ChemicalBook > CAS DataBase List > KAHWEOL

KAHWEOL

Product Name
KAHWEOL
CAS No.
6894-43-5
Chemical Name
KAHWEOL
Synonyms
KAHWEOL;Kahweol-RM;KAHWEOL USP/EP/BP;Kahweol, 10 mM in DMSO;Kahweol DISCONTINUED, unstable;Kahweol, Diterpene molecule in coffee beans;(3bS)-3b,4,5,6,7,8,9,10,10aα,10b-Decahydro-7β-hydroxy-10bβ-methyl-5aβ,8β-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol;5a,8-Methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol,3b,4,5,6,7,8,9,10,10a,10b-decahydro-7-hydroxy-10b-methyl-,(3bS,5aS,7R,8R,10aR,10bS)-;[3bS-(3balpha,5abeta,7beta,8beta,10aalpha,10bbeta)]-3b,4,5,6,7,8,9,10,10a,10b-Decahydro-7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol
CBNumber
CB6117982
Molecular Formula
C20H26O3
Formula Weight
314.42
MOL File
6894-43-5.mol
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KAHWEOL Property

Melting point:
88-90℃
Boiling point:
476.6±45.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMF:5.0(Max Conc. mg/mL);0.64(Max Conc. mM)
DMSO:18.17(Max Conc. mg/mL);57.77(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);0.64(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:5):0.02(Max Conc. mg/mL);0.06(Max Conc. mM)
pka
14.43±0.40(Predicted)
form 
White to off-white solid.
color 
Off-white to light yellow
LogP
3.380 (est)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL82293
Product name
Kahweol
Purity
phyproof<SUP>&#174;</SUP> Reference Substance
Packaging
20 mg
Price
$271
Updated
2025/07/31
Cayman Chemical
Product number
14015
Product name
Kahweol
Purity
≥98%
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
14015
Product name
Kahweol
Purity
≥98%
Packaging
10mg
Price
$135
Updated
2024/03/01
Cayman Chemical
Product number
14015
Product name
Kahweol
Purity
≥98%
Packaging
25mg
Price
$315
Updated
2024/03/01
Biorbyt Ltd
Product number
orb594400
Product name
Kahweol
Packaging
20mg
Price
$391
Updated
2021/12/16
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KAHWEOL Chemical Properties,Usage,Production

Uses

Kahweol is an antioxidant diterpene contained in unfiltered coffee. Kahweol behaves as an anti-inflammatory and anti-angiogenic compound with potential use in antitumoral therapies. Recent research have demonstrated the ability of Kahweol in inhibiting metastasis by modulating expressions of MMPs and VEGF via STAT3 inactivation.

Definition

ChEBI: Kahweol is a diterpenoid with formula C20H26O3, isolated from the beans of Coffea arabica. It exhibits antioxidant, anti-inflammatory, anti-angiogenesis and anti-proliferative properties. It has a role as an angiogenesis inhibitor, an apoptosis inducer, an antioxidant, an anti-inflammatory agent, an antineoplastic agent and a plant metabolite. It is a diterpenoid, a member of furans, an organic heteropentacyclic compound, a tertiary alcohol and a primary alcohol.

KAHWEOL Preparation Products And Raw materials

Raw materials

Preparation Products

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6894-43-5, KAHWEOLRelated Search:


  • 5a,8-Methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol,3b,4,5,6,7,8,9,10,10a,10b-decahydro-7-hydroxy-10b-methyl-,(3bS,5aS,7R,8R,10aR,10bS)-
  • KAHWEOL
  • (3bS)-3b,4,5,6,7,8,9,10,10aα,10b-Decahydro-7β-hydroxy-10bβ-methyl-5aβ,8β-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol
  • [3bS-(3balpha,5abeta,7beta,8beta,10aalpha,10bbeta)]-3b,4,5,6,7,8,9,10,10a,10b-Decahydro-7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol
  • KAHWEOL USP/EP/BP
  • Kahweol DISCONTINUED, unstable
  • Kahweol-RM
  • Kahweol, Diterpene molecule in coffee beans
  • Kahweol, 10 mM in DMSO
  • 6894-43-5
  • 6984-43-5
  • Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals