ChemicalBook > CAS DataBase List > 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
- Product Name
- 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
- CAS No.
- 827026-45-9
- Chemical Name
- 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
- Synonyms
- 3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione;6-Piperidinedione;4-Nitro LenalidoMide;Lenalidomide Impurity B;Lenalidomide Impurities05;Lenalidomide EP Impurity B;Lenalidomide 4-Nitro Impurity;3-(4-Nitro-1-oxo-1, 3-dihydro-isoindol-;3-dihydro-4-nitro-1-oxo-2H-isoindol-2-yl)-;3-(4-Nitro-1-oxoisoindolin-2-yl)piperidin-2,6-dione
- CBNumber
- CB51075415
- Molecular Formula
- C13H11N3O5
- Formula Weight
- 289.24
- MOL File
- 827026-45-9.mol
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3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Property
- Melting point:
- >250°C (dec.)
- Boiling point:
- 616.6±55.0 °C(Predicted)
- Density
- 1.546±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly)
- form
- Solid
- pka
- 10.55±0.40(Predicted)
- color
- Beige to Brown
- InChI
- InChI=1S/C13H11N3O5/c17-11-5-4-10(12(18)14-11)15-6-8-7(13(15)19)2-1-3-9(8)16(20)21/h1-3,10H,4-6H2,(H,14,17,18)
- InChIKey
- JKPJLYIGKKDZDT-UHFFFAOYSA-N
- SMILES
- N1C(=O)CCC(N2CC3=C(C2=O)C=CC=C3[N+]([O-])=O)C1=O
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Safety
- HazardClass
- IRRITANT
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N-Bromosuccinimide Price
TRC
- Product number
- N496395
- Product name
- 4-NitroLenalidomide
- Packaging
- 10mg
- Price
- $205
- Updated
- 2021/12/16
TRC
- Product number
- N496395
- Product name
- 4-NitroLenalidomide
- Packaging
- 100mg
- Price
- $1620
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CHM0079673
- Product name
- 3-(4-NITRO-1-OXO-1,3-DIHYDROISOINDOL-2-YL)PIPERIDINE-2,6-DIONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $2194.5
- Updated
- 2021/12/16
Medical Isotopes, Inc.
- Product number
- 47895
- Product name
- 4-NitroLenalidomide
- Packaging
- 1g
- Price
- $2400
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-M1824
- Product name
- 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
- Purity
- 99.97%
- Packaging
- 10g
- Price
- $561
- Updated
- 2021/12/16
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3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Chemical Properties,Usage,Production
Chemical Properties
White crystalline
Uses
3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione, also known as 4-Nitro Lenalidomide, is a Lenalidomide (L328000) analog. It is an impurity and intermediate of Lenalidomide.
Preparation
3-aminopiperidine-2,6-dione hydrochloride (III) (25 g, 0.15 mol) and dimethyl sulfoxide (150 mL) were charged into 500 mL 3N RBF. Triethylamine (62 g, 0.61 mol) was added slowly to the above reaction mixture under nitrogen over 10 min. Methyl 2-(bromomethyl)-3-nitrobenzoate (II) (45.8 g, 0.16 mol) of example 3 dissolved in dimethyl sulfoxide (50 mL) was added to the reaction mixture under nitrogen over 20 min and heated to 50-55 °C. 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione was obtained by purification.
3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Suppliers
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View Lastest Price from 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione manufacturers
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.
- Product
- 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione 827026-45-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.8%
- Supply Ability
- 9000
- Release date
- 2023-09-07
Henan Aochuang Chemical Co.,Ltd.
- Product
- 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione 827026-45-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-10
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione 827026-45-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
827026-45-9, 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dioneRelated Search:
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