4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE

Product Name: 4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE
CAS No.: 25392-41-0
Chemical Name: 4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE
Synonyms: BlueCMHC;EOS-61059;AKOS BBS-000001;AKOS BBS-00000158;OTAVA-BB BB7014350028;CELLTRACKER(TM) BLUE CMHC;ViVidFluor Cell Blue CMHC;4-(CHLOROMETHYL)-7-HYDROXYCOUMARIN;4-CHLOROMETHYL-7-HYDROXY-CHROMEN-2-ONE;4-(chloromethyl)-7-hydroxy-2-chromenone
CBNumber: CB6112215
Molecular Formula: C10H7ClO3
Formula Weight: 210.61
MOL File: 25392-41-0.mol

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4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE Property

Melting point:: 180-183°C
Boiling point:: 409.6±45.0 °C(Predicted)
Density: 1.442±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: Solid
pka: 7.72±0.20(Predicted)
color: Off-white to pink
Appearance: Solid Powder

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2932209090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C4079
Product name: 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one
Purity: min. 98.0 %
Packaging: 1G
Price: $237
Updated: 2025/07/31

TRC

Product number: C598288
Product name: 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 037924
Product name: 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one
Packaging: 500mg
Price: $97
Updated: 2021/12/16

Matrix Scientific

Product number: 037924
Product name: 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one
Packaging: 1g
Price: $150
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H25-5-01
Product name: 4-(Chloromethyl)-7-hydroxycoumarin
Purity: 97%
Packaging: 1g
Price: $256
Updated: 2021/12/16

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4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE Chemical Properties,Usage,Production

Description

4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one is a thiol-reactive, cell-permeant fluorescent probe that easily passes through cell membranes.

Uses

Fluorescent Thiol-Reactive cell permeant probe

Synthesis

638-07-3

108-46-3

25392-41-0

A mixture of resorcinol (1.0 mmol), ethyl 4-chloroacetoacetate (1.5 mmol) and MNESA (0.075 g) was placed in a round-bottomed flask and the reaction was stirred at 90 °C. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction mixture was cooled to room temperature. The catalyst MNESA was separated from the reaction mixture using an external magnetic field. Subsequently, water was added to the reaction mixture and the target product, 4-chloromethyl-7-hydroxychromen-2-one, was extracted with ethyl acetate (EtOAc, 3 × 10 mL). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give the crude product. For further purification, the crude product was recrystallized in ethanol to obtain high purity 4-chloromethyl-7-hydroxychromen-2-one.

References

[1] Tetrahedron Letters, 2005, vol. 46, # 36, p. 6119 - 6121
[2] Journal of Organic Chemistry, 2008, vol. 73, # 1, p. 287 - 290
[3] Synthetic Communications, 2008, vol. 38, # 13, p. 2082 - 2088
[4] Journal of Chemical Research, 2008, # 4, p. 232 - 234
[5] Synthetic Communications, 2010, vol. 40, # 22, p. 3358 - 3364

Excitation / Emission Maximum

348 nm/423 nm

4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE Suppliers

Belgium 1 China 80 Finland 1 Germany 3 India 2 Ukraine 3 United Kingdom 4 United States 9 Global 103

UkrOrgSynthesis Ltd.

Tel: --
Fax: --
Email: y.barysheva@ukrorgsynth.com
Country: Ukraine
ProdList: 6230
Advantage: 38

Enamine

Tel: --
Fax: --
Email: enamine@enamine.net
Country: Ukraine
ProdList: 6216
Advantage: 67

OTAVA chemicals

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Email: north.america@otavachemicals.com
Country: Ukraine
ProdList: 6495
Advantage: 72

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View Lastest Price from 4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one 25392-41-0
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99% min
Supply Ability: 100kg
Release date: 2025-08-18

Career Henan Chemical Co

Product: 4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE 25392-41-0
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-10

25392-41-0, 4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONERelated Search:

4-CHLOROMETHYL-6-HYDROXY-7-METHYL-CHROMEN-2-ONE 8-CHLOROMETHYL-[1,3]DIOXOLO[4,5-G]CHROMEN-6-ONE 4-(CHLOROMETHYL)-6-ETHYL-7-HYDROXY-2H-CHROMEN-2-ONE 6-CHLORO-4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE 4-(chloromethyl)-6,7-dihydroxy-2-benzopyrone 4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE 4-CHLOROMETHYL-6,8-DIFLUOROUMBELLIFERYL-BETA-D-GALACTOPYRANOSIDE 4-CHLOROMETHYL-7-HYDROXY-8-METHYL-CHROMEN-2-ONE 4-(1-CHLOROETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE 4-CHLOROMETHYL-7-METHOXY-CHROMEN-2-ONE AKOS BBS-00001305 4-CHLOROMETHYL-6,8-DIFLUORO-7-ETHOXYCOUMARIN

OTAVA-BB BB7014350028

4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE

4-CHLOROMETHYL-7-HYDROXY-CHROMEN-2-ONE

4-(CHLOROMETHYL)-7-HYDROXYCOUMARIN

AKOS BBS-00000158

CELLTRACKER(TM) BLUE CMHC

BlueCMHC

2H-1-Benzopyran-2-one, 4-(chloroMethyl)-7-hydroxy-

CellHunt Blue CMHC [4-ChloroMethyl-7-hydroxycouMarin]

4-(CHLOROMETHYL)-7-HYDROXY-2H-CHROMEN-2-ONE-2

4-(chloromethyl)-7-hydroxy-2-chromenone

CellHunt Blue CMHC [4-Chloromethyl-7-hydroxycoumarin] [CellTracker Blue CMHC, TM of Molecular Probes]

EOS-61059

AKOS BBS-000001

ViVidFluor Cell Blue CMHC

4-(Chloromethyl)-7-hydroxy-2H-1-benzopyran-2-one

25392-41-0

C10H7O3Cl