(R)-1-N-BOC-PIPERIDINE-2-ETHANOL

Product Name: (R)-1-N-BOC-PIPERIDINE-2-ETHANOL
CAS No.: 250249-85-5
Chemical Name: (R)-1-N-BOC-PIPERIDINE-2-ETHANOL
Synonyms: (R)-1-N-BOC-PIPERIDINE-2-ETHANOL - PRODUCT;(R)-tert-Butyl2-(2-hydroxyethyl)piperidine-1-carboxylate;tert-Butyl (R)-2-(2-Hydroxyethyl)piperidine-1-carboxylate;tert-butyl (2R)-2-(2-hydroxyethyl)piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 2-(2-hydroxyethyl)-, 1,1-dimethylethyl ester, (2R)-
CBNumber: CB61118575
Molecular Formula: C12H23NO3
Formula Weight: 229.32
MOL File: 250249-85-5.mol

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(R)-1-N-BOC-PIPERIDINE-2-ETHANOL Property

Boiling point:: 324.1±15.0 °C(Predicted)
Density: 1.043
storage temp.: Sealed in dry,Room Temperature
pka: 15.15±0.10(Predicted)
Appearance: Colorless to light yellow Liquid
optical activity: 52.4°(C=0.9g/100ml CHCL3)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: B663893
Product name: (R)-1-N-Boc-piperidine-2-ethanol
Packaging: 50mg
Price: $65
Updated: 2021/12/16

TRC

Product number: B663893
Product name: (R)-1-N-Boc-piperidine-2-ethanol
Packaging: 100mg
Price: $90
Updated: 2021/12/16

Activate Scientific

Product number: AS47136
Product name: (R)-1-Boc-piperidine-2-ethanol
Purity: 97% ee
Packaging: 1g
Price: $178
Updated: 2021/12/16

AK Scientific

Product number: 9447BA
Product name: (R)-1-N-Boc-piperidine-2-ethanol
Packaging: 25g
Price: $281
Updated: 2021/12/16

Activate Scientific

Product number: AS47136
Product name: (R)-1-Boc-piperidine-2-ethanol
Purity: 97% ee
Packaging: 5G
Price: $606
Updated: 2021/12/16

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(R)-1-N-BOC-PIPERIDINE-2-ETHANOL Chemical Properties,Usage,Production

Synthesis

351410-32-7

250249-85-5

General procedure for the synthesis of (R)-1-N-Boc-piperidin-2-yl-ethanol from (R)-2-(1-(tert-butoxycarbonyl)piperidin-2-yl)acetic acid: to a solution of (R)-2-(1-(tert-butoxycarbonyl)piperidin-2-yl)acetic acid (2.0 g, 8.7 mmol) in anhydrous CH2Cl2 (20 mL) was added drop-wise a lithium aluminium hydride 2.0 M THF solution (7.23 mL, 13.05 mmol). The reaction mixture was heated to 55 °C under argon protection and stirred for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate (20 mL) and the reaction was quenched with saturated NaHCO3 solution (3 mL). Subsequently, the solution was concentrated under reduced pressure. CH2Cl2 (20 mL) was added to the residue, and the organic layer was washed sequentially with water and brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure to afford (R)-1-N-Boc-piperidin-2-ethanol (1.72 g, 8.0 mmol) as a light-colored oil in 91.9% yield. The same method was applied to synthesize intermediates 7-10.

References

[1] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 790 - 804

(R)-1-N-BOC-PIPERIDINE-2-ETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-1-N-BOC-PIPERIDINE-2-ETHANOL Suppliers

China 55 India 2 Japan 1 Switzerland 1 United Kingdom 1 United States 6 Global 66

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View Lastest Price from (R)-1-N-BOC-PIPERIDINE-2-ETHANOL manufacturers

Career Henan Chemical Co

Product: tert-butyl (2R)-2-(2-hydroxyethyl)piperidine-1-carboxylate 250249-85-5
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g;1kg； 25kg
Release date: 2020-01-09

250249-85-5, (R)-1-N-BOC-PIPERIDINE-2-ETHANOL Related Search:

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(R)-1-N-BOC-PIPERIDINE-2-ETHANOL - PRODUCT

250249-85-5

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