RILMENIDINE HEMIFUMARATE SALT

Product Name: RILMENIDINE HEMIFUMARATE SALT
CAS No.: 207572-68-7
Chemical Name: RILMENIDINE HEMIFUMARATE SALT
Synonyms: LZFATBMLSYHRTC-WXXKFALUSA-N;RILMENIDINE HEMIFUMARATE SALT;n-(dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine hemifumarate salt;Oxaminozoline hemifumarate salt, Rilmenidene hemifumarate salt, N-(Dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine hemifumarate salt
CBNumber: CB5972920
Molecular Formula: 2C10H16N2O.C4H4O4
Formula Weight: 476.57
MOL File: 207572-68-7.mol

More

Less

RILMENIDINE HEMIFUMARATE SALT Property

storage temp.: Store at -20°C
solubility: DMSO: >10mg/mL
form: solid
color: white

More

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: RP7207400

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R134
Product name: Rilmenidine hemifumarate salt
Purity: solid
Packaging: 5mg
Price: $148
Updated: 2024/03/01

Sigma-Aldrich

Product number: R134
Product name: Rilmenidine hemifumarate salt
Purity: solid
Packaging: 25mg
Price: $562
Updated: 2024/03/01

Cayman Chemical

Product number: 16988
Product name: Rilmenidine (hemifumarate)
Purity: ≥98%
Packaging: 1mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 16988
Product name: Rilmenidine (hemifumarate)
Purity: ≥98%
Packaging: 5mg
Price: $98
Updated: 2024/03/01

Cayman Chemical

Product number: 16988
Product name: Rilmenidine (hemifumarate)
Purity: ≥98%
Packaging: 10mg
Price: $161
Updated: 2024/03/01

More

Less

RILMENIDINE HEMIFUMARATE SALT Chemical Properties,Usage,Production

Uses

Rilmenidine hemifumarate ┬аis an antihypertensive agent that selectively binds nonadrenergic imidazoline-binding site I1 receptor.

Biological Activity

rilmenidine is an antihypertensive agent that has been shown to lower arterial pressure in various animal models by inhibiting the tonic activity of sympathoexcitatory neurons in the rostral ventrolateral medulla [1].

Biochem/physiol Actions

Selective I1 imidazoline receptor agonist.

in vitro

bilateral microinjection of rilmenidine into the c1 area of the rostral ventrolateral medulla (rvl) elicited dose-dependent falls in arterial pressure and heart rate. in rvl, rilmenidine competed with binding to imidazole and α2-adrenergic binding sites with a 30-fold selectivity for the imidazole binding sites [2]. rilmenidine, a new antihypertensive agent, appeared 2.5 and 3.5 times more selective than clonidine and guanfacine, respectively, for medullary ipr sites than for cortical α-adrenoceptors [3]. rilmenidine targeted the nonadrenergic imidazoline-binding site i1 receptor with the ki value of 7.1 nm and demonstrated weaker affinity for the i2 receptor with the ki value of 5.2 μm [4].

in vivo

in rat model of hypertension associated with insulin resistance, rilmenidine ameliorated the deleterious effects of a high-fructose diet, such as weight gain, hypertension, and resistance to the effects of insulin [5]. in a mouse model of huntington's disease, rilmenidine induced autophagy, attenuated toxicity of polyglutamine expansions and the signs of disease, reduced the mutant huntingtin fragment levels [6].

storage

Store at -20°C

References

[1] reis, d. j. and piletz, j.e. the imidazoline receptor in control of blood pressure by clonidine and allied drugs. american journal of physiology 273(5 pt 2), r1569-r1571 (1997).
[2] gomez r e, ernsberger p, feinland g, et al. rilmenidine lowers arterial pressure via imidazole receptors in brainstem c1 area[j]. european journal of pharmacology, 1991, 195(2): 181-191.
[3] bricca g, dontenwill m, molines a, et al. rilmenidine selectivity for imidazoline receptors in human brain[j]. european journal of pharmacology, 1989, 163(2): 373-377.
[4] guyenet p g. is the hypotensive effect of clonidine and related drugs due to imidazoline binding sites [j]. american journal of physiology-regulatory, integrative and comparative physiology, 1997, 273(5): r1580-r1584.
[5] penicaud l, berthault m f, morin j, et al. rilmenidine normalizes fructose-induced insulin resistance and hypertension in rats[j]. journal of hypertension. supplement: official journal of the international society of hypertension, 1998, 16(3): s45-9.
[6] rose c, menzies f m, renna m, et al. rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of huntington's disease[j]. human molecular genetics, 2010, 19(11): 2144-2153.

RILMENIDINE HEMIFUMARATE SALT Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

RILMENIDINE HEMIFUMARATE SALT Suppliers

China 18 India 1 Switzerland 1 United Kingdom 1 United States 6 USA 1 Global 28

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 4006
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd

Tel: 024-024-88590548 18341751992
Email: 757984502@qq.com
Country: China
ProdList: 891
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: +86-18521732826
Email: market@aladdin-e.com
Country: China
ProdList: 48461
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd.

Tel: 025-66061636 18013972705
Email: qqyang@aikonchem.com
Country: China
ProdList: 10238
Advantage: 58

Guangdong Wengjiang Chemical Reagent Co.,Ltd.

Tel: 0751-2815983 13927872582
Fax: 0751-2886750
Email: 3008325437@qq.com
Country: China
ProdList: 3876
Advantage: 58

Tel: 58896805
Email: 7993601name@qq.com
Country: CHINA
ProdList: 15620
Advantage: 58

Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd

Tel: +86-18341751992 +86-15382112998
Email: 757984502@qq.com
Country: China
ProdList: 892
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Guangzhou WeiBo Chemical Co., Ltd.

Tel: --
Fax: --
Email: weibochem@163.com
Country: China
ProdList: 6187
Advantage: 67

207572-68-7, RILMENIDINE HEMIFUMARATE SALTRelated Search:

Rilmenidine

RILMENIDINE HEMIFUMARATE SALT

n-(dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine hemifumarate salt

Oxaminozoline hemifumarate salt, Rilmenidene hemifumarate salt, N-(Dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine hemifumarate salt

LZFATBMLSYHRTC-WXXKFALUSA-N

207572-68-7

C24H36N4O6

C10H16N2O12C4H4O4