ChemicalBook > CAS DataBase List > 1,4-Oxazepan-5-one

1,4-Oxazepan-5-one

Product Name
1,4-Oxazepan-5-one
CAS No.
10341-26-1
Chemical Name
1,4-Oxazepan-5-one
Synonyms
1,4-OXAZEPAN-5-ONE;1,4-Oxaxepan-5-one;Homomorpholin-5-one;HoMoMorpholine-5-one;tetrahydro-1,4-Oxazepin-5(2H)-one;tetrahydro-(2H)-1,4-oxazepin-5-one;1,4-Oxazepin-5(2H)-one, tetrahydro-
CBNumber
CB61116551
Molecular Formula
C5H9NO2
Formula Weight
115.13
MOL File
10341-26-1.mol
More
Less

1,4-Oxazepan-5-one Property

Melting point:
80-82°C
Boiling point:
165 °C(Press: 15 Torr)
Density 
1.068±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
15.85±0.20(Predicted)
Appearance
Off-white to yellow Solid
Sensitive 
Hygroscopic
InChI
InChI=1S/C5H9NO2/c7-5-1-3-8-4-2-6-5/h1-4H2,(H,6,7)
InChIKey
OXDIYMHNQAWSCL-UHFFFAOYSA-N
SMILES
O1CCC(=O)NCC1
More
Less

Safety

PackingGroup 
III
HS Code 
2934999090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TRC
Product number
O990093
Product name
1,4-Oxazepan-5-one
Packaging
250mg
Price
$90
Updated
2021/12/16
Apolloscientific
Product number
OR46126
Product name
1,4-Oxazepan-5-one
Packaging
1g
Price
$95
Updated
2021/12/16
AK Scientific
Product number
0717AP
Product name
1,4-Oxazepan-5-one
Packaging
1g
Price
$122
Updated
2021/12/16
Apolloscientific
Product number
OR46126
Product name
1,4-Oxazepan-5-one
Packaging
5g
Price
$311
Updated
2021/12/16
AK Scientific
Product number
0717AP
Product name
1,4-Oxazepan-5-one
Packaging
5g
Price
$339
Updated
2021/12/16
More
Less

1,4-Oxazepan-5-one Chemical Properties,Usage,Production

Uses

Used as a pharmaceutical intermediate.

Synthesis

61128-73-2

10341-26-1

General procedure for the synthesis of 1,4-oxoazepan-5-one from dihydro-2H-pyran-4(3H)-one oxime: to a solution of tetrahydrofuran (THF, 10 mL) containing the ketoxime (0.01 mol) was added T3P (15 mol%, 50% solution in ethyl acetate). The reaction mixture was heated to reflux and stirred for 1-4 h under nitrogen protection. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the solvent was removed under reduced pressure. The residue was diluted with distilled water (20 mL) and subsequently extracted with ethyl acetate (2 x 20 mL). The organic phases were combined and washed sequentially with saturated sodium bicarbonate (NaHCO3) solution (1 × 10 mL) and brine. The organic phase was dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give a high purity target amide product.

References

[1] Tetrahedron Letters, 2011, vol. 52, # 10, p. 1074 - 1077
[2] Patent: WO2012/101654, 2012, A2. Location in patent: Page/Page column 67-68
[3] Zhurnal Obshchei Khimii, 1955, vol. 25, p. 133,135; engl. Ausg. S. 119, 121
[4] Zhurnal Obshchei Khimii, 1955, vol. 25, p. 133,135; engl. Ausg. S. 119, 121
[5] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 19, p. 2651 - 2653

1,4-Oxazepan-5-one Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1,4-Oxazepan-5-one Suppliers

China 99 Germany 1 India 4 United States 7 Global 111
Milestone Chemical Wuxi Co.,Ltd
Tel
18068271528
Email
1917265470@qq.com
Country
China
ProdList
72
Advantage
58
SuZhou Medinoah Co.,LTD.
Tel
0512-69561983 13914027025
Fax
0512-69561982
Email
zhang_q@medinoah.com
Country
China
ProdList
3811
Advantage
58
Cangzhou Dimai Technology Co., Ltd
Tel
1351-2466848 13512466848
Fax
QQ:94204388
Email
hbdypharm@163.com
Country
China
ProdList
244
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Enantiotech Corporation Ltd
Tel
760-85282375 13212762451
Email
marketing@enantiotech.net
Country
China
ProdList
139
Advantage
55
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Chengdu HappySyn Pharmaceutical Technology Co., Ltd.
Tel
028-85114309 18982182443
Email
yangli@happysyn.com
Country
China
ProdList
2150
Advantage
55
More
Less

View Lastest Price from 1,4-Oxazepan-5-one manufacturers

Shanghai Rlavie Technology Co ltd
Product
1,4-Oxazepan-5-one 10341-26-1
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
50kgs/month
Release date
2021-11-20

10341-26-1, 1,4-Oxazepan-5-oneRelated Search:

TIMENTIN 2-(3,4-Dihydroxy-2,5-diaminopentanoylamino)-3-(7-oxo-4-oxa-1-azabicyclo[3.2.0]heptan-3-yl)-3-hydroxypropionic acid CLAVULANIC ACID METHYL ESTER-D3 7-OXO-4-OXA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLATE 1,4-Oxazepan-5-one CLASTO-LACTACYSTIN CALISTO-LACTONE CLAVULANIC ACID AMMONIUM 2-[5-(Acetylamino)-2-aminopentanoylamino]-3-(7-oxo-4-oxa-1-azabicyclo[3.2.0]heptan-3-yl)-3-hydroxypropionic acid ALPHA-METHYL CLASTO-LACTACYSTIN BETA-LACTONE Clavulanic acid Timentin AMOXYCILLIN SODIUM/POTASSIUM CLAVULANATE Amoxicillin and clavulanate potassium(4:1) AMOXICILLIN, CLAVULANATE POTASSIUM(4:1)

  • 1,4-Oxaxepan-5-one
  • HoMoMorpholine-5-one
  • tetrahydro-1,4-Oxazepin-5(2H)-one
  • Homomorpholin-5-one
  • tetrahydro-(2H)-1,4-oxazepin-5-one
  • 1,4-Oxazepin-5(2H)-one, tetrahydro-
  • 1,4-OXAZEPAN-5-ONE
  • 10341-26-1