ATC 0175

Product Name: ATC 0175
CAS No.: 510733-97-8
Chemical Name: ATC 0175
Synonyms: ATC 0175 HCl;ATC 0175 hydrochloride;N-[cis-4-[[4-(Dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluorobenzamidehydrochloride;Rel-N-((1s,4s)-4-((4-(dimethylamino)quinazolin-2-yl)amino)cyclohexyl)-3,4-difluorobenzamide hydrochloride
CBNumber: CB5972935
Molecular Formula: C23H25F2N5O.ClH
Formula Weight: 461.941
MOL File: 510733-97-8.mol

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ATC 0175 Property

storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL
form: solid
color: White to light yellow

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A3355
Product name: ATC0175
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $436
Updated: 2025/07/31

Tocris

Product number: 3346
Product name: ATC0175hydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $220
Updated: 2021/12/16

Tocris

Product number: 3346
Product name: ATC0175hydrochloride
Purity: ≥98%(HPLC)
Packaging: 50
Price: $897
Updated: 2021/12/16

TRC

Product number: A790540
Product name: ATC0175
Packaging: 10mg
Price: $265
Updated: 2021/12/16

Usbiological

Product number: 254689
Product name: ATC 0175 hydrochloride
Packaging: 10mg
Price: $489
Updated: 2021/12/16

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ATC 0175 Chemical Properties,Usage,Production

Uses

ATC0175 is a MCHR1, SR-1A and SR-2B inhibitor.

Biological Activity

Potent, selective and orally active melanin-concentrating hormone receptor 1 (MCH 1 ) antagonist (IC 50 values are 13.5 and > 10000 nM for MCH1 and MCH2 receptors respectively). Exhibits anxiolytic and antidepressant activity in rodents. Also displays affinity for 5-HT 2B and 5-HT 1A receptors (IC 50 values are 9.66 and 16.9 nM respectively).

in vitro

assays showed that this compound is a potent antagonist with a high affinity for mch1r. the receptor binding and the functional assay (mch-induced increase in [ca2+]) indicated that atc0175 is a noncompetitive antagonist at mch1rs 1.

in vivo

atc0175 displayed anxiolytic effects in numerous animal models of anxiety including the social interaction test, elevated plus-maze test, maternal separation-induced vocalization and stress-induced hyperthermia. in addition, atc0175 treatment also exhibited antidepressant effects in the forced swimming test 2.

References

1. semple g, tran ta, kramer b, et al. pyrimidine-based antagonists of h-mch-r1 derived from atc0175: in vitro profiling and in vivo evaluation. bioorganic & medicinal chemistry letters. 2009;19(21):6166-6171.2. chaki s, yamaguchi j, yamada h, et al. atc0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. cns drug reviews. 2005;11(4):341-352.

ATC 0175 Preparation Products And Raw materials

Raw materials

Preparation Products

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ATC 0175 Suppliers

China 28 Switzerland 1 United Kingdom 1 United States 6 USA 1 Global 37

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 42446
Advantage: 60

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9119
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 1010
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

510733-97-8, ATC 0175Related Search:

ATC 0175 hydrochloride

N-[cis-4-[[4-(Dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluorobenzamidehydrochloride

ATC 0175 HCl

Rel-N-((1s,4s)-4-((4-(dimethylamino)quinazolin-2-yl)amino)cyclohexyl)-3,4-difluorobenzamide hydrochloride

510733-97-8

C23H26ClF2N5O

C23H25F2N5OHCl