5-Thiazolecarboxylic acid, 4-amino-, methyl ester
- Product Name
- 5-Thiazolecarboxylic acid, 4-amino-, methyl ester
- CAS No.
- 278183-10-1
- Chemical Name
- 5-Thiazolecarboxylic acid, 4-amino-, methyl ester
- Synonyms
- Methyl 4-aminothiazole-5-carboxylate;4-aMino-, Methyl ester;Methyl 4-amino-5-thiazole;Methyl 4-amino-5-thiazolecarboxylate;4-Amino-5-(methoxycarbonyl)-1,3-thiazole;Methyl 4-amino-5-thiazolecarboxylateamino;Methyl 4-amino-1,3-thiazole-5-carboxylate;4-Amino-thiazole-5-carboxylicacidmethylester;5-Thiazolecarboxylicacid,4-D1034-,methylester;4-Amino-5-thiazolecarboxylic acid methyl ester
- CBNumber
- CB61094158
- Molecular Formula
- C5H6N2O2S
- Formula Weight
- 158.18
- MOL File
- 278183-10-1.mol
5-Thiazolecarboxylic acid, 4-amino-, methyl ester Property
- Boiling point:
- 291℃
- Density
- 1.408
- Flash point:
- 130℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.29±0.10(Predicted)
- form
- powder
- color
- Brown
Safety
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M332295
- Product name
- Methyl4-Aminothiazole-5-carboxylate
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- J96776
- Product name
- Methyl4-amino-5-thiazolecarboxylate
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR301121
- Product name
- Methyl4-amino-1,3-thiazole-5-carboxylate
- Packaging
- 250mg
- Price
- $69
- Updated
- 2021/12/16
- Product number
- 8H58-1-01
- Product name
- Methyl 4-amino-5-thiazolecarboxylateamino
- Packaging
- 250mg
- Price
- $76
- Updated
- 2021/12/16
- Product number
- 8H58-1-01
- Product name
- Methyl 4-amino-5-thiazolecarboxylateamino
- Packaging
- 1g
- Price
- $186
- Updated
- 2021/12/16
5-Thiazolecarboxylic acid, 4-amino-, methyl ester Chemical Properties,Usage,Production
Uses
Methyl 4-Aminothiazole-5-carboxylate is used in preparation of Carboxamides as enzyme inhibitors.
Synthesis
60093-05-2
278183-10-1
General procedure for the synthesis of methyl 4-amino-5-thiazolecarboxylate from methyl 4-amino-2-(methylthio)thiazole-5-carboxylate: methyl 4-amino-2-(methylthio)-1,3-thiazole-5-carboxylate (6.74 g, 33 mmol) was mixed with Raney-Nickel (commercially available slurry, ~15 mL, added in 5 portions) in ethanol (200 mL) in a The suspension was hydrogenated and reacted at 45 psi hydrogen pressure for 1 week. Upon completion of the reaction, the catalyst was removed by filtration and washed with ethyl acetate and ethanol. The filtrate was evaporated to give the crude product. Purification of the crude product by fast column chromatography [eluent: ethyl acetate/isohexane (1:4)] afforded methyl 4-amino-5-thiazolecarboxylate as a bright yellow solid (1.23 g, 24% yield). The product was characterized by NMR (400 MHz, CDCl3): δ 8.54 (1H, s), 5.90 (2H, brs), 3.84 (3H, s). The mass spectrum (ES+) showed a m/z of 159 ([M+H]+).
References
[1] Patent: WO2005/49613, 2005, A1. Location in patent: Page/Page column 42
5-Thiazolecarboxylic acid, 4-amino-, methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Thiazolecarboxylic acid, 4-amino-, methyl ester manufacturers
- Product
- 5-Thiazolecarboxylic acid, 4-amino-, methyl ester 278183-10-1
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 200kg
- Release date
- 2020-03-06