Amoscanate

Product Name: Amoscanate
CAS No.: 26328-53-0
Chemical Name: Amoscanate
Synonyms: GO 9333;CGP-4540;C-9333 GO;CCRIS 4111;CIBA-9333 GO;Nithiocyamine;amoscanate USP/EP/BP;N-(4-isothiocyanatophenyl)-4-nitroaniline;4-Nitro-4'-iso-thiocyanate diphenyl amine;4-Isothiocyanato-N-(4-nitrophenyl)-aniline
CBNumber: CB61178018
Molecular Formula: C13H9N3O2S
Formula Weight: 271.29
MOL File: 26328-53-0.mol

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Amoscanate Property

Melting point:: 196-198°
Boiling point:: 469.7±30.0 °C(Predicted)
Density: 1.3474 (rough estimate)
refractive index: 1.6740 (estimate)
pka: -3.50±0.40(Predicted)
form: Solid
color: Crystals from acetone

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Safety

Toxicity: dnr-esc 1 g/L MUREAV 164,9,86

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0010703
Product name: AMOSCANATE
Purity: 95.00%
Packaging: 5MG
Price: $498.81
Updated: 2021/12/16

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Amoscanate Chemical Properties,Usage,Production

Chemical Properties

Orange-yellow crystalline powder, odorless and tasteless. Melting point 196-198°C. Insoluble in water, slightly soluble in acetone, chloroform, benzene and ethanol.

Uses

Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma[1].

Definition

ChEBI: Amoscanate is an isothiocyanate that is phenyl isothiocyanate in which the hydrogen at the para- position has been replaced by a 4-nitroanilinyl group. It has a role as a schistosomicide drug. It is a C-nitro compound, an isothiocyanate and a secondary amino compound. It is functionally related to a diphenylamine.

Safety Profile

Mutation data reported. Ananthelmintic agent.

in vivo

Amoscanate (500 mg/kg; p.o.; 10 days) destructs ependyma and periventricular brain^[1].
Amoscanate (250 and 500 mg/kg; p.o.; 28 days) elicits necrosis, Ca⁺⁺-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum^[1].
Amoscanate (25~500 mg/kg; p.o.; 20 days) elicits progressive necrosis of ependyma^[1].
Amoscanate elicits massive ultrastructural damage in ependymal cells^[1].

Animal Model:	Sprague-Dawley rats^[1]
Dosage:	500 mg/kg
Administration:	P.o.; 10 days
Result:	Destructed ependyma and periventricular brain.

Animal Model:	Sprague-Dawley rats^[1]
Dosage:	250 and 500 mg/kg
Administration:	P.o.; 28 days
Result:	Elicited necrosis, Ca⁺⁺-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum.

Animal Model:	Sprague-Dawley rats^[1]
Dosage:	25~500 mg/kg
Administration:	P.o.; 20 days
Result:	Elicited progressive necrosis of ependymal.

IC 50

Schistosome

References

[1] Johanson C, et al. The distributional nexus of choroid plexus to cerebrospinal fluid, ependyma and brain: toxicologic/pathologic phenomena, periventricular destabilization, and lesion spread. Toxicol Pathol. 2011;39(1):186-212. DOI:10.1177/0192623310394214

Amoscanate Preparation Products And Raw materials

Raw materials

P-nitrofluorobenzene 2-CHLORO-5-NITROBENZENESULFONIC ACID Thiophosgene 4-Nitrodiphenylamine 4-NITROBENZENESULFONIC ACID p-Phenylenediamine

Preparation Products

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Amoscanate Suppliers

China 21 United States 2 Global 23

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 20284
Advantage: 58

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 7938
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62220
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Hubei Wanye Zhongcheng Chemical Reagent Co., Ltd.

Tel: 18671296875
Email: 1205035102@qq.com
Country: China
ProdList: 4302
Advantage: 58

Xianning Shen Lan Biomedical Research and Development Co., Ltd.

Tel: 18171815831
Email: 1341138380@qq.com
Country: China
ProdList: 4310
Advantage: 58

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View Lastest Price from Amoscanate manufacturers

Qingdao RENAS Polymer Material Co., Ltd.

Product: N-(4-isothiocyanatophenyl)-4-nitroaniline 26328-53-0
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2025-05-12

Dideu Industries Group Limited

Product: Amoscanate 26328-53-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-06-18

26328-53-0, AmoscanateRelated Search:

Amoscanate

4-Isothiocyanato-N-(4-nitrophenyl)benzenamine

C-9333 GO

CGP-4540

CIBA-9333 GO

Nithiocyamine

4-Nitro-4'-iso-thiocyanate diphenyl amine

Benzenamine, 4-isothiocyanato-N-(4-nitrophenyl)-

amoscanate USP/EP/BP

CCRIS 4111

GO 9333

N-(4-isothiocyanatophenyl)-4-nitroaniline

4-Isothiocyanato-N-(4-nitrophenyl)-aniline

26328-53-0