tert-Butyl 2-(aminomethyl)phenylcarbamate
- Product Name
- tert-Butyl 2-(aminomethyl)phenylcarbamate
- CAS No.
- 849020-94-6
- Chemical Name
- tert-Butyl 2-(aminomethyl)phenylcarbamate
- Synonyms
- 2-(Boc-amino)benzylamine;2-(Aminomethyl)-N-Boc-aniline;2-(tert-Butoxycarbonylamino)benzylamine;2-(Aminomethyl)aniline, 1-BOC protected;TERT-BUTYL 2-(AMINOMETHYL)PHENYLCARBAMATE;ert-Butyl N-(2-aminomethylphenyl)carbamate;2-(Aminomethyl)aniline, 1-BOC protected 95+%;tert-Butyl N-[2-(aminomethyl)phenyl]carbamate;2-(Aminomethyl)-N-(tert-butoxycarbonyl)aniline;tert-Butyl 2-(aminomethyl)phenylcarbamate ISO 9001：2015 REACH
- CBNumber
- CB61096637
- Molecular Formula
- C12H18N2O2
- Formula Weight
- 222.28
- MOL File
- 849020-94-6.mol
tert-Butyl 2-(aminomethyl)phenylcarbamate Property
- Boiling point:
- 238-242℃
- Density
- 1.054g/mLat 25℃
- Flash point:
- 71°C
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- liquid
- pka
- 13.67±0.70(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 709700
- Product name
- 2-(Boc-amino)benzylamine
- Packaging
- 1g
- Price
- $115.9
- Updated
- 2025/07/31
- Product number
- T206103
- Product name
- tert-Butyl2-(Aminomethyl)phenylcarbamate
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- CS-W005861
- Product name
- tert-Butyl(2-(aminomethyl)phenyl)carbamate
- Packaging
- 1g
- Price
- $71
- Updated
- 2021/12/16
- Product number
- FB50901
- Product name
- tert-Butyl 2-(aminomethyl)phenylcarbamate
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 009283
- Product name
- tert-Butyl 2-(aminomethyl)phenylcarbamate
- Packaging
- 1g
- Price
- $98
- Updated
- 2021/12/16
tert-Butyl 2-(aminomethyl)phenylcarbamate Chemical Properties,Usage,Production
Uses
Reactant for:
- Two-step syntheses of fused quinoxaline-benzodiazepines and bis-benzodiazepines employing a double UDC (Ugi/Deprotect/Cyclize) strategy
- Preparation of hydroquinazoline scaffolds via microwave-promoted Ugi reaction and cyclization
- Preparation of pyrazinone inhibitors of mast cell tryptase
Uses
Tert-Butyl 2-(aminomethyl)phenylcarbamate can be used as reactant for Two-step syntheses of fused quinoxaline-benzodiazepines and bis-benzodiazepines employing a double UDC (Ugi/Deprotect/Cyclize)
Synthesis
24424-99-5
4403-69-4
849020-94-6
Example 1 Synthesis of tert-butyl N-[2-(aminomethyl)phenyl]carbamate: To an anhydrous dichloromethane (30 mL) solution of 2-aminobenzylamine (2.440 g, 20.0 mmol), an anhydrous dichloromethane (12 mL) solution of di-tert-butyl dicarbonate (4.360 g, 20.0 mmol) was slowly added dropwise over a period of minutes at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC) with ethyl acetate: hexane (1:1) as the unfolding agent, and the completion of the reaction was confirmed after about 30 minutes. Subsequently, the volatile solvent was removed by rotary evaporation, and the resulting solid was purified by fast column chromatography with the eluent ethyl acetate-hexane (initial ratio 1.5:8.5, gradually adjusted to 3:7), resulting in tert-butyl N-[2-(aminomethyl)phenyl]carbamate 3.912 g in 88% yield as an off-white powder, with spectral and analytical data as expected.
References
[1] Patent: US6927294, 2005, B1. Location in patent: Page/Page column 18
tert-Butyl 2-(aminomethyl)phenylcarbamate Preparation Products And Raw materials
Raw materials
Preparation Products
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