ChemicalBook > CAS DataBase List > METHYL 2-BROMOMETHYL-6-NITRO-BENZOATE

METHYL 2-BROMOMETHYL-6-NITRO-BENZOATE

Product Name: METHYL 2-BROMOMETHYL-6-NITRO-BENZOATE
CAS No.: 61940-21-4
Chemical Name: METHYL 2-BROMOMETHYL-6-NITRO-BENZOATE
Synonyms: -6-nitrobenzoate;Lenalidomide Impurity 18;Lenalidomide Impurity 107;METHYL 2-BROMOMETHYL-6-NITRO-BENZOATE;Methyl 2-(bromomethyl)-6-nitrobenzoaite;Methyl 2-(bromomethyl)-6-nitrobenzoate 98%;Methyl 2-(bromomethyl)-6-nitrobenzoate 98%;Methyl 2-(bromomethyl)-6-nitrobenzoate 98%;2-BroMoMethyl-6-nitrobenzoic Acid Methyl Ester;Benzoic acid, 2-(bromomethyl)-6-nitro-, methyl ester
CBNumber: CB6114178
Molecular Formula: C9H8BrNO4
Formula Weight: 274.07
MOL File: 61940-21-4.mol

Less

METHYL 2-BROMOMETHYL-6-NITRO-BENZOATE Property

Melting point:: 84-86°C
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: Light Yellow

Less

Safety

HS Code: 2916310090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

Less

N-Bromosuccinimide Price

TRC

Product number: B685115
Product name: 2-Bromomethyl-6-nitrobenzoicAcidMethylEster
Packaging: 1g
Price: $215
Updated: 2021/12/16

AK Scientific

Product number: Y6595
Product name: 2-(Bromomethyl)-6-nitro-benzoicacidmethylester
Packaging: 100mg
Price: $155
Updated: 2021/12/16

Matrix Scientific

Product number: 119547
Product name: Methyl 2-(bromomethyl)-6-nitrobenzoate
Purity: 95+%
Packaging: 250mg
Price: $308
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 55000
Product name: 2-Bromomethyl-6-nitrobenzoicAcidMethylEster
Packaging: 250mg
Price: $625
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0029864
Product name: BENZOIC ACID, 2-(BROMOMETHYL)-6-NITRO-, METHYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $789.6
Updated: 2021/12/16

Less

METHYL 2-BROMOMETHYL-6-NITRO-BENZOATE Chemical Properties,Usage,Production

Uses

2-Bromomethyl-6-nitrobenzoic Acid Methyl Ester is a potential cyclooxygenase inhibitor derived from thalidomide (T338850), an immunomodulatory agent used primarily in combination with dexamethasone to treat multiple myeloma.

Synthesis

61940-22-5

61940-21-4

Example 2 Preparation of methyl 2-bromomethyl-6-nitrobenzoate: under nitrogen protection, methyl 2-methyl-6-nitrobenzoate (200.0 g, 1.02 moles), 1,3-dibromo-5,5-dimethylacetonitrile (DBH, 162.0 g, 0.57 moles), and methyl acetate (1.20 L) were added to a 3L three-neck flask, and the reaction temperature was maintained at 20 to 25°C. After refluxing the reaction mixture for 0.5-1 h, a solution of 2,2'-azobisisobutyronitrile (AIBN, 8.6 g, 52 mmol) dissolved in 100 mL of methyl acetate was added dropwise over 15-30 min. The reaction was continued at reflux for 6.5-8 hours until the residue of methyl 2-methyl-6-nitrobenzoate was less than 5-10%. Upon completion of the reaction, it was cooled to 15-18 °C and maintained for 50-60 min. The solid was collected by filtration and washed with cold methyl acetate (2 x 100 mL, 5-10 °C) until the amount of methyl 2-bromomethyl-6-nitrobenzoate in the solid was less than 3%. Heptane (1.00 L) was added to the filtrate and the organic phase was subsequently washed with 2% brine (2 x 500 mL) and deionized water (1-2 x 500 mL) until the percentage area of unreacted 5,5-dimethylglycolide urea was less than 0.5% by HPLC detection (210 nm). After removing about 1.80-1.90 L of methyl acetate by concentration under reduced pressure, methyl tert-butyl ether (MTBE, 300 mL) was added. The mixture was refluxed at 65-70 °C for 10-15 min and subsequently cooled to 50-55 °C over 0.5-1 h. 500 mg of methyl 2-bromomethyl-6-nitrobenzoate was added as a crystal seed. The suspension was cooled to 20-25 °C and kept for 2-3 hours. The product was collected by filtration, washed with cold heptane and MTBE (1:2 v/v, 2 x 100 mL, 5-10 °C), and dried at 20-25 °C, 100-120 torr under vacuum to constant weight. Using 200.0 g of methyl 2-methyl-6-nitrobenzoate as raw material, 185.2 g of methyl 2-bromomethyl-6-nitrobenzoate was obtained in 66% yield. The purity of the product was >98% (HPLC area percentage) and the moisture content was <0.1% (Karl Fisher titration).

References

[1] Patent: US2011/251395, 2011, A1. Location in patent: Page/Page column 15
[2] Chemical and Pharmaceutical Bulletin, 2003, vol. 51, # 9, p. 1098 - 1102
[3] Patent: US2011/87033, 2011, A1. Location in patent: Page/Page column 10-11
[4] Patent: WO2015/175773, 2015, A1. Location in patent: Paragraph 0117
[5] Patent: US9272035, 2016, B2. Location in patent: Page/Page column 28-29

METHYL 2-BROMOMETHYL-6-NITRO-BENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

METHYL 2-BROMOMETHYL-6-NITRO-BENZOATE Suppliers

China 83 India 5 United States 8 Global 96

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 7471
Advantage: 65

Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
ProdList: 10266
Advantage: 58

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

Shanghai Sheepchem Co., Ltd.

Tel: +86 (21) 6715-7650
Fax: +86 (21) 6715-7651
Email: sheepchem@163.com
Country: China
ProdList: 994
Advantage: 60

Shanghai Carlow Chemicals Co., Ltd.

Tel: 21-33526724 18930996265
Fax: 37023730
Email: info@carlowchem.com
Country: China
ProdList: 1922
Advantage: 58

Shanghai Leto Pharmatech Co.,Ltd.

Tel: 18016401466
Fax: QQ: 1375988926
Email: sales@letopharm.com
Country: China
ProdList: 245
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Tianjin Anhao Biological Technology Co., Ltd.

Tel
Email: sales@ahpharmatech.com
Country: China
ProdList: 5734
Advantage: 55

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-58362220 0086-15250997978
Fax: 025-58362220
Email: sale@njxizebio.com
Country: China
ProdList: 4855
Advantage: 55

Atop Bio-Tech (Tianjin) Co., Ltd. (Atop)

Tel: 022-66200236 18622210341
Fax: +86-022-66200236
Email: sales@atop-biotech.com
Country: China
ProdList: 295
Advantage: 60

DebyeTec.com Inc.

Tel: 18-086626237 18086626237
Fax: qq:2693528373
Email: 2693528373@qq.com
Country: China
ProdList: 2973
Advantage: 56

Shanghai Kahn Pharmaceutical Co., Ltd.

Tel: 021-34979681; 17701870669
Fax: 021-34979681
Email: 41513101@qq.com
Country: China
ProdList: 1785
Advantage: 55

SuZhou ShiYa Biopharmaceuticals, Inc.

Tel: 0512-0512-52358471 17715136450
Fax: 05125235 6881
Email: sales@shiyabiopharm.com
Country: China
ProdList: 12127
Advantage: 58

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9279
Advantage: 55

BioPharmaMatrix,Inc.

Tel: 0510-86010668
Fax: 0510-86010668
Email: sales@biopharmamatrix.com
Country: China
ProdList: 4739
Advantage: 55

Suzhou JingTong Pharmaceutical Co., Ltd.

Tel: 13675155016
Fax: 18912765016
Email: tongtf110@sina.com
Country: China
ProdList: 963
Advantage: 55

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12475
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-0755-28967200-8062 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9624
Advantage: 60

Chengdu Novel Biomedical Co., Ltd.

Tel: 028-85255396 18302801538
Fax: 028-85255396
Email: cdnovell@163.com
Country: China
ProdList: 2389
Advantage: 58

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

Win-Win Chemical CO., Limited

Tel: 0577-64498589 15325081899
Fax: 0577-56994596
Email: sales@win-winchemical.com
Country: China
ProdList: 1085
Advantage: 58

Jinan Liheng Biotechnology Co., Ltd.

Tel: 0531-18763987518 18763987518
Email: levi@lihengpharm.com
Country: China
ProdList: 1797
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Shanghai zhigan biotechnology co., LTD

Tel
Email: zhiqianbio@126.com
Country: China
ProdList: 19778
Advantage: 58

Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com
Country: China
ProdList: 1615
Advantage: 58

CR Corporation Limited

Tel: +8613062833949
Email: fred.wen@crcorporation.cn
Country: China
ProdList: 8645
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

sgtlifesciences pvt ltd

Tel: +8617013299288
Email: dj@sgtlifesciences.com
Country: China
ProdList: 12373
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Shanxi Xuanran Import and Export Trade Co., Ltd.

Tel: +8617735180244
Email: mike_yan@xuanranglobal.com
Country: CHINA
ProdList: 4017
Advantage: 58

Win-Win chemical CO., Limited

Tel: +86-0086-577-64498589 +86-15355981851
Fax: 0086-577-56994596
Email: sales@win-winchemical.com
Country: China
ProdList: 14359
Advantage: 58

Shanghai Amico Chemicals Co. LTD

Tel: 微信 17321281695 18019252918
Fax: qq:1454668768
Email: 1454668768@qq.com
Country: China
ProdList: 14856
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39927
Advantage: 58

Changzhou Yinghao Technology Development Co., Ltd

Tel: 15151934985
Email: sales@yingsapharm.com
Country: China
ProdList: 5181
Advantage: 58

Shenzhen ruikai de biotechnology co., ltd.

Tel: 0755-61348847 17820674378
Fax: 0755-21016893
Email: 2682116078@qq.com
Country: China
ProdList: 7843
Advantage: 58

Shenzhen Jianyi Biotechnology Co., Ltd

Tel: 0755-84826604
Email: 3001783715@qq.com
Country: CHINA
ProdList: 2896
Advantage: 58

Wuhan kemike Biomedical Technology Co., Ltd

Tel: 027-87747081 18186681184
Email: 1344475572@qq.com
Country: China
ProdList: 7221
Advantage: 58

JW & Y Pharmlab Co., Ltd.

Tel: 021-64340559 13651849907
Fax: 021-64345308
Email: xinyu_shi@jwypharmlab.com.cn
Country: China
ProdList: 9381
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 7986
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Hebei Weite Medical Technology Co., Ltd

Tel: 13180081292 13180081292
Email: contact@wetogethermed.com
Country: China
ProdList: 7949
Advantage: 58

61940-21-4, METHYL 2-BROMOMETHYL-6-NITRO-BENZOATERelated Search:

METHYL 2-BROMOMETHYL-6-NITRO-BENZOATE

Benzoic acid, 2-(bromomethyl)-6-nitro-, methyl ester

2-BroMoMethyl-6-nitrobenzoic Acid Methyl Ester

-6-nitrobenzoate

Lenalidomide Impurity 18

Methyl 2-(bromomethyl)-6-nitrobenzoaite

Methyl 2-(bromomethyl)-6-nitrobenzoate 98%

Lenalidomide Impurity 107

Methyl 2-(bromomethyl)-6-nitrobenzoate 98%

61940-21-4