N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE

Product Name: N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE
CAS No.: 42137-88-2
Chemical Name: N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE
Synonyms: DK780;NSC 49364;LABOTEST-BB LT00455209;N,N-Bis(2-chloroethyl);N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE;N,N-Bis(-chloroethyl)-p-toluenesulfonamide;N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE;N,N-BIS(B-CHLOROETHYL)-P-TOLUENESULFONAMIDE;N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULPHONAMIDE;N-N-BIS(BETA-CHLOROETHYL)-P-TOLUENESULFONAMIDE
CBNumber: CB6102126
Molecular Formula: C11H15Cl2NO2S
Formula Weight: 296.21
MOL File: 42137-88-2.mol

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N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE Property

Melting point:: 43-50 °C
Boiling point:: 409.1±55.0 °C(Predicted)
Density: 1.2228 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Chloroform
form: powder to crystal
pka: -8.48±0.70(Predicted)
color: White to Light yellow
BRN: 2134258
InChIKey: PTVBBIMKLOMGSY-UHFFFAOYSA-N
CAS DataBase Reference: 42137-88-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25
HS Code: 29350090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S358630
Product name: N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $30.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: S358630
Product name: N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE
Purity: AldrichCPR
Packaging: 250MG
Price: $29.8
Updated: 2024/03/01

TCI Chemical

Product number: B4059
Product name: N,N-Bis(2-chloroethyl)-p-toluenesulfonamide
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $77
Updated: 2025/07/31

TCI Chemical

Product number: B4059
Product name: N,N-Bis(2-chloroethyl)-p-toluenesulfonamide
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $270
Updated: 2025/07/31

TRC

Product number: B419010
Product name: N,N-Bis(2-chloroethyl)-p-toluenesulfonamide,TechnicalGrade90%
Packaging: 1g
Price: $50
Updated: 2021/12/16

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N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE Chemical Properties,Usage,Production

Chemical Properties

GREY TO GREY-BROWN POWDER

Uses

N,N-Bis(2-chloroethyl)-p-toluenesulfonaMide can be used as an intermediate used in the process for preparation of Cetirizine (C281100).

Synthesis

821-48-7

98-59-9

42137-88-2

Bis(2-chloroethyl)amine hydrochloride (25.2 g, Tokyo Chemical Industry CO., LTD.) was suspended in dichloromethane (280 mL) and the suspension was cooled to 0 °C. Pyridine (24 mL) and p-toluenesulfonyl chloride (28.3 g) were added sequentially under stirring, followed by stirring the reaction mixture for 4 hours at room temperature. Upon completion of the reaction, saturated aqueous sodium bicarbonate solution was added to the mixture for neutralization, and then the organic phase was extracted with dichloromethane. The organic layer was washed sequentially with 1N aqueous hydrochloric acid and deionized water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product obtained was purified by silica gel column chromatography with the eluent being hexane-ethyl acetate in different ratios (15:1 to 5:1) to afford N,N-bis(2-chloroethyl)-4-methylbenzenesulfonamide (30.0 g, 71% yield). The structure of the product was confirmed by 1H-NMR (300 MHz, DMSO-d6): δ 2.41 (3H, s, CH3), 3.45 (4H, t, J = 6.9 Hz, CH2Cl), 3.72 (4H, t, J = 6.9 Hz, CH2N), 7.44 (2H, d, J = 8.2 Hz, ArH), 7.75 (2H, d, J = 8.2 Hz, ArH).

References

[1] Journal of Molecular Structure, 2009, vol. 923, # 1-3, p. 132 - 140
[2] Patent: EP1714961, 2006, A1. Location in patent: Page/Page column 18
[3] Patent: WO2013/175499, 2013, A2. Location in patent: Page/Page column 23
[4] Patent: US2014/179713, 2014, A1. Location in patent: Paragraph 0085
[5] RSC Advances, 2015, vol. 5, # 118, p. 97205 - 97211

N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE Preparation Products And Raw materials

Raw materials

Diethanolamine Tosyl chloride Thionyl chloride

Preparation Products

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N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE Suppliers

Americas 1 Belgium 2 Canada 2 China 100 Europe 1 France 2 Germany 6 India 24 Japan 2 Switzerland 1 United Kingdom 10 United States 32 Global 183

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
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Alfa Aesar

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Ark Pharm, Inc.

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Shanghai Sphchem Co., Ltd.

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BioBioPha Co., Ltd.

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Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.

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Thermo Fisher Scientific

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View Lastest Price from N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE manufacturers

Career Henan Chemical Co

Product: N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE 42137-88-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-25

42137-88-2, N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDERelated Search:

Bisbiphenyl-4-yl-(4'-broMo-biphenyl-4-yl)-aMine N,N-Dimethyl methanesulfonamide p-Toluenesulfonamide p-Toluenesulfonic acid Sulfamide N,N-DIMETHYL-P-TOLUENESULFONAMIDE Ethyl-p-toluenesulfonamide -EthylbenzenesulfonaMide N,N-Diethyl-4-methylbenzenesulfonamide N-Methyl-p-toluenesulfonamide N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE Nornitrogen mustard 4-[BIS-(2-CHLORO-ETHYL)-SULFAMOYL]-BENZOIC ACID N1,N1-DI(2-CHLOROALLYL)-4-METHYLBENZENE-1-SULFONAMIDE AKOS 360

LABOTEST-BB LT00455209

N-N-BIS(BETA-CHLOROETHYL)-P-TOLUENESULFONAMIDE

N,N-BIS(B-CHLOROETHYL)-P-TOLUENESULFONAMIDE

N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE

N,N-BIS(2-CHLOROETHYL)-P-TOLUENESULPHONAMIDE

N,N-BIS(2-CHLOROETHYL)-4-METHYLBENZENESULFONAMIDE

Benzenesulfonamide, N,N-bis(2-chloroethyl)-4-methyl-

N,N-Bis(-chloroethyl)-p-toluenesulfonamide

N,N-Bis-(2-chloroethyl)-p-toluenesulfonamide, tech., 90%

N,N-Bis-(2-chloroethyl)-p-toluenesulfonamide,90%,tech.

N,N-Bis(2-chloroethyl)-4-methylbenzensulfonamide

N,N-Bis(2-chloroethyl)-p-toluenesulfonaMide, Technical Grade 90%

NSC 49364

N,N-Bis(2-chloroethyl)-p-toluenesulfonaMide,TechnicalGrade90%

N,N-Bis(2-chloroethyl)

N-BIS(2-CHLOROETHYL)-P-TOLUENESULFONAMIDE

N,N-Bis(2-chloroethyl)-p-toluenesulfonamide &gt

DK780

N,N-Bis-2-chloroethyl p-toluenesulfonic acid ammonium

42137-88-2

4237-88-2

C11H15Cl12NO2S

C11H15Cl2NO2S

Amines

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds

Phenyls & Phenyl-Het