ChemicalBook > CAS DataBase List > 1,4-Oxazepan-5-one

1,4-Oxazepan-5-one

Product Name: 1,4-Oxazepan-5-one
CAS No.: 10341-26-1
Chemical Name: 1,4-Oxazepan-5-one
Synonyms: 1,4-OXAZEPAN-5-ONE;1,4-Oxaxepan-5-one;Homomorpholin-5-one;HoMoMorpholine-5-one;tetrahydro-1,4-Oxazepin-5(2H)-one;tetrahydro-(2H)-1,4-oxazepin-5-one;1,4-Oxazepin-5(2H)-one, tetrahydro-
CBNumber: CB61116551
Molecular Formula: C5H9NO2
Formula Weight: 115.13
MOL File: 10341-26-1.mol

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1,4-Oxazepan-5-one Property

Melting point:: 80-82°C
Boiling point:: 165 °C(Press: 15 Torr)
Density: 1.068±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 15.85±0.20(Predicted)
Appearance: Off-white to yellow Solid
Sensitive: Hygroscopic
InChI: InChI=1S/C5H9NO2/c7-5-1-3-8-4-2-6-5/h1-4H2,(H,6,7)
InChIKey: OXDIYMHNQAWSCL-UHFFFAOYSA-N
SMILES: O1CCC(=O)NCC1

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Safety

PackingGroup: III
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: O990093
Product name: 1,4-Oxazepan-5-one
Packaging: 250mg
Price: $90
Updated: 2021/12/16

Apolloscientific

Product number: OR46126
Product name: 1,4-Oxazepan-5-one
Packaging: 1g
Price: $95
Updated: 2021/12/16

AK Scientific

Product number: 0717AP
Product name: 1,4-Oxazepan-5-one
Packaging: 1g
Price: $122
Updated: 2021/12/16

Apolloscientific

Product number: OR46126
Product name: 1,4-Oxazepan-5-one
Packaging: 5g
Price: $311
Updated: 2021/12/16

AK Scientific

Product number: 0717AP
Product name: 1,4-Oxazepan-5-one
Packaging: 5g
Price: $339
Updated: 2021/12/16

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1,4-Oxazepan-5-one Chemical Properties,Usage,Production

Uses

Used as a pharmaceutical intermediate.

Synthesis

61128-73-2

10341-26-1

General procedure for the synthesis of 1,4-oxoazepan-5-one from dihydro-2H-pyran-4(3H)-one oxime: to a solution of tetrahydrofuran (THF, 10 mL) containing the ketoxime (0.01 mol) was added T3P (15 mol%, 50% solution in ethyl acetate). The reaction mixture was heated to reflux and stirred for 1-4 h under nitrogen protection. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the solvent was removed under reduced pressure. The residue was diluted with distilled water (20 mL) and subsequently extracted with ethyl acetate (2 x 20 mL). The organic phases were combined and washed sequentially with saturated sodium bicarbonate (NaHCO3) solution (1 × 10 mL) and brine. The organic phase was dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give a high purity target amide product.

References

[1] Tetrahedron Letters, 2011, vol. 52, # 10, p. 1074 - 1077
[2] Patent: WO2012/101654, 2012, A2. Location in patent: Page/Page column 67-68
[3] Zhurnal Obshchei Khimii, 1955, vol. 25, p. 133,135; engl. Ausg. S. 119, 121
[4] Zhurnal Obshchei Khimii, 1955, vol. 25, p. 133,135; engl. Ausg. S. 119, 121
[5] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 19, p. 2651 - 2653

1,4-Oxazepan-5-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1,4-Oxazepan-5-one manufacturers

Shanghai Rlavie Technology Co ltd

Product: 1,4-Oxazepan-5-one 10341-26-1
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: 50kgs/month
Release date: 2021-11-20

10341-26-1, 1,4-Oxazepan-5-oneRelated Search:

TIMENTIN 2-(3,4-Dihydroxy-2,5-diaminopentanoylamino)-3-(7-oxo-4-oxa-1-azabicyclo[3.2.0]heptan-3-yl)-3-hydroxypropionic acid CLAVULANIC ACID METHYL ESTER-D3 7-OXO-4-OXA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLATE 1,4-Oxazepan-5-one CLASTO-LACTACYSTIN CALISTO-LACTONE CLAVULANIC ACID AMMONIUM 2-[5-(Acetylamino)-2-aminopentanoylamino]-3-(7-oxo-4-oxa-1-azabicyclo[3.2.0]heptan-3-yl)-3-hydroxypropionic acid ALPHA-METHYL CLASTO-LACTACYSTIN BETA-LACTONE Clavulanic acid Timentin AMOXYCILLIN SODIUM/POTASSIUM CLAVULANATE Amoxicillin and clavulanate potassium(4:1) AMOXICILLIN, CLAVULANATE POTASSIUM(4:1)

1,4-Oxaxepan-5-one

HoMoMorpholine-5-one

tetrahydro-1,4-Oxazepin-5(2H)-one

Homomorpholin-5-one

tetrahydro-(2H)-1,4-oxazepin-5-one

1,4-Oxazepin-5(2H)-one, tetrahydro-

1,4-OXAZEPAN-5-ONE

10341-26-1