ChemicalBook > CAS DataBase List > 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE

1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE

Product Name: 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE
CAS No.: 24310-36-9
Chemical Name: 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE
Synonyms: 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROB;1,2,3,4-tetrahydro-1-tosylbenzo[b]azepin-5-one;1-Tosyl-2,3-dihydro-1H-1-benzazepine-5(4H)-one;1-Tosyl-2,3,4,5-tetrahydro-1H-1-benzazepine-5-one;1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one;1-(4-methylphenyl)sulfonyl-3,4-dihydro-2H-1-benzazepin-5-one;1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE;1,2,3,4-tetrahydro-1-(4-methylbenzenesulfonyl)-1-benzazepin-...;1,2,3,4-tetrahydro-1-(4-Methylbenzenesulfonyl)-1-benzazepin-5-one;1-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
CBNumber: CB6119799
Molecular Formula: C17H17NO3S
Formula Weight: 315.39
MOL File: 24310-36-9.mol

Less

1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE Property

Melting point:: 126 °C(Solv: methanol (67-56-1))
Boiling point:: 489.7±48.0 °C(Predicted)
Density: 1.286±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -3?+-.0.20(Predicted)

Less

Safety

HazardClass: IRRITANT

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R238716
Product name: 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDRO-BENZO(B)AZEPIN-5-ONE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $30.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: R238716
Product name: 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDRO-BENZO(B)AZEPIN-5-ONE
Purity: Aldrich
Packaging: 25mg
Price: $29.8
Updated: 2024/03/01

TRC

Product number: T295965
Product name: 1,2,3,4-Tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one
Packaging: 25mg
Price: $55
Updated: 2021/12/16

BroadPharm

Product number: BP-30012
Product name: 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE
Purity: 98%
Packaging: 500mg
Price: $120
Updated: 2021/12/16

Matrix Scientific

Product number: 055451
Product name: 1-[(4-Methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
Purity: 95+%
Packaging: 1g
Price: $142
Updated: 2021/12/16

Less

1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE Chemical Properties,Usage,Production

Uses

1,2,3,4-Tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one is an intermediate used to prepare nonpeptide vasopressin V2 receptor antagonist tetrahydro-1H-benzazepines. It is also used to synthesize 4''-[(4,4-difluoro-5-methylidene-2,3,4,5-tetrahydro-1H-1-benzoazepin-1-yl)carbonyl]-2-phenylbenzanilide derivatives as non-peptide arginine vasopressin antagonists for both V1A and V2 receptors.

Synthesis

1127-74-8

98-59-9

24310-36-9

To a stirred solution of 1,2,3,4-tetrahydrobenzo[b]azepin-5-one (50 g, 0.31 mol) in dichloromethane (DCM, 250 mL) was added pyridine (175 mL). The reaction mixture was cooled in an ice bath, followed by the slow addition of p-toluenesulfonyl chloride (TsCl, 84 g, 0.44 mol). When the addition was complete, the mixture was gradually warmed to room temperature and stirred continuously overnight. Upon completion of the reaction, the mixture was diluted with water (750 mL) and subsequently extracted with dichloromethane (300 mL x 3). The organic phases were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to remove the solvent. The resulting residue was washed with mixed solvents (petroleum ether/ethyl acetate = 70:1) to afford the target product 1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydrobenzo[b]azepin-5-one as a light yellow solid (97 g, 99% yield). eSI MS m/z = 316.05 [M + H]+.

References

[1] Patent: WO2017/123884, 2017, A1. Location in patent: Page/Page column 92
[2] Heterocycles, 2000, vol. 52, # 1, p. 81 - 84
[3] Patent: WO2005/37796, 2005, A1. Location in patent: Page/Page column 160
[4] Patent: US2015/291533, 2015, A1. Location in patent: Paragraph 0137-0139

1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE Suppliers

China 60 France 1 India 2 United Kingdom 3 United States 12 Global 78

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527621225
Email: 1791901229@qq.com
Country: China
ProdList: 6945
Advantage: 52

Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
Country: China
ProdList: 4267
Advantage: 65

Suzhou Sibian Chemical Technology Co.,Ltd.

Tel: 0512-65617459 18915409046
Fax: 0512-65617459
Email: sales@sibian-chem.com
Country: China
ProdList: 1922
Advantage: 55

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

China Nobel Chem Co., Limited

Tel: +86(0)21 60484900
Fax: +86(0)21 60484900
Country: China
ProdList: 764
Advantage: 50

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-86818997 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2965
Advantage: 60

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Nanjing Chalf-Pharm Technology Co., Ltd.

Tel: 025-57018978 18251899859
Fax: 025-57018008
Email: sales@chalf-pharm.com
Country: China
ProdList: 5674
Advantage: 50

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9858
Advantage: 58

Nanjing Vital Chemical Co., Ltd.

Tel: 025-87193546 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 9021
Advantage: 60

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Hubei Hongxin Ruiyu Fine Chemical Co., Ltd.

Tel: 027-027-65526929 15102793023
Fax: 027-65526669
Email: hbhxry@foxmail.com
Country: China
ProdList: 1786
Advantage: 55

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: (5)02557626880
Email: dt3@aikonchem.com
Country: China
ProdList: 15493
Advantage: 58

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-51831887 15337167856
Fax: 027-51837635 QQ1165326703
Email: hubeixinyuanshun@163.com
Country: China
ProdList: 10295
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-037163312495,13303845143 13303845143
Fax: QQ3001379618
Email: 3001379618@qq.com
Country: China
ProdList: 10267
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Labnetwork lnc.

Tel: +86-27-50766799 +8618062016861
Email: contact@labnetwork.com
Country: China
ProdList: 19987
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Nanjing Boomking Industry Co., Ltd

Tel: 15298391928
Email: cherry_kingstone@163.com
Country: China
ProdList: 823
Advantage: 58

Hubei xin bonus chemical co. LTD

Tel: 86-13657291602
Fax: 027-59338440
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 22963
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39927
Advantage: 58

Shanghai Boyi Biomedical Technology Co., Ltd.

Tel: 021-021-54331997 18321536537
Email: info@ansionpharma.com
Country: China
ProdList: 2336
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Neostar United (Changzhou) Industrial Co., Ltd.

Tel: +86-0519-85551759 +8613506123987
Fax: +0086-519-85557389
Email: marketing1@neostarunited.com
Country: China
ProdList: 8830
Advantage: 58

Shanghai Botuo Biotechnology Co., LTD

Tel: 16621358918
Fax: QQ:402135374
Email: botuopharma888@163.com
Country: China
ProdList: 9208
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39665
Advantage: 58

Shanghai klamar Reagent Co., LTD

Tel: 4001650900 13817534909
Email: 3003940895@qq.com
Country: China
ProdList: 10714
Advantage: 58

Shanghai Lingfu Pharmaceutical Research Co. LTD

Tel: +86(21)5895 0110 19945755304
Email: sales@chemany.com
Country: China
ProdList: 9984
Advantage: 58

Aobolihui

Tel: 0917-18691729 18691729963
Email: 2553382659@qq.com
Country: China
ProdList: 4739
Advantage: 58

Shanghai Haohong Scientific Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Wuhan Fengyao Tonghui Chemical Products Co. LTD

Tel: 027-87466205 15377579727
Email: 1228964013@qq.com
Country: China
ProdList: 8558
Advantage: 58

Shaanxi Didu New Material Co., Ltd

Tel: 029-81145920 17391631969
Email: 1046@dideu.com
Country: China
ProdList: 9996
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50751
Advantage: 58

Suzhou Haiben Pharmaceutical Co., Ltd

Tel: 19353112242
Email: 1816280386@qq.com
Country: China
ProdList: 8045
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29995
Advantage: 58

Hubei Soren Technology Co., Ltd

Tel: 13419562052 13419562052
Email: wwmlyb@163.com
Country: China
ProdList: 3932
Advantage: 58

Young&Lively Pharminblock Co,.Ltd.

Tel: 18600731423
Email: jason_gao@yl-pharminblock.com
Country: China
ProdList: 1952
Advantage: 58

Beijing Born Pharmaceutical Co., Ltd.

Tel: 13261021908
Email: 1198872622@qq.com
Country: China
ProdList: 909
Advantage: 55

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Henan Tianfu Chemical Co.,Ltd.

Tel: +86-0371-55170693 +86-19937530512
Fax: 0371-55170693
Email: info@tianfuchem.com
Country: China
ProdList: 21612
Advantage: 55

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Email: sales@coreychem.com
Country: China
ProdList: 29846
Advantage: 58

SUZHOU SENFEIDA CHEMICAL CO.,LTD

Tel: +86-0512-83500002 +8618662433356
Email: 3899766280@qq.com
Country: China
ProdList: 26362
Advantage: 58

Young Lively PharminBlock Co.,Ltd

Tel: +undefined18600731423
Email: jason_gao@yl-pharminblock.com
Country: China
ProdList: 1944
Advantage: 58

Less

View Lastest Price from 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE manufacturers

Career Henan Chemical Co

Product: 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE 24310-36-9
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-04

24310-36-9, 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONERelated Search:

N-(2-FORMYLPHENYL)-4-METHYL-BENZENESULF& 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one 1,2,3,4-TETRAHYDRO-4-(HYDROXYMETHYLENE)-1-[(4-METHYLPHENYL)SULFONYL]-5H-1-BENZAZEPIN-5-ONE 2,3,4,5-Tetrahydro-1H-benzo[b]azepine 4-BROMO-1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE 1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE

1,2,3,4-Tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one

1-Tosyl-2,3,4,5-tetrahydro-1H-1-benzazepine-5-one

1-Tosyl-2,3-dihydro-1H-1-benzazepine-5(4H)-one

1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE

1-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

1-[(4-Methylbenzene)sulfonyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one

1,2,3,4-tetrahydro-1-tosylbenzo[b]azepin-5-one

1,2,3,4-tetrahydro-1-(4-Methylbenzenesulfonyl)-1-benzazepin-5-one

1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one

5H-1-Benzazepin-5-one, 1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-

1-(4-methylphenyl)sulfonyl-3,4-dihydro-2H-1-benzazepin-5-one

1,2,3,4-tetrahydro-1-(4-methylbenzenesulfonyl)-1-benzazepin-...

1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROB

24310-36-9

pharmacetical