ChemicalBook > CAS DataBase List > tert-Butyl 2-(aminomethyl)phenylcarbamate

tert-Butyl 2-(aminomethyl)phenylcarbamate

Product Name: tert-Butyl 2-(aminomethyl)phenylcarbamate
CAS No.: 849020-94-6
Chemical Name: tert-Butyl 2-(aminomethyl)phenylcarbamate
Synonyms: 2-(Boc-amino)benzylamine;2-(Aminomethyl)-N-Boc-aniline;2-(tert-Butoxycarbonylamino)benzylamine;2-(Aminomethyl)aniline, 1-BOC protected;TERT-BUTYL 2-(AMINOMETHYL)PHENYLCARBAMATE;ert-Butyl N-(2-aminomethylphenyl)carbamate;2-(Aminomethyl)aniline, 1-BOC protected 95+%;tert-Butyl N-[2-(aminomethyl)phenyl]carbamate;2-(Aminomethyl)-N-(tert-butoxycarbonyl)aniline;tert-Butyl 2-(aminomethyl)phenylcarbamate ISO 9001：2015 REACH
CBNumber: CB61096637
Molecular Formula: C12H18N2O2
Formula Weight: 222.28
MOL File: 849020-94-6.mol

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tert-Butyl 2-(aminomethyl)phenylcarbamate Property

Boiling point:: 238-242℃
Density: 1.054g/mLat 25℃
Flash point:: 71°C
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: liquid
pka: 13.67±0.70(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22-43
Safety Statements: 36/37
RIDADR: NA 1993 / PGIII
WGK Germany: 3
HS Code: 2921490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 709700
Product name: 2-(Boc-amino)benzylamine
Packaging: 1g
Price: $115.9
Updated: 2025/07/31

TRC

Product number: T206103
Product name: tert-Butyl2-(Aminomethyl)phenylcarbamate
Packaging: 500mg
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB50901
Product name: tert-Butyl 2-(aminomethyl)phenylcarbamate
Packaging: 5G
Price: $547.4
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0032240
Product name: TERT-BUTYL 2-(AMINOMETHYL)PHENYLCARBAMATE
Purity: 95.00%
Packaging: 1G
Price: $730.31
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4648-1-Y3
Product name: 2-(Aminomethyl)aniline, 1-Boc protected
Packaging: 5G
Price: $871
Updated: 2021/12/16

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tert-Butyl 2-(aminomethyl)phenylcarbamate Chemical Properties,Usage,Production

Uses

Reactant for:

Two-step syntheses of fused quinoxaline-benzodiazepines and bis-benzodiazepines employing a double UDC (Ugi/Deprotect/Cyclize) strategy
Preparation of hydroquinazoline scaffolds via microwave-promoted Ugi reaction and cyclization
Preparation of pyrazinone inhibitors of mast cell tryptase

Uses

Tert-Butyl 2-(aminomethyl)phenylcarbamate can be used as reactant for Two-step syntheses of fused quinoxaline-benzodiazepines and bis-benzodiazepines employing a double UDC (Ugi/Deprotect/Cyclize)

Synthesis

24424-99-5

4403-69-4

849020-94-6

Example 1 Synthesis of tert-butyl N-[2-(aminomethyl)phenyl]carbamate: To an anhydrous dichloromethane (30 mL) solution of 2-aminobenzylamine (2.440 g, 20.0 mmol), an anhydrous dichloromethane (12 mL) solution of di-tert-butyl dicarbonate (4.360 g, 20.0 mmol) was slowly added dropwise over a period of minutes at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC) with ethyl acetate: hexane (1:1) as the unfolding agent, and the completion of the reaction was confirmed after about 30 minutes. Subsequently, the volatile solvent was removed by rotary evaporation, and the resulting solid was purified by fast column chromatography with the eluent ethyl acetate-hexane (initial ratio 1.5:8.5, gradually adjusted to 3:7), resulting in tert-butyl N-[2-(aminomethyl)phenyl]carbamate 3.912 g in 88% yield as an off-white powder, with spectral and analytical data as expected.

References

[1] Patent: US6927294, 2005, B1. Location in patent: Page/Page column 18

tert-Butyl 2-(aminomethyl)phenylcarbamate Preparation Products And Raw materials

Raw materials

Preparation Products

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849020-94-6, tert-Butyl 2-(aminomethyl)phenylcarbamateRelated Search:

Phenyl carbamate tert-Butyl 2-(aminomethyl)phenylcarbamate FMOC-LYS(MEABZ-BOC)-OH FMOC-LYS(RETRO-ABZ-BOC)-OH 5-AMINO-2,3,4,5-TETRAHYDRO-BENZO[B]AZEPINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL 4-AMINO-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE 4-AMINO-1-N-BOC-5,7-DICHLORO-1,2,3,4-TETRAHYDROQUINOLINE tert-butyl 6-(aminomethyl)-2,3-dihydrobenzo[b][1,4]dioxin-5-ylcarbamate tert-butyl 2-(aminomethyl)-3-(trifluoromethoxy)phenylcarbamate tert-butyl 2-(aminomethyl)-5-(trifluoromethoxy)phenylcarbamate [2-(MORPHOLINE-4-CARBONYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER [2-(1-AMINO-ETHYL)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER FMOC-LYS(RETRO-ABZ-N-ME-BOC)-OH tert-butyl 6-(aminomethyl)-2,3-dihydrobenzo[b][1,4]dioxin-7-ylcarbamate tert-butyl 2-(aminomethyl)-5-methoxyphenylcarbamate Tert-butyl 2-(aminomethyl)-4,5-dimethoxyphenylcarbamate (2-PIPERIDIN-2-YL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER 4-AMINO-3-(FMOC-AMINOMETHYL)-BENZOIC ACID

2-(Aminomethyl)aniline, 1-BOC protected

2-[(tert-Butoxycarbonyl)amino]benzylamine, tert-Butyl [2-(aminomethyl)phenyl]carbamate

tert-Butyl N-[2-(aminomethyl)phenyl]carbamate

2-(tert-Butoxycarbonylamino)benzylamine

2-(Boc-amino)benzylamine

2-(Aminomethyl)-N-Boc-aniline

TERT-BUTYL 2-(AMINOMETHYL)PHENYLCARBAMATE

ert-Butyl N-(2-aminomethylphenyl)carbamate

2-(Aminomethyl)aniline, 1-BOC protected 95+%

Carbamic acid, N-[2-(aminomethyl)phenyl]-, 1,1-dimethylethyl ester

tert-Butyl 2-(aminomethyl)phenylcarbamate ISO 9001：2015 REACH

2-(Aminomethyl)-N-(tert-butoxycarbonyl)aniline

849020-94-6

Building Blocks

Chemical Synthesis

Nitrogen Compounds

Organic Building Blocks

Polyamines

Protected Amines