Desirudin
- Product Name
- Desirudin
- CAS No.
- 120993-53-5
- Chemical Name
- Desirudin
- Synonyms
- K-HIR02;Desirudin
- CBNumber
- CB61116647
- Molecular Formula
- C287H440N80O110S6
- Formula Weight
- 6963.4245
- MOL File
- 120993-53-5.mol
N-Bromosuccinimide Price
- Product number
- API0009460
- Product name
- DESIRUDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.95
- Updated
- 2021/12/16
Desirudin Chemical Properties,Usage,Production
Uses
Anticoagulant.
Clinical Use
Prophylaxis of DVT in patients undergoing orthopaedic surgery
in vivo
Desirudin (CGP 39393, 0.75-3.0 mg/kg, a bolus plus infusion administration, dogs model of cardiopulmonary bypass) is effective in Inhibiting clot formation[1]. Desirudin (0.01-1 mg/kg, Intravenous injections and subcutaneous injection, rat shunt model) inhibits thrombus development with ED50 values of 0.3 mg/kg (i.v.) and 1.0 mg/kg (s.c.), and inhibits venous stasis thrombosis with ED50 values of 0.01 mg/kg (i.v.) and 0.45 mg/kg (s.c.)[2].
| Animal Model: | Male mongrel dogs model of cardiopulmonary bypass[1] |
| Dosage: | 1.0 mg/kg + 0.75 mg/kg/h, 1.0 mg/kg + 1.50 mg/kg/h, 1.0 mg/kg + 2.25 mg/kg/h, 1.0 mg/kg + 3.0 mg/kg/h. |
| Administration: | Administered as a bolus plus infusion |
| Result: | Inhibited clot formation with no adverse hemodynamic or hematologic effects. |
| Animal Model: | Rat shunt model of thrombus formation on a cotton-thread[2] |
| Dosage: | 0.01-1 mg/kg approximately |
| Administration: | Intravenous injections, subcutaneous injection |
| Result: | Inhibited thrombus development with ED50 values of 0.3 mg/kg (i.v.) and 1.0 mg/kg (s.c.). Inhibited venous stasis thrombosis with ED50 values of 0.01 mg/kg (i.v.) and 0.45 mg/kg (s.c.). |
Drug interactions
Potentially hazardous interactions with other drugs
Anticoagulants, antiplatelets, fondaparinux,
NSAIDs, heparin and dextran - increased risk of
bleeding
Metabolism
Desirudin is metabolised and excreted by the kidney, and 40-50% of a dose is excreted unchanged in the urine
Desirudin Preparation Products And Raw materials
Raw materials
Preparation Products
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