(-)-Bicucullinemethiodide
- Product Name
- (-)-Bicucullinemethiodide
- CAS No.
- 40709-69-1
- Chemical Name
- (-)-Bicucullinemethiodide
- Synonyms
- (-)-Bicuculline methiodide;(+)-Bicuculline methiodide;( ) Bicuculline methiodide,()Bicuculline methiodide;(-)-Bicuculline methiodide DISCONTINUED. offer B382505;(5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide;[R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide;1,3-Dioxolo(4,5-G)isoquinolinium, 5-((6R)-6,8-dihydro-8-oxofuro(3,4-E)-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-, iodide, (5S)-;1,3-Dioxolo(4,5-G)isoquinolinium, 5-(6,8-dihydro-8-oxofuro(3,4-E)-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-, iodide, (R-(R*,S*))-;(5S)-6,6-Dimethyl-5-{12-oxo-3,5,11-trioxatricyclo[7.3.0.02,]dodeca-1(9),2(6),7-trien-10-yl}-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium iodide
- CBNumber
- CB61075225
- Molecular Formula
- C21H20INO6
- Formula Weight
- 0
- MOL File
- 40709-69-1.mol
(-)-Bicucullinemethiodide Property
- RTECS
- JI4904100
- storage temp.
- Store at RT
- solubility
- H2O: soluble10mg/mL, almost clear, greenish-yellow
- form
- Pale yellow solid.
- color
- Yellow
- optical activity
- [α]/D -117±7°, c = 1 in chloroform
- BRN
- 5419649
Safety
- WGK Germany
- 3
- HazardClass
- 6.1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H311Toxic in contact with skin
H330Fatal if inhaled
H400Very toxic to aquatic life
- Precautionary statements
-
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P320Specific treatment is urgent (see … on this label).
P330Rinse mouth.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 14343
- Product name
- 1(S),9(R)-(?)-Bicuculline methiodide
- Purity
- ≥95.0% (HPCE)
- Packaging
- 10mg
- Price
- $71.5
- Updated
- 2024/03/01
- Product number
- 14343
- Product name
- 1(S),9(R)-(?)-Bicuculline methiodide
- Purity
- ≥95.0% (HPCE)
- Packaging
- 50mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- J67150
- Product name
- (-)-Bicuculline methiodide, 98%
- Packaging
- 50mg
- Price
- $243.65
- Updated
- 2024/03/01
- Product number
- 2503
- Product name
- (-)-Bicucullinemethiodide
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $93
- Updated
- 2021/12/16
- Product number
- 2503
- Product name
- (-)-Bicucullinemethiodide
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $395
- Updated
- 2021/12/16
(-)-Bicucullinemethiodide Chemical Properties,Usage,Production
Uses
1(S),9(R)-(-)-Bicuculline methiodide has been used as a gamma-aminobutyric acid (GABA) antagonist to block inhibition in the semicoronal slices. It has also been used for the preparation of organotypic hippocampal slice cultures (OHSCs).
General Description
Bicuculline is a phthalide isoquinoline alkaloid, which is extracted from Dicentra cucullaria. It acts as an acetylcholinesterase?inhibitor. Bicuculline inhibits slow afterhyperpolarization (AHP).
Biological Activity
Methiodide form of classical GABA A receptor antagonist (+)-bicuculline ([R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one ). More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels.
Biochem/physiol Actions
(-)-Bicuculline methiodide is a GABAA receptor antagonist, which acts as a competitive inhibitor of GABA ligand binding to the receptor.
storage
Room temperature