2(1H)-Pyridinone, 3-(aminomethyl)-4,6-dimethyl- (9CI)
- Product Name
- 2(1H)-Pyridinone, 3-(aminomethyl)-4,6-dimethyl- (9CI)
- CAS No.
- 771579-27-2
- Chemical Name
- 2(1H)-Pyridinone, 3-(aminomethyl)-4,6-dimethyl- (9CI)
- Synonyms
- 3-(AMinoMethyl)-4,6-diMethyl-1,2-dihydropyridin-2-one;N-BUTYL-2-CHLOROISONICOTINAMIDE;3-(aminomethyl)-4,6-dimethyl-1H-pyridin-2-one;3-(Aminomethyl)-4,6-dimethyl-2(1H)-pyridinone;2(1H)-Pyridinone,3-(aMinoMethyl)-4,6-diMethyl-;2(1H)-Pyridinone, 3-(aminomethyl)-4,6-dimethyl- (9CI);3-(AMinoMethyl)-4,6-diMethyl-1,2-dihydropyridine-2-one;3-(Aminomethyl)-4,6-Dimethylpyridin-2(1H)-One(WX603161);(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methylazanium chloride;2(1H)-Pyridinone,3-(aMinoMethyl)-4,6-diMethyl-,hydrochloride(1:1)
- CBNumber
- CB61087808
- Molecular Formula
- C8H12N2O
- Formula Weight
- 152.19
- MOL File
- 771579-27-2.mol
2(1H)-Pyridinone, 3-(aminomethyl)-4,6-dimethyl- (9CI) Property
- Boiling point:
- 348.1±34.0 °C(Predicted)
- Density
- 1.054±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 12.40±0.10(Predicted)
- Appearance
- White to yellow Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A615960
- Product name
- 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one
- Packaging
- 50mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-0008592
- Product name
- 3-(Aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one
- Purity
- 99.37%
- Packaging
- 5g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-0008592
- Product name
- 3-(Aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one
- Purity
- 99.37%
- Packaging
- 10g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- OR921633
- Product name
- 3-(Aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one
- Purity
- 97%
- Packaging
- 5g
- Price
- $112
- Updated
- 2021/12/16
- Product number
- 2037AC
- Product name
- 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one
- Packaging
- 5g
- Price
- $165
- Updated
- 2021/12/16
2(1H)-Pyridinone, 3-(aminomethyl)-4,6-dimethyl- (9CI) Chemical Properties,Usage,Production
Uses
3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one is a reactant in the preparation of pyrazolopyridine and indazoles as histone lysine methyltransferase EZH2 inhibitors.
Synthesis
769-28-8
771579-27-2
General procedure for the synthesis of 3-(aminomethyl)-4,6-dimethylpyridin-2(1H)-one from 2-oxo-4,6-dimethyl-1,2-dihydropyridine-3-carbonitrile: Carbon-loaded palladium (10%, 324 mg) and platinum oxide (21.8 mg) were added to 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (3 g, 20.3 mmol) to a mixture of sodium acetate (3.1 g, 37.5 mmol) and acetic acid (100 mL). The reaction mixture was stirred under hydrogen atmosphere for 48 hours. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated to dryness. The residue was treated with concentrated hydrochloric acid (3 mL) and ethanol (15 mL), cooled to 0°C and stirred at that temperature for 2 hours to form a suspension. The precipitate was collected by filtration, washed sequentially with cold ethanol and ether, and dried under vacuum to give a white solid product (3.5 g, 92% yield) with a melting point of 253-258 °C. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) and 13C NMR (100 MHz, DMSO-d6), and analyzed by high-resolution mass spectrometry (HRMS-ESI), and the results were in agreement with expectations.
References
[1] Synthetic Communications, 2016, vol. 46, # 14, p. 1215 - 1222
[2] Patent: WO2013/75083, 2013, A1. Location in patent: Paragraph 00177; 00178
[3] Patent: US9206128, 2015, B2. Location in patent: Page/Page column 103; 104
[4] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 12, p. 1091 - 1096
[5] Journal of Medicinal Chemistry, 2016, vol. 59, # 16, p. 7617 - 7633
2(1H)-Pyridinone, 3-(aminomethyl)-4,6-dimethyl- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
2(1H)-Pyridinone, 3-(aminomethyl)-4,6-dimethyl- (9CI) Suppliers
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16077
- Advantage
- 64
- Tel
- 028-81458053
- Fax
- 028-81458053
- novibiotech@163.com sales@novi-biotech.com
- Country
- China
- ProdList
- 226
- Advantage
- 55
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 15928766785 15928766785
- Fax
- QQ961458712
- wupengcheng@astatech.cn
- Country
- China
- ProdList
- 1987
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 0519-0519-83812535
- Fax
- 86-0519-88012122
- sales@qinuochem.com
- Country
- China
- ProdList
- 287
- Advantage
- 60
- Tel
- 028-028-60651388 13330964498
- slyu@hengkangtech.com
- Country
- China
- ProdList
- 378
- Advantage
- 58
- Tel
- 13817873692
- Fax
- 021-31329586
- mkt@boynerspharm.com
- Country
- China
- ProdList
- 1707
- Advantage
- 55
- Tel
- 28-87999436 02887999436
- Fax
- QQ:2746983436
- sales@sano-chem.com
- Country
- China
- ProdList
- 3795
- Advantage
- 55
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9248
- Advantage
- 55
View Lastest Price from 2(1H)-Pyridinone, 3-(aminomethyl)-4,6-dimethyl- (9CI) manufacturers
- Product
- 2(1H)-Pyridinone, 3-(aminomethyl)-4,6-dimethyl- (9CI) 771579-27-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25
- Product
- 2(1H)-Pyridinone, 3-(aminomethyl)-4,6-dimethyl- (9CI) 771579-27-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-09