Zetidoline
- Product Name
- Zetidoline
- CAS No.
- 51940-78-4
- Chemical Name
- Zetidoline
- Synonyms
- MDL-308;Zetidoline;1-(3-Chlorophenyl)-3-[2-(3,3-dimethylazetidin-1-yl)ethyl]-2-imidazolidinone;2-Imidazolidinone, 1-(3-chlorophenyl)-3-[2-(3,3-dimethyl-1-azetidinyl)ethyl]-
- CBNumber
- CB61180095
- Molecular Formula
- C16H22ClN3O
- Formula Weight
- 307.823
- MOL File
- 51940-78-4.mol
N-Bromosuccinimide Price
- Product number
- API0012818
- Product name
- ZETIDOLINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.34
- Updated
- 2021/12/16
Zetidoline Chemical Properties,Usage,Production
Originator
MDL 308 ,Dow Chemical
Manufacturing Process
A solution of 5.0 g of 1-(m-chlorophenyl)-2-imidazolidinone in 30 ml of dimethylformamide is added at room temperature to a mixture of 1.5 g of 50% NaH (mineral oil emulsion) in 30 ml of dimethylformamide. The reaction mixture is stirred for 1 h at room temperature and then 4.5 g of 3,3-dimethyl- 1-(2-chloroethyl)azetidine are added. The mixture is stirred again at room temperature for 2 h and then it is heated for 5 h at 80°-85°C. The salts are filtered off and the solvent is removed under vacuum. The residue is taken up with 8 ml of 18% HCl and 16 ml of water and extracted with diethyl ether. The water solution is alkalinized by addition of 15% sodium carbonate and then extracted with diethyl ether. By evaporation of the organic layer a residue is obtained that is triturated in light petroleum. Yield of 1-(m- chlorophenyl)-3-[2-(3,3-dimethylazetidin-1-y1)ethyl]-2-imidazolidinone 7.25 g, melting point 84°-85°C (after recrystallization from hexane).
Therapeutic Function
Antipsychotic, Neuroleptic
Zetidoline Preparation Products And Raw materials
Raw materials
Preparation Products
Zetidoline Suppliers
- Tel
- 18096409024
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- Country
- China
- ProdList
- 1953
- Advantage
- 58
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- +1-781-999-5354
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- Country
- United States
- ProdList
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