ChemicalBook > CAS DataBase List > Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)-

Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)-

Product Name
Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)-
CAS No.
2377352-49-1
Chemical Name
Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)-
Synonyms
SHP-1971;GDC-1971;Migoprotafib;GDC-1971 (RLY-1971);Migoprotafib (GDC-1971);(R)-1'-(3-(3,4-Dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-3H-spiro[benzofuran-2,4'-piperidin]-3-amine;(R)-1'-(3-(3,4-Dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-3H-spiro[benzofuran-2,4'-piperidin]-3-amine;Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)-
CBNumber
CB610860058
Molecular Formula
C25H26N8O
Formula Weight
454.54
MOL File
2377352-49-1.mol
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Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)- Property

Boiling point:
714.1±60.0 °C(Predicted)
Density 
1.48±0.1 g/cm3(Predicted)
solubility 
Acetonitrile: Slightly soluble: 0.1-1 mg/ml
Methanol: Sparingly soluble: 1-10 mg/ml
form 
Solid
pka
9.52±0.50(Predicted)
color 
Light yellow to yellow
InChIKey
RGCGBFIARQENML-ZEGQKUPANA-N
SMILES
N[C@@H]1C2=CC=CC=C2OC21CCN(C1=CN=C3C(N4CCCC5=NC=CC=C45)=NNC3=N1)CC2 |&1:1,r|
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Hazard and Precautionary Statements (GHS)

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Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)- Chemical Properties,Usage,Production

Description

Migoprotafib is a protein tyrosine phosphate, also known as HPTP, inhibitor with potential as an antineoplastic agent.

Uses

Migoprotafib (GDC-1971) (compound 199) is a SHP2 inhibitor. Migoprotafib inhibits the MAPK/ERK signaling pathway, and exhibits antitumor activity[1][2].

in vivo

Migoprotafib (60 mg/kg, po for 28 days) exhibits antitumor efficacy in RIT1 xenograft mouse models[2].

Animal Model:RIT1 xenograft mouse models[2]
Dosage:60 mg/kg
Administration:po for 28 days
Result:Inhibited tumor growth.

References

[1] Alexander M, et al. Shp2 phosphatase inhibitors and methods of use thereof. Patent WO2019183367A1.
[2] Maddalo D, et al. RIT1M90I is a driver of lung adenocarcinoma tumorigenesis and resistance to targeted therapy[J]. 2024.
[3] ALEXANDER M. TAYLOR*, LINDSAY WILLMORE   Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors[J]. Journal of Medicinal Chemistry, 2023, 66 19: 13384-13399. DOI: 10.1021/acs.jmedchem.3c00483

Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)- Preparation Products And Raw materials

Raw materials

Preparation Products

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Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)- Suppliers

China 35 United States 1 Global 36
Beijing Concision Pharmaceutical Tech. Co.,Ltd
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2377352-49-1, Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)-Related Search:


  • Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)-
  • GDC-1971
  • SHP-1971
  • GDC-1971 (RLY-1971)
  • Migoprotafib (GDC-1971)
  • Migoprotafib
  • (R)-1'-(3-(3,4-Dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-3H-spiro[benzofuran-2,4'-piperidin]-3-amine
  • (R)-1'-(3-(3,4-Dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-3H-spiro[benzofuran-2,4'-piperidin]-3-amine
  • 2377352-49-1