Apoptolidin

Product Name: Apoptolidin
CAS No.: 194874-06-1
Chemical Name: Apoptolidin
Synonyms: FU 40A;Apoptolidin;Apoptolidin A Ready Made Solution;L-glycero-α-D-galacto-2-Nonulopyranose, O-2,6-dideoxy-3-O-methyl-β-D-arabino-hexopyranosyl-(1→4)-O-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→8)-3,5,7-trideoxy-1-C-[(2S,4S,5S,8E,10E,12R,13R,14E,16E,18E)-12-[(6-deoxy-4-O-methyl-α-L-glucopyranosyl)oxy]-5-hydroxy-4-methoxy-9,13,15,17,19-pentam...
CBNumber: CB61093252
Molecular Formula: C58H96O21
Formula Weight: 1129.38
MOL File: 194874-06-1.mol

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Apoptolidin Property

Melting point:: 128-130°
alpha: 21D -5.2° (c = 1.0 in methanol)
Boiling point:: 1108.9±65.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
Flash point:: 87℃
storage temp.: -20°C
solubility: Soluble in DMSO, DMF, ethanol, or methanol.
pka: 11.71±0.70(Predicted)
form: DMSO solution
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, ethanol or methanol may be stored at -20°C for up to 3 months.

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Safety

RIDADR: NA 1993 / PGIII
WGK Germany: 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0907
Product name: Apoptolidin A Ready Made Solution
Purity: 1?mg/mL in DMSO
Packaging: 500μl
Price: $971
Updated: 2024/03/01

Cayman Chemical

Product number: 19435
Product name: Apoptolidin
Purity: ≥95%
Packaging: 100μg
Price: $263
Updated: 2024/03/01

Cayman Chemical

Product number: 19435
Product name: Apoptolidin
Purity: ≥95%
Packaging: 500μg
Price: $1043
Updated: 2024/03/01

TRC

Product number: A729048
Product name: Apoptolidin
Packaging: 250μg
Price: $430
Updated: 2021/12/16

TRC

Product number: A729048
Product name: Apoptolidin
Packaging: 100μg
Price: $215
Updated: 2021/12/16

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Apoptolidin Chemical Properties,Usage,Production

Description

Apoptolidin (194874-06-1) is a powerful inducer of apoptosis in a variety of cancer cell lines.1?Is believed to act via inhibition of F0F1-ATPase2?but correlation studies indicate that a second mechanism may be the actual mode of action3.? Cell permeable.

Uses

Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene (IC50 = 11 ng/ml). Apoptolidin is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines. Although the apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition, recent evidence suggests the existence of a secondary biological target or more complex mode of action.

References

1) Kim et al. (1997), Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp.; J. Antibiot. (Tokyo), 50 628 2) Salomon et al. (2001), Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase; Chem. Biol., 8 71 3) Wender et al. (2006), Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues; Org. Lett., 8 589

Apoptolidin Preparation Products And Raw materials

Raw materials

Preparation Products

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Apoptolidin Suppliers

China 16 India 1 United Kingdom 1 United States 8 Global 26

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57423
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

BOC Sciences

Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Country: United States
ProdList: 19741
Advantage: 58

Meng Cheng Technology (Shanghai) Co., LTD

Tel: 400-820-6829
Email: sales@mitachieve.com
Country: China
ProdList: 8860
Advantage: 58

Zhejiang Huida Biotech Co., LTD

Tel: 0571-89903882 13626641628
Email: jiangnan@huidabiotech.com
Country: China
ProdList: 3656
Advantage: 58

194874-06-1, ApoptolidinRelated Search:

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Apoptolidin

Apoptolidin A Ready Made Solution

FU 40A

L-glycero-α-D-galacto-2-Nonulopyranose, O-2,6-dideoxy-3-O-methyl-β-D-arabino-hexopyranosyl-(1→4)-O-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→8)-3,5,7-trideoxy-1-C-[(2S,4S,5S,8E,10E,12R,13R,14E,16E,18E)-12-[(6-deoxy-4-O-methyl-α-L-glucopyranosyl)oxy]-5-hydroxy-4-methoxy-9,13,15,17,19-pentam...

194874-06-1

C58H96O21