5-Hydroxytryptamine

ChemicalBook > CAS DataBase List > 5-Hydroxytryptamine

5-Hydroxytryptamine

Product Name: 5-Hydroxytryptamine
CAS No.: 50-67-9
Chemical Name: 5-Hydroxytryptamine
Synonyms: serotonin;serotonine;3-(2-aminoethyl)-1H-indol-5-ol hydrochloride;enteramine;SEROTONIN BASE;5-Hydroxytryptamine,freebase;5-hta;antemoqua;antemovis;substanzds
CBNumber: CB6119335
Molecular Formula: C10H12N2O
Formula Weight: 176.22
MOL File: 50-67-9.mol

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5-Hydroxytryptamine Property

Melting point:: 167.5 °C
Boiling point:: 307.83°C (rough estimate)
Density: 1.1102 (rough estimate)
refractive index: 1.7110 (estimate)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 9.8(at 25℃)
form: Solid
color: White to off-white
BRN: 143524
Stability:: Hygroscopic
CAS DataBase Reference: 50-67-9(CAS DataBase Reference)
EPA Substance Registry System: Serotonin (50-67-9)

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Safety

Hazard Codes: T
Risk Statements: 63-25
Safety Statements: 36/37-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 14927
Product name: Serotonin
Purity: analytical standard
Packaging: 25mg
Price: $121
Updated: 2024/03/01

TRC

Product number: H977043
Product name: Serotonin
Packaging: 100mg
Price: $145
Updated: 2021/12/16

Usbiological

Product number: S1001-01
Product name: Serotonin
Packaging: 50ul
Price: $415
Updated: 2021/12/16

Usbiological

Product number: S1001
Product name: Serotonin
Packaging: 500ul
Price: $1044
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0006544
Product name: 5-HT
Purity: 95.00%
Packaging: 10G
Price: $2008.78
Updated: 2021/12/16

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5-Hydroxytryptamine Chemical Properties,Usage,Production

Description

Serotonin is the baby boomer of neurotransmitters: It was identified in the late 1940s, its adolescence was troubled and turbulent, it made the drug scene in the 1960s, and it nearly died of an overdose in the early 1970s. At one point, the remark was made that serotonin doesn't do anything. On reaching its middle years, serotonin has matured and become an important topic of study, a household name, and more complicated than ever. Serotonin has been associated with, among other things, anxiety, depression, schizophrenia, drug abuse, sleep, dreaming, hallucinogenic activity, headache, cardiovascular disorders, and appetite control, and it is now dabbling in acupuncture and transcendental meditation.
Serotonin was independently identified in the late 1940s by two groups of investigators: In the United States, it was called serotonin, whereas in Italy, it was called enteramine. Its total synthesis in the early 1950s confirmed that both substances were 5-hydroxytryptamine (5-HT ). Serotonin (5-HT ) was detected in numerous plant and animal species and, in the mid-1950s, was identified in the central nervous system (CNS) of animals. A neurotransmitter role was subsequently proposed for this substance. Later, 5-HT was implicated in a variety of central and peripheral physiologic actions. It seemed to be involved in vasoconstriction and vasodilation, regulation of body temperature, sleep, and hormonal regulation, and evidence suggested that it might be involved in depression. The structural similarity between 5-HT and the then recently discovered hallucinogenic agent (+)-lysergic acid diethylamide (LSD) intrigued investigators. This observation led to speculation that 5-HT might be involved in the mechanism of action of psychoactive substances and that it might play a seminal role in various mental disorders.

Uses

neurotransmitter

Definition

ChEBI: A primary amino compound that is the 5-hydroxy derivative of tryptamine.

Biological Functions

Serotonin (5-hydroxytryptamine, or 5HT) is present in the brain as well as in the periphery. In humans, about 90% of the total serotonin in the body is in enterochromaffin cells in the gastrointestinal tract; the remaining 10% occurs primarily in the platelets and brain. The physiological significance of the vast amounts of serotonin constantly synthesized and metabolized in the periphery still remains an enigma. Brain serotonin has been implicated as a potential neurotransmitter in the mediation of a wide variety of phenomena.

Clinical Use

Initially, serotonin was thought to be a sleep-promoting neurotransmitter or an “antiwaking” agent. The recognition of the numerous 5-HT receptor subtypes, often with unique anatomical distribution, has required that a more complex role for serotonin be developed. Current studies indicate that conditions for sleep are now met when the serotoninergic system becomes inactive. The serotonin agonists for the 5-HT1 (via the 5-HT1A and 5-HT1B types at the hypothalamic level), 5-HT2, and 5-HT3 receptors cause wakefulness and inhibit sleep. Blockade of the 5-HT2 receptors (e.g., the 5-HT2 antagonist ritanserin) results in increased NREM sleep and inhibition of REM sleep. It has been proposed that the 5-HT1A and 5- HT2 may be involved in sleep by regulation of sleep-promoting substances in the hypothalamus. With the development of newer and more selective ligands for use in studying the numerous serotonin receptor subtypes, a better understanding of the role of serotonin in sleep will evolve.

Metabolism

The major route of metabolism for 5-HT is oxidative deamination by monoamine oxidase (MAO-A) to the unstable 5-hydroxyindole- 3-acetaldehyde, which is either reduced to 5-hydroxytryptophol (~15%) or oxidized to 5-hydroxyindole-3-acetic acid (~85%). In the pineal gland, 5-HT is acetylated by 5-HT N-acetyltransferase to N-acetylserotonin, which undergoes O-methylation by 5-hydroxyindole-O-methyltransferase to melatonin.

References

Petrova, Men'shikov,J. Gen. Chern. USSR, 31,2413 (1961)

5-Hydroxytryptamine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Hydroxytryptamine manufacturers

Wuhan Xinhao Biotechnology Co., Ltd

Product: 3-(2-aminoethyl)indol-5-ol 50-67-9
Price: US $10.00-100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 Metric Ton/Month
Release date: 2024-01-17

Lihe Pharm Technology（Wuhan）Co.,Ltd

Product: 5-Hydroxytryptamine 50-67-9
Price: US $60.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100MT
Release date: 2023-08-23

Hebei Fengqiang Trading Co., LTD

Product: 5-Hydroxytryptamine 50-67-9
Price: US $100.00/bag
Min. Order: 1bag
Purity: 99
Supply Ability: 5000
Release date: 2023-09-11

50-67-9, 5-HydroxytryptamineRelated Search:

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5-Hydroxytryptamine,freebase

3-(2-AMINOETHYL)-5-HYDROXYINDOLE(SEROTONIN)

5-HYDROXYTRYPTAMINE 98%

3-(2-aminoethyl)-1H-indol-5-ol hydrochloride

3-(2-Aminoethyl)-5-oxyindole

3-(2-azanylethyl)-1H-indol-5-ol

3-(2-AMINOETHYL)INDOL-5-OL

3-(2-AMINOETHYL)-5-HYDROXYINDOLE

3-(2-AMINO-ETHYL)-1H-INDOL-5-OL

5-HYDROXYTRYPTAMINE

AURORA KA-7815

3-(2-aminoethyl)-indol-5-o

3-(beta-aminoethyl)-5-hydroxyindole

5-hta

5-hydroxy-3-(beta-aminoethyl)indole

substanceds

substanzds

thrombotonin

SEROTONIN BASE

1H-Indol-5-ol, 3-(2-aMinoethyl)-

antemoqua

antemovis

dssubstance

enteramine

hippophain

serotonin

serotonine

2-(5-hydroxy-1H-indol-3-yl)ethylammonium

Serotonin Creatinine Sulfate Complex (5-Hydroxytryptamine) (Solution)

MELATONINE EP IMP A

Rabbit Anti-5-HT antibody

Melatonin?EP?Impurity?A

50-67-9

HOC8H5NCD2CD2NH2稨Cl

Standards - 13C & 2H for GC-Mass Spectrometry

Tryptamines