ChemicalBook > CAS DataBase List > 4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE
4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE
- Product Name
- 4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE
- CAS No.
- 25392-41-0
- Chemical Name
- 4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE
- Synonyms
- BlueCMHC;EOS-61059;AKOS BBS-000001;AKOS BBS-00000158;OTAVA-BB BB7014350028;CELLTRACKER(TM) BLUE CMHC;ViVidFluor Cell Blue CMHC;4-(CHLOROMETHYL)-7-HYDROXYCOUMARIN;4-CHLOROMETHYL-7-HYDROXY-CHROMEN-2-ONE;4-(chloromethyl)-7-hydroxy-2-chromenone
- CBNumber
- CB6112215
- Molecular Formula
- C10H7ClO3
- Formula Weight
- 210.61
- MOL File
- 25392-41-0.mol
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4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE Property
- Melting point:
- 180-183°C
- Boiling point:
- 409.6±45.0 °C(Predicted)
- Density
- 1.442±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Solid
- pka
- 7.72±0.20(Predicted)
- color
- Off-white to pink
- Appearance
- Solid Powder
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Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2932209090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- C4079
- Product name
- 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $237
- Updated
- 2025/07/31
TRC
- Product number
- C598288
- Product name
- 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 037924
- Product name
- 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one
- Packaging
- 500mg
- Price
- $97
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 037924
- Product name
- 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
AK Scientific
- Product number
- W4875
- Product name
- 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one
- Packaging
- 1g
- Price
- $168
- Updated
- 2021/12/16
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4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE Chemical Properties,Usage,Production
Description
4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one is a thiol-reactive, cell-permeant fluorescent probe that easily passes through cell membranes.
Uses
Fluorescent Thiol-Reactive cell permeant probe
Synthesis
638-07-3
108-46-3
25392-41-0
A mixture of resorcinol (1.0 mmol), ethyl 4-chloroacetoacetate (1.5 mmol) and MNESA (0.075 g) was placed in a round-bottomed flask and the reaction was stirred at 90 °C. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction mixture was cooled to room temperature. The catalyst MNESA was separated from the reaction mixture using an external magnetic field. Subsequently, water was added to the reaction mixture and the target product, 4-chloromethyl-7-hydroxychromen-2-one, was extracted with ethyl acetate (EtOAc, 3 × 10 mL). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give the crude product. For further purification, the crude product was recrystallized in ethanol to obtain high purity 4-chloromethyl-7-hydroxychromen-2-one.
References
[1] Tetrahedron Letters, 2005, vol. 46, # 36, p. 6119 - 6121
[2] Journal of Organic Chemistry, 2008, vol. 73, # 1, p. 287 - 290
[3] Synthetic Communications, 2008, vol. 38, # 13, p. 2082 - 2088
[4] Journal of Chemical Research, 2008, # 4, p. 232 - 234
[5] Synthetic Communications, 2010, vol. 40, # 22, p. 3358 - 3364
Excitation / Emission Maximum
348 nm/423 nm
4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE manufacturers
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one 25392-41-0
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99% min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
Career Henan Chemical Co
- Product
- 4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE 25392-41-0
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-10
25392-41-0, 4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONERelated Search:
4-CHLOROMETHYL-6-HYDROXY-7-METHYL-CHROMEN-2-ONE
8-CHLOROMETHYL-[1,3]DIOXOLO[4,5-G]CHROMEN-6-ONE
4-(CHLOROMETHYL)-6-ETHYL-7-HYDROXY-2H-CHROMEN-2-ONE
6-CHLORO-4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE
4-(chloromethyl)-6,7-dihydroxy-2-benzopyrone
4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE
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4-CHLOROMETHYL-7-HYDROXY-8-METHYL-CHROMEN-2-ONE
4-(1-CHLOROETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE
4-CHLOROMETHYL-7-METHOXY-CHROMEN-2-ONE
AKOS BBS-00001305
4-CHLOROMETHYL-6,8-DIFLUORO-7-ETHOXYCOUMARIN