1-Cyclopropyl-1,3-butanedione
- Product Name
- 1-Cyclopropyl-1,3-butanedione
- CAS No.
- 21573-10-4
- Chemical Name
- 1-Cyclopropyl-1,3-butanedione
- Synonyms
- 3-butanedione;1-Cyclopropyl-1;Cyclopropionylacetone;ACETOACETYL CYCLOPROPANE;1-Cyclopropyl-1,3-butandione;1-CYCLOPROPYL-1,3-BUTANEDIONE;1-Cyclopropylbutane-1,3-dione;1,3-Butanedione, 1-cyclopropyl-;1-cyclopropyl-1,3-butanedione(SALTDATA: FREE)
- CBNumber
- CB61092336
- Molecular Formula
- C7H10O2
- Formula Weight
- 126.15
- MOL File
- 21573-10-4.mol
1-Cyclopropyl-1,3-butanedione Property
- Boiling point:
- 68-70 °C(Press: 12 Torr)
- Density
- 1.100±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform, Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Oil
- pka
- 9.63±0.20(Predicted)
- color
- Clear Colorless
- InChIKey
- KLCGMDWRXACELA-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SYX00054
- Product name
- 1-Cyclopropyl-1,3-butanedione
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $308
- Updated
- 2023/01/07
- Product number
- C989675
- Product name
- 1-Cyclopropyl-1,3-butanedione
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C989675
- Product name
- 1-Cyclopropyl-1,3-butanedione
- Packaging
- 5g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 065612
- Product name
- 1-Cyclopropylbutane-1,3-dione
- Packaging
- 5g
- Price
- $37
- Updated
- 2021/12/16
- Product number
- 2218-1-15
- Product name
- 1-Cyclopropyl-1,3-butanedione
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
1-Cyclopropyl-1,3-butanedione Chemical Properties,Usage,Production
Uses
1-Cyclopropyl-1,3-butanedione is a reagent in regioselective synthesis of pyrazolylpyrazolopyrimidine derivatives in aqueous medium for antimicrobial agents.
Synthesis
765-43-5
141-78-6
21573-10-4
1. Sodium hydride (60% dispersion in oil, 0.95 g, 23.8 mmol) was washed several times with pentane and then suspended in 18 ml of anhydrous tetrahydrofuran under nitrogen protection. 2. To the above suspension was added ethyl acetate (2.3 ml, 23.5 mmol) and 2 drops of ethanol. 3. A solution of cyclopropylmethyl ketone (1.0 g, 11.9 mmol) dissolved in 5 ml of anhydrous tetrahydrofuran was added dropwise with stirring while the reaction temperature was controlled below 20 °C using an ice bath. 4. After addition of 18-crown-6 (63 mg, 0.25 mmol), the reaction mixture was stirred at 40 °C for 4 hours. 5. After completion of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was partitioned between ether and water. 6. The aqueous phase was separated and washed with ether. 7. The aqueous solution was acidified to pH 2 with 2N hydrochloric acid. 8. The acidified aqueous solution was extracted three times with ether and the organic phases were combined. 9. The organic phase was washed with brine, dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to give cyclopropyl-1,3-butanedione (0.7 g, 5.5 mmol, 47% yield). 10. The product was analyzed to show 100% purity and the structure was confirmed by 1H NMR and UPLC/MS.
References
[1] Journal of Labelled Compounds and Radiopharmaceuticals, 2009, vol. 52, # 10, p. 435 - 442
[2] Patent: CN108840791, 2018, A. Location in patent: Paragraph 0030-0031; 0033-0038; 0040-0044; 0046-0050; 0052
[3] Patent: WO2013/10880, 2013, A1. Location in patent: Page/Page column 166-167
[4] Journal of Organic Chemistry, 1952, vol. 17, p. 685,688
[5] Patent: EP2548863, 2013, A1. Location in patent: Paragraph 0179
1-Cyclopropyl-1,3-butanedione Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Cyclopropyl-1,3-butanedione manufacturers
- Product
- 1-Cyclopropyl-1,3-butanedione 21573-10-4
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-27
- Product
- 1-Cyclopropyl-1,3-butanedione 21573-10-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 1-Cyclopropyl-1,3-butanedione 21573-10-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09