Spiromustine
- Product Name
- Spiromustine
- CAS No.
- 56605-16-4
- Chemical Name
- Spiromustine
- Synonyms
- SHM;NCI172112;NSC268497;NSC-172112;Spiromustine;Spiromustard;NCI172112,NCI-172112;spirohydantoin mustard;Spirohydantoin masturd;Spiromustine USP/EP/BP
- CBNumber
- CB61179772
- Molecular Formula
- C14H23Cl2N3O2
- Formula Weight
- 336.26
- MOL File
- 56605-16-4.mol
Spiromustine Property
- Melting point:
- 125.5°C
- Density
- 1.3876 (rough estimate)
- refractive index
- 1.6070 (estimate)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 10.53±0.20(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- API0012356
- Product name
- PROSPIDIUM
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.49
- Updated
- 2021/12/16
Spiromustine Chemical Properties,Usage,Production
Uses
Antineoplastic.
in vivo
NCI172112 (Spirohydantoin mustard, SHM) might serve as a carrier to cross the blood brain barrier[1]. The cumulative excretion of radioactivity in the urine and faeces of rats after administration of [2-chloroethyl-U-14C]NCI172112 or [hydantoin-4-14C]NCI172112 ( 3.13 mg/kg. i.v.) is measured. Four hours after dosing, a significantly (P<0.005) greater amount of radioactivity has been excreted in the urine of rats treated with [hydantoin-14C]NCI172112 than with [ethyl-14C]NCI172112. However, by 24 h, approx.50% of dose is recovered in the urine with both labelled materials. Clearance of radioactivity in the faeces is slow, but, as for the renal excretion, is significantly greater for the hydantoin-14C moiety. No radioactivity is found in the expired air of a rat receiving a single dosing of [hydantoin-14C]NCI172112 and less than 1% is measured after administration of [ethyl-14C]NCI172112. Renal clearance of radioactivity is similar 4 h after administration of [14C]NCI172112 to rats with biliary cannulas, with 14.1±2.9 and 17.5±2.1% of the ethyl-14C and 34.5±2.5 and 33.1±6.3%, of the hydantoin-14C dose appearing in the urine after dosing with 3.13 and 6.25 mg/kg, respectively. A difference in the 4 h urinary excretion of the two labels also is observed in dogs given [14C]NCI172112 (1 mg/kg, i.v.). The percentages of hydantoin-14C and ethyl-14C eliminated are 29.4±2.7% and 17.2±3.5%, respectively (P<0.05)[2].
Spiromustine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Spiromustine manufacturers
- Product
- Spiromustine 56605-16-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-05