2,4-DICHLORO-1,8-NAPHTHYRIDINE
Uses- Product Name
- 2,4-DICHLORO-1,8-NAPHTHYRIDINE
- CAS No.
- 59514-89-5
- Chemical Name
- 2,4-DICHLORO-1,8-NAPHTHYRIDINE
- Synonyms
- 2,4-DICHLORO-1,8-NAPHTHYRIDINE;1,8-Naphthyridine, 2,4-dichloro-;2,4-Dichloro-1,8-diazanaphthalene;2,4-Dichloro-1,8-naphthyridine>2,4-Dichloro-pyrido[2,3-b]pyridine;2,4-dichloro-1,8-naphthyridine CAS：59514-89-5;3-(2-Hydroxyethyl)-2-Methyl-3,4-dihydro-4-quinazolinone
- CBNumber
- CB61215876
- Molecular Formula
- C8H4Cl2N2
- Formula Weight
- 199.04
- MOL File
- 59514-89-5.mol
2,4-DICHLORO-1,8-NAPHTHYRIDINE Property
- Melting point:
- 123.0 to 127.0 °C
- Boiling point:
- 299℃
- Density
- 1.486
- Flash point:
- 163℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- pka
- 1.15±0.30(Predicted)
- color
- Light yellow to Yellow to Orange
Safety
- HS Code
- 2933.99.8290
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- D4896
- Product name
- 2,4-Dichloro-1,8-naphthyridine
- Purity
- >96.0%(GC)(T)
- Packaging
- 1g
- Price
- $154
- Updated
- 2025/07/31
- Product number
- D437540
- Product name
- 2,4-Dichloro-1,8-naphthyridine
- Packaging
- 100mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 44552
- Product name
- 2,4-Dichloro-1,8-naphthyridine,≥96%(GC)
- Purity
- ≥96%(GC)
- Packaging
- 100G
- Price
- $115.01
- Updated
- 2021/12/16
- Product number
- 8858AB
- Product name
- 2,4-Dichloro-1,8-naphthyridine
- Packaging
- 5g
- Price
- $373
- Updated
- 2021/12/16
- Product number
- HCH0117364
- Product name
- 2,4-DICHLORO-1,8-NAPHTHYRIDINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $780.15
- Updated
- 2021/12/16
2,4-DICHLORO-1,8-NAPHTHYRIDINE Chemical Properties,Usage,Production
Uses
2,4-Dichloro-1,8-diazonphthalene can be used to prepare the compound 4-chloro-1,8-diazonphthalene, which is an important intermediate in the synthesis of naphthidine derivatives. Naphthidine derivatives exert their effects by inhibiting, regulating, and/or modulating signal transduction through ATP-consuming proteins such as kinases.
Synthesis
219775-95-8
59514-89-5
583031-57-6
1-Benzyl-4-hydroxy-1,8-naphthyridin-2(1H)-one (2.52 g, 10 mmol) was used as a raw material, which was dissolved in phosphoryl chloride (100 mL) and heated to reflux for 2 hours. After the reaction was completed, it was cooled to room temperature and the reaction mixture was slowly added dropwise to crushed ice while stirring. The reaction solution was neutralized with sodium hydroxide solution and subsequently extracted with ethyl acetate. The organic phase was separated, washed with saturated brine and dried over anhydrous sodium sulfate. After concentration under reduced pressure to remove the solvent, purification by column chromatography afforded 1-benzyl-4-chloro-1,8-naphthyridin-2(1H)-one (1.26 g, 47% yield) and 2,4-dichloro-1,8-diazanaphthalene (556 mg, 28% yield). 1-Benzyl-4-chloro-1,8-naphthyridin-2(1H)-one: 1H NMR (500 MHz, CDCl3) δ 8.64 (d, J = 3.0 Hz, 1H), 8.22 (d, J = 7.0 Hz, 1H), 7.49 (d, J = 7.0 Hz, 2H), 7.21-7.28 (m, 4H), 6.94 (s, 1H), 5.73 (s, 2H); 13C NMR (125 MHz, CDCl3) δ 161.62, 151.31, 149.38, 143.20, 137.49, 134.57, 128.92, 128.55, 127.58, 122.40, 118.80, 115.00, 44.56; LCMS (EI) m/z 270.9 (M+), 273.0. 2,4-Dichloro-1,8-diazanaphthalene: 1H NMR (500 MHz, CDCl3) δ 9.10 (d, J = 3.0 Hz, 1H), 8.51 (d, J = 8.5 Hz, 1H), 7.57 (dd, J = 8.5, 3.0 Hz, 1H), 7.54 (s, 1H); 13C NMR (125 MHz, CDCl3) δ 155.63, 155.39, 153.62, 144.70, 133.97, 123.38, 123.36, 120.69; LCMS (EI) m/z 198.9 (M+), 200.7, 203.0.
References
[1] Patent: WO2008/24423, 2008, A2. Location in patent: Page/Page column 43
[2] Patent: US2009/54477, 2009, A1. Location in patent: Page/Page column 18
2,4-DICHLORO-1,8-NAPHTHYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-DICHLORO-1,8-NAPHTHYRIDINE manufacturers
- Product
- 2,4-DICHLORO-1,8-NAPHTHYRIDINE 59514-89-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-30