ChemicalBook > CAS DataBase List > 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione

3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione

Product Name: 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
CAS No.: 827026-45-9
Chemical Name: 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
Synonyms: 3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione;6-Piperidinedione;4-Nitro LenalidoMide;Lenalidomide Impurity B;Lenalidomide Impurities05;Lenalidomide EP Impurity B;Lenalidomide 4-Nitro Impurity;3-(4-Nitro-1-oxo-1, 3-dihydro-isoindol-;3-dihydro-4-nitro-1-oxo-2H-isoindol-2-yl)-;3-(4-Nitro-1-oxoisoindolin-2-yl)piperidin-2,6-dione
CBNumber: CB51075415
Molecular Formula: C13H11N3O5
Formula Weight: 289.24
MOL File: 827026-45-9.mol

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3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Property

Melting point:: >250°C (dec.)
Boiling point:: 616.6±55.0 °C(Predicted)
Density: 1.546±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly, Heated), Methanol (Slightly)
form: Solid
pka: 10.55±0.40(Predicted)
color: Beige to Brown
InChI: InChI=1S/C13H11N3O5/c17-11-5-4-10(12(18)14-11)15-6-8-7(13(15)19)2-1-3-9(8)16(20)21/h1-3,10H,4-6H2,(H,14,17,18)
InChIKey: JKPJLYIGKKDZDT-UHFFFAOYSA-N
SMILES: N1C(=O)CCC(N2CC3=C(C2=O)C=CC=C3[N+]([O-])=O)C1=O

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: N496395
Product name: 4-NitroLenalidomide
Packaging: 10mg
Price: $205
Updated: 2021/12/16

TRC

Product number: N496395
Product name: 4-NitroLenalidomide
Packaging: 100mg
Price: $1620
Updated: 2021/12/16

ChemScene

Product number: CS-M1824
Product name: 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
Purity: 99.97%
Packaging: 250mg
Price: $40
Updated: 2021/12/16

AK Scientific

Product number: J55117
Product name: 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
Packaging: 250mg
Price: $48
Updated: 2021/12/16

AK Scientific

Product number: Z3552
Product name: 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
Packaging: 250mg
Price: $66
Updated: 2021/12/16

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3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Chemical Properties,Usage,Production

Chemical Properties

White crystalline

Uses

3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione, also known as 4-Nitro Lenalidomide, is a Lenalidomide (L328000) analog. It is an impurity and intermediate of Lenalidomide.

Preparation

3-aminopiperidine-2,6-dione hydrochloride (III) (25 g, 0.15 mol) and dimethyl sulfoxide (150 mL) were charged into 500 mL 3N RBF. Triethylamine (62 g, 0.61 mol) was added slowly to the above reaction mixture under nitrogen over 10 min. Methyl 2-(bromomethyl)-3-nitrobenzoate (II) (45.8 g, 0.16 mol) of example 3 dissolved in dimethyl sulfoxide (50 mL) was added to the reaction mixture under nitrogen over 20 min and heated to 50-55 °C. 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione was obtained by purification.

3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione manufacturers

Chongqing Chemdad Co., Ltd

Product: 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione 827026-45-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 20tons
Release date: 2025-04-24

Shaanxi Xianhe Biotech Co., Ltd

Product: 3-(4-Nitro-1-oxoisoindolin-2-yl)piperidin-2,6-dione 827026-45-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-17

Henan Aochuang Chemical Co.,Ltd.

Product: 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione 827026-45-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-10

827026-45-9, 3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dioneRelated Search:

3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione

3-(4-Nitro-1-oxoisoindolin-2-yl)piperidin-2,6-dione

4-Nitro LenalidoMide

3-dihydro-4-nitro-1-oxo-2H-isoindol-2-yl)-

6-Piperidinedione

3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione

3-(4-nitro-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione

3-(1,3-Dihydro-4-nitro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione

3-(4-Nitro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione

(3S)-3-(4-Nitro-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione

2,6-Piperidinedione, 3-(1,3-dihydro-4-nitro-1-oxo-2H-isoindol-2-yl)-

Lenalidomide EP Impurity B

Lenalidomide 4-Nitro Impurity

3-(1-keto-4-nitro-isoindolin-2-yl)piperidine-2,6-quinone

3-(4-nitro-1-oxo-2-isoindolinyl)piperidine-2,6-dione

3-(7-nitro-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione

Lenalidomide Impurity B

3-(4-Nitro-1-oxo-1, 3-dihydro-isoindol-

3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2

3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dio...

Lenalidomide Impurities05

Lenalidomide Impurity BQ: What is Lenalidomide Impurity B Q: What is the CAS Number of Lenalidomide Impurity B Q: What is the storage condition of Lenalidomide Impurity B

3-(4-Nitro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione (4-Nitro Analogue of Lenalidomide)

3-（4′-Nitroisondoline-1′-One）-1-Piperidine-2,6-Dione

3-(1-Oxo-4-nitro-1,3-Dihydro-isoindole-2-yl)piperidine-2,6-dione

3- (4-nitro-1-oxo-1,3-dihydroisoindole-2-yl) piperidine-2,6-dione

827026-45-9

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