(R)-1-N-BOC-PIPERIDINE-2-ETHANOL
- Product Name
- (R)-1-N-BOC-PIPERIDINE-2-ETHANOL
- CAS No.
- 250249-85-5
- Chemical Name
- (R)-1-N-BOC-PIPERIDINE-2-ETHANOL
- Synonyms
- (R)-1-N-BOC-PIPERIDINE-2-ETHANOL - PRODUCT;(R)-tert-Butyl2-(2-hydroxyethyl)piperidine-1-carboxylate;tert-Butyl (R)-2-(2-Hydroxyethyl)piperidine-1-carboxylate;tert-butyl (2R)-2-(2-hydroxyethyl)piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 2-(2-hydroxyethyl)-, 1,1-dimethylethyl ester, (2R)-
- CBNumber
- CB61118575
- Molecular Formula
- C12H23NO3
- Formula Weight
- 229.32
- MOL File
- 250249-85-5.mol
(R)-1-N-BOC-PIPERIDINE-2-ETHANOL Property
- Boiling point:
- 324.1±15.0 °C(Predicted)
- Density
- 1.043
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 15.15±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
- optical activity
- 52.4°(C=0.9g/100ml CHCL3)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B663893
- Product name
- (R)-1-N-Boc-piperidine-2-ethanol
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B663893
- Product name
- (R)-1-N-Boc-piperidine-2-ethanol
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- AS47136
- Product name
- (R)-1-Boc-piperidine-2-ethanol
- Purity
- 97% ee
- Packaging
- 1g
- Price
- $178
- Updated
- 2021/12/16
- Product number
- 9447BA
- Product name
- (R)-1-N-Boc-piperidine-2-ethanol
- Packaging
- 25g
- Price
- $281
- Updated
- 2021/12/16
- Product number
- AS47136
- Product name
- (R)-1-Boc-piperidine-2-ethanol
- Purity
- 97% ee
- Packaging
- 5G
- Price
- $606
- Updated
- 2021/12/16
(R)-1-N-BOC-PIPERIDINE-2-ETHANOL Chemical Properties,Usage,Production
Synthesis
351410-32-7
250249-85-5
General procedure for the synthesis of (R)-1-N-Boc-piperidin-2-yl-ethanol from (R)-2-(1-(tert-butoxycarbonyl)piperidin-2-yl)acetic acid: to a solution of (R)-2-(1-(tert-butoxycarbonyl)piperidin-2-yl)acetic acid (2.0 g, 8.7 mmol) in anhydrous CH2Cl2 (20 mL) was added drop-wise a lithium aluminium hydride 2.0 M THF solution (7.23 mL, 13.05 mmol). The reaction mixture was heated to 55 °C under argon protection and stirred for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate (20 mL) and the reaction was quenched with saturated NaHCO3 solution (3 mL). Subsequently, the solution was concentrated under reduced pressure. CH2Cl2 (20 mL) was added to the residue, and the organic layer was washed sequentially with water and brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure to afford (R)-1-N-Boc-piperidin-2-ethanol (1.72 g, 8.0 mmol) as a light-colored oil in 91.9% yield. The same method was applied to synthesize intermediates 7-10.
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 790 - 804
(R)-1-N-BOC-PIPERIDINE-2-ETHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-1-N-BOC-PIPERIDINE-2-ETHANOL Suppliers
- Tel
- --
- Fax
- --
- welcome@biosynth.ch
- Country
- Switzerland
- ProdList
- 3324
- Advantage
- 72
View Lastest Price from (R)-1-N-BOC-PIPERIDINE-2-ETHANOL manufacturers
- Product
- tert-butyl (2R)-2-(2-hydroxyethyl)piperidine-1-carboxylate 250249-85-5
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g;1kg； 25kg
- Release date
- 2020-01-09