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Methyl-4,5-dibromo-2-furoate

Product Name
Methyl-4,5-dibromo-2-furoate
CAS No.
54113-41-6
Chemical Name
Methyl-4,5-dibromo-2-furoate
Synonyms
Methyl-4,5-dibromo-2-furoate;Methyl 4,5-Dibromo-2-furancarboxylate;methyl 4,5-dibromofuran-2-carboxylate;4,5-Dibromo-2-furoic Acid Methyl Ester;4,5-Dibromofuran-2-carboxylicacid methyl ester;4,5-Dibromo-2-furancarboxylic Acid Methyl Ester;2-Furancarboxylic acid, 4,5-dibromo-, methyl ester
CBNumber
CB61105874
Molecular Formula
C6H4Br2O3
Formula Weight
283.9
MOL File
54113-41-6.mol
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Methyl-4,5-dibromo-2-furoate Property

Melting point:
56.0 to 60.0 °C
Boiling point:
110°C/0.8mmHg(lit.)
Density 
1.992±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform, Dichloromethane, Ethyl Acetate, Methanol
form 
Solid
color 
Off White
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Safety

HS Code 
2932190090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2876
Product name
Methyl 4,5-Dibromo-2-furancarboxylate
Purity
>95.0%(GC)
Packaging
1g
Price
$190
Updated
2025/07/31
Usbiological
Product number
455577
Product name
Methyl 4,5-Dibromo-2-furoate
Packaging
1g
Price
$368
Updated
2021/12/16
TRC
Product number
M295320
Product name
Methyl4,5-Dibromo-2-furoate
Packaging
1g
Price
$90
Updated
2021/12/16
Apolloscientific
Product number
OR916713
Product name
Methyl4,5-dibromo-2-furoate
Packaging
1g
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-0011220
Product name
Methyl4,5-dibromofuran-2-carboxylate
Packaging
1g
Price
$136
Updated
2021/12/16
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Methyl-4,5-dibromo-2-furoate Chemical Properties,Usage,Production

Uses

Methyl 4,5-dibromo-2-furoate is an intermediate in the synthesis of 4-Amino-2-furancarboxylic Acid (A609680), which is the characteristic structural element of the Proximicins. Proximicin A, B and C, are novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora.

Synthesis

67-56-1

2434-03-9

54113-41-6

Preparative Example 2-1 Synthesis of methyl 4,5-dibromofuran-2-carboxylate Procedure: a catalytic amount of oxalyl chloride (210 μL, 2.4 mmol) was added slowly and dropwise to a mixed solution of dichloromethane (5.0 mL) and N,N-dimethylformamide containing 4,5-dibromofuran-2-carboxylic acid (500 mg, 1.9 mmol) at 0 °C. The reaction mixture was stirred at room temperature for 1 hour. Subsequently, the solvent was removed by distillation under reduced pressure, triethylamine (340 μL, 2.4 mmol) and methanol (4.0 mL) were added, and stirring was continued for 1 h at room temperature. Upon completion of the reaction, the solvent was again removed by distillation under reduced pressure, saturated aqueous sodium bicarbonate was added, and extraction was carried out with ethyl acetate. The organic layer was washed sequentially with water and saturated brine and dried with anhydrous sodium sulfate. Finally, the solvent was removed by reduced pressure distillation to afford the target product methyl 4,5-dibromofuran-2-carboxylate (460 mg, 88% yield). The product was characterized by 1H-NMR (400 MHz, CDCl3) with chemical shifts δ (ppm) of 3.90 (s, 3H), 7.18 (s, 1H).

References

[1] Patent: US2006/160874, 2006, A1. Location in patent: Page/Page column 21
[2] Patent: WO2004/7504, 2004, A1. Location in patent: Page 54-55
[3] Patent: WO2008/98104, 2008, A1. Location in patent: Page/Page column 216-217
[4] Patent: US2016/168176, 2016, A1. Location in patent: Paragraph 0241; 0242

Methyl-4,5-dibromo-2-furoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl-4,5-dibromo-2-furoate Suppliers

Americas 1 China 64 Europe 1 France 1 Germany 1 India 3 Japan 1 Ukraine 1 United Kingdom 1 United States 11 Global 85
Rare Chemicals GmbH
Tel
--
Fax
--
Email
sales@rarechem.de
Country
Germany
ProdList
6297
Advantage
38
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View Lastest Price from Methyl-4,5-dibromo-2-furoate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Methyl 4,5-dibromo-2-furoate 54113-41-6
Price
US $1.60-6.60/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-19
Career Henan Chemical Co
Product
Methyl-4,5-dibromo-2-furoate 54113-41-6
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-17

54113-41-6, Methyl-4,5-dibromo-2-furoateRelated Search:

2-Furoic acid 4,5-diethylbenzene-1,2-diamine 4,5-DIBROMOTHIOPHENE-2-CARBOXALDEHYDE 4,5-Dihydro-thieno[2,3-o]pyran-7,-one METHYL4,5-DIBROMOTHIOPHENE-2-CARBOXYLATE 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine 4,5-DICHLOROPYRIMIDINE 2,3-DIBROMOFURAN METHYL 5-BROMO-2-FUROATE 3-Bromofuran 2,3-Dibromofuran-5-carboxylic acid 2-Bromofuran 5-Bromo-2-furaldehyde 4-Bromo-2-furaldehyde 4,5-Dibromo-2-furaldehyde 5-Bromofuroic acid Methyl-4,5-dibromo-2-furoate METHYL FUROATE

  • Methyl-4,5-dibromo-2-furoate
  • 4,5-Dibromofuran-2-carboxylicacid methyl ester
  • methyl 4,5-dibromofuran-2-carboxylate
  • Methyl 4,5-Dibromo-2-furancarboxylate
  • 2-Furancarboxylic acid, 4,5-dibromo-, methyl ester
  • 4,5-Dibromo-2-furancarboxylic Acid Methyl Ester
  • 4,5-Dibromo-2-furoic Acid Methyl Ester
  • 54113-41-6
  • C6H4Br2O3