%;SB 269970 hydrochloride, 5-HT7 receptor antagonist;(r)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride;(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol hydrochloride;Phenol, 3-[[(2R)-2-[2-(4-methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]-, hydrochloride (1:1)
- CBNumber
- CB5972915
- Molecular Formula
- C18H28N2O3SHCl
- Formula Weight
- 0
- MOL File
- 261901-57-9.mol
SB269970 HCl Property
- storage temp.
- 2-8°C
- solubility
- H2O: soluble10mg/mL, clear (warmed to 60 °C)
- form
- powder
- color
- White to off-white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- S7389
- Product name
- SB-269970 hydrochloride
- Purity
- powder, ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $353
- Updated
- 2024/03/01
- Product number
- S7389
- Product name
- SB-269970 hydrochloride
- Purity
- powder, ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $1230
- Updated
- 2024/03/01
- Product number
- 5.06415
- Product name
- SB-269970 Hydrochloride - CAS 261901-57-9 - Calbiochem
- Packaging
- 10MG
- Price
- $196
- Updated
- 2023/06/20
- Product number
- 17081
- Product name
- SB-269970 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 17081
- Product name
- SB-269970 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $184
- Updated
- 2024/03/01
SB269970 HCl Chemical Properties,Usage,Production
Description
The transduction of neurobehavioral effects by serotonin (5-hydroxy tryptamine; 5-HT) is mediated by at least seven major 5-HT receptor subtypes. SB-269970 is a potent 5-HT7A antagonist (pKi = 8.9) that demonstrates >50-fold binding selectivity over 5-HT5A and >250-fold selectivity over 5-HT1, 5-HT2, 5-HT4, 5-HT6, adrenergic α1, dopamine D2, and dopamine D3 receptors. It is also reported to block adrenergic α2 receptors in guinea pig vas deferens. SB-269970 has been used to target the 5-HT7 receptor in the study of schizophrenia-like cognitive deficits.
Uses
SB 269970A is a selective 5-HT7 receptor antagonist.
General Description
A selective 5-HT7 receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7 receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7 antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B).
Biochem/physiol Actions
Primary Target5-HT
storage
+4°C
References
[1] hagan j j, price g w, jeffrey p, et al. characterization of sb-269970-a, a selective 5-ht7 receptor antagonist. british journal of pharmacology, 2000, 130(3): 539-548.
SB269970 HCl Preparation Products And Raw materials
Raw materials
Preparation Products
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