ChemicalBook > CAS DataBase List > 2-Maleimido acetic acid

2-Maleimido acetic acid

Product Name
2-Maleimido acetic acid
CAS No.
25021-08-3
Chemical Name
2-Maleimido acetic acid
Synonyms
2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid;NSC 266055;N-Maleoylglycine;N-MaleiMidoglycine;N,N-maleoyl-glycine;MALEIMIDOACETIC ACID;2-maleimide acetic acid;2-MALEIMIDO ACETIC ACID;N-(CarboxyMethyl)MaleiMide;2-MALEIMIDO ACETIC ACID 97%
CBNumber
CB61118111
Molecular Formula
C6H5NO4
Formula Weight
155.11
MOL File
25021-08-3.mol
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2-Maleimido acetic acid Property

Melting point:
114 °C(Solv: chloroform (67-66-3))
Boiling point:
376.7±25.0 °C(Predicted)
Density 
1.578±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
soluble in DMSO, Methanol
form 
powder to crystal
pka
3.31±0.10(Predicted)
color 
White to Almost white
InChI
InChI=1S/C6H5NO4/c8-4-1-2-5(9)7(4)3-6(10)11/h1-2H,3H2,(H,10,11)
InChIKey
GBKPNGVKZQBPCZ-UHFFFAOYSA-N
SMILES
N1(CC(O)=O)C(=O)C=CC1=O
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Safety

HS Code 
2925.19.4200
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M3143
Product name
2-Maleimidoacetic Acid
Purity
>98.0%(HPLC)(T)
Packaging
50mg
Price
$65
Updated
2024/03/01
TCI Chemical
Product number
M3143
Product name
2-Maleimidoacetic Acid
Purity
>98.0%(HPLC)(T)
Packaging
250mg
Price
$191
Updated
2024/03/01
TRC
Product number
M124990
Product name
MaleimidoaceticAcid
Packaging
250mg
Price
$135
Updated
2021/12/16
Matrix Scientific
Product number
119970
Product name
2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid
Purity
95+%
Packaging
1g
Price
$810
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0155638
Product name
2-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1-YL)ACETIC ACID
Purity
95.00%
Packaging
1G
Price
$925.31
Updated
2021/12/16
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2-Maleimido acetic acid Chemical Properties,Usage,Production

Chemical Properties

White to Almost white powder to crystal or Pale Yellow Solid.

Uses

Maleimidoacetic Acid (CAS# 25021-08-3) is a heterocyclic organic compound that has a variety of uses in organic synthesis. It contains both a maleimide and carboxylic acid functional group, making it a versatile reagent for coupling reactions with amine-containing compounds.

Application

2-Maleimido acetic acid is a maleimide-containing ligand that could be used to produce the cisplatin-based Pt(IV) complexes (OC-6-44)-diamminedichlorido(ethanolato)(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetato)platinum(IV) and (OC-6-44)-acetatodiamminedichlorido(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetato)platinum(IV). The Pt(IV) complexes are considered to act as antitumor prodrugs and their in vivo activity can be improved by exploiting drug targeting and delivery strategies[1]. In this case,  conjugation between maleimide-containing Pt(IV) prodrugs and furan or furan-containing drug delivery vectors via Diels-Alder cycloaddition.

References

[1] Gabano E, et al. Conjugation between maleimide-containing Pt(IV) prodrugs and furan or furan-containing drug delivery vectors via Diels-Alder cycloaddition. Inorganica Chimica Acta, 2019; 488: 195-200.

2-Maleimido acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Maleimido acetic acid Suppliers

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View Lastest Price from 2-Maleimido acetic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Maleimido acetic acid 25021-08-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Maleimido acetic acid 25021-08-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08
Career Henan Chemical Co
Product
2-Maleimido acetic acid 25021-08-3
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

25021-08-3, 2-Maleimido acetic acidRelated Search:

DISUCCINIMIDYL SUBERATE Suberate Bis(sulfosuccinimidyl) Sodium Salt N-Succinimidyl maleimidoacetate 3-(BENZOPHENONE-4-CARBOXAMIDO)-2-MALEIMIDOPROPANOIC ACID 2-Maleimido acetic acid 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-4-methanesulfonylbutanoic acid 2-(2,5-DIOXO-2,5-DIHYDRO-PYRROL-1-YL)-PROPIONIC ACID 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanoic acid 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-methylbutanoic acid DACM 3-MALEIMIDO-4-METHYL-6,7-METHYLENEDIOXYCOUMARIN RARECHEM AL CD 0491 4-carbamoyl-2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoic acid 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-methylpentanoic acid 9-ACETOXY-2-(4-(2,5-DIHYDRO-2,5-DIOXO-1H-PYRROL-1-YL)-3-OXO-3-H-NAPHTHO[2,1-B]PYRAN 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-(1H-imidazol-4-yl)propanoic acid 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-4-methylpentanoic acid methyl 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetate

  • 2-MALEIMIDOACETIC ACID DIHYDRATE
  • N-Maleoylglycine
  • 2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-acetic Acid
  • N-(CarboxyMethyl)MaleiMide
  • N-MaleiMidoglycine
  • NSC 266055
  • 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid
  • MAA 2-Maleimido acetic acid
  • 2-MALEIMIDO ACETIC ACID 97%
  • 2-(2,5-dioxopyrrol-1-yl)acetic acid
  • 2-Maleimido acetic acid(MAA)
  • 1H-Pyrrole-1-acetic acid, 2,5-dihydro-2,5-dioxo-
  • 2-maleimide acetic acid
  • 2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-acetic acid
  • MALEIMIDOACETIC ACID
  • 2-MALEIMIDO ACETIC ACID
  • N,N-maleoyl-glycine
  • 25021-08-3
  • Organic Building Blocks
  • Heterocycles
  • Intermediates