1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE

Product Name: 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE
CAS No.: 24310-36-9
Chemical Name: 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE
Synonyms: 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROB;1,2,3,4-tetrahydro-1-tosylbenzo[b]azepin-5-one;1-Tosyl-2,3-dihydro-1H-1-benzazepine-5(4H)-one;1-Tosyl-2,3,4,5-tetrahydro-1H-1-benzazepine-5-one;1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one;1-(4-methylphenyl)sulfonyl-3,4-dihydro-2H-1-benzazepin-5-one;1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE;1,2,3,4-tetrahydro-1-(4-methylbenzenesulfonyl)-1-benzazepin-...;1,2,3,4-tetrahydro-1-(4-Methylbenzenesulfonyl)-1-benzazepin-5-one;1-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
CBNumber: CB6119799
Molecular Formula: C17H17NO3S
Formula Weight: 315.39
MOL File: 24310-36-9.mol

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1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE Property

Melting point:: 126 °C(Solv: methanol (67-56-1))
Boiling point:: 489.7±48.0 °C(Predicted)
Density: 1.286±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -3?+-.0.20(Predicted)

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R238716
Product name: 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDRO-BENZO(B)AZEPIN-5-ONE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $30.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: R238716
Product name: 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDRO-BENZO(B)AZEPIN-5-ONE
Purity: Aldrich
Packaging: 25mg
Price: $29.8
Updated: 2024/03/01

TRC

Product number: T295965
Product name: 1,2,3,4-Tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one
Packaging: 25mg
Price: $55
Updated: 2021/12/16

BroadPharm

Product number: BP-30012
Product name: 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE
Purity: 98%
Packaging: 500mg
Price: $120
Updated: 2021/12/16

Matrix Scientific

Product number: 055451
Product name: 1-[(4-Methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
Purity: 95+%
Packaging: 1g
Price: $142
Updated: 2021/12/16

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1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE Chemical Properties,Usage,Production

Uses

1,2,3,4-Tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one is an intermediate used to prepare nonpeptide vasopressin V2 receptor antagonist tetrahydro-1H-benzazepines. It is also used to synthesize 4''-[(4,4-difluoro-5-methylidene-2,3,4,5-tetrahydro-1H-1-benzoazepin-1-yl)carbonyl]-2-phenylbenzanilide derivatives as non-peptide arginine vasopressin antagonists for both V1A and V2 receptors.

Synthesis

1127-74-8

98-59-9

24310-36-9

To a stirred solution of 1,2,3,4-tetrahydrobenzo[b]azepin-5-one (50 g, 0.31 mol) in dichloromethane (DCM, 250 mL) was added pyridine (175 mL). The reaction mixture was cooled in an ice bath, followed by the slow addition of p-toluenesulfonyl chloride (TsCl, 84 g, 0.44 mol). When the addition was complete, the mixture was gradually warmed to room temperature and stirred continuously overnight. Upon completion of the reaction, the mixture was diluted with water (750 mL) and subsequently extracted with dichloromethane (300 mL x 3). The organic phases were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to remove the solvent. The resulting residue was washed with mixed solvents (petroleum ether/ethyl acetate = 70:1) to afford the target product 1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one as a light yellow solid (97 g, 99% yield). eSI MS m/z = 316.05 [M + H]+.

References

[1] Patent: WO2017/123884, 2017, A1. Location in patent: Page/Page column 92
[2] Heterocycles, 2000, vol. 52, # 1, p. 81 - 84
[3] Patent: WO2005/37796, 2005, A1. Location in patent: Page/Page column 160
[4] Patent: US2015/291533, 2015, A1. Location in patent: Paragraph 0137-0139

1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE Suppliers

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View Lastest Price from 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE manufacturers

Career Henan Chemical Co

Product: 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE 24310-36-9
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-04

24310-36-9, 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONERelated Search:

N-(2-FORMYLPHENYL)-4-METHYL-BENZENESULF& 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one 1,2,3,4-TETRAHYDRO-4-(HYDROXYMETHYLENE)-1-[(4-METHYLPHENYL)SULFONYL]-5H-1-BENZAZEPIN-5-ONE 2,3,4,5-Tetrahydro-1H-benzo[b]azepine 4-BROMO-1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE

1,2,3,4-Tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one

1-Tosyl-2,3,4,5-tetrahydro-1H-1-benzazepine-5-one

1-Tosyl-2,3-dihydro-1H-1-benzazepine-5(4H)-one

1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE

1-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

1-[(4-Methylbenzene)sulfonyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one

1,2,3,4-tetrahydro-1-tosylbenzo[b]azepin-5-one

1,2,3,4-tetrahydro-1-(4-Methylbenzenesulfonyl)-1-benzazepin-5-one

1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

5H-1-Benzazepin-5-one, 1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-

1-(4-methylphenyl)sulfonyl-3,4-dihydro-2H-1-benzazepin-5-one

1,2,3,4-tetrahydro-1-(4-methylbenzenesulfonyl)-1-benzazepin-...

1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROB

24310-36-9

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