Uses
ChemicalBook > CAS DataBase List > 2,4-DICHLORO-1,8-NAPHTHYRIDINE

2,4-DICHLORO-1,8-NAPHTHYRIDINE

Uses
Product Name
2,4-DICHLORO-1,8-NAPHTHYRIDINE
CAS No.
59514-89-5
Chemical Name
2,4-DICHLORO-1,8-NAPHTHYRIDINE
Synonyms
2,4-DICHLORO-1,8-NAPHTHYRIDINE;1,8-Naphthyridine, 2,4-dichloro-;2,4-Dichloro-1,8-diazanaphthalene;2,4-Dichloro-1,8-naphthyridine>2,4-Dichloro-pyrido[2,3-b]pyridine;2,4-dichloro-1,8-naphthyridine CAS：59514-89-5;3-(2-Hydroxyethyl)-2-Methyl-3,4-dihydro-4-quinazolinone
CBNumber
CB61215876
Molecular Formula
C8H4Cl2N2
Formula Weight
199.04
MOL File
59514-89-5.mol
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2,4-DICHLORO-1,8-NAPHTHYRIDINE Property

Melting point:
123.0 to 127.0 °C
Boiling point:
299℃
Density 
1.486
Flash point:
163℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to crystal
pka
1.15±0.30(Predicted)
color 
Light yellow to Yellow to Orange
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Safety

HS Code 
2933.99.8290
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D4896
Product name
2,4-Dichloro-1,8-naphthyridine
Purity
>96.0%(GC)(T)
Packaging
1g
Price
$154
Updated
2025/07/31
TRC
Product number
D437540
Product name
2,4-Dichloro-1,8-naphthyridine
Packaging
100mg
Price
$155
Updated
2021/12/16
Chem-Impex
Product number
44552
Product name
2,4-Dichloro-1,8-naphthyridine,≥96%(GC)
Purity
≥96%(GC)
Packaging
100G
Price
$115.01
Updated
2021/12/16
AK Scientific
Product number
8858AB
Product name
2,4-Dichloro-1,8-naphthyridine
Packaging
5g
Price
$373
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0117364
Product name
2,4-DICHLORO-1,8-NAPHTHYRIDINE
Purity
95.00%
Packaging
1G
Price
$780.15
Updated
2021/12/16
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2,4-DICHLORO-1,8-NAPHTHYRIDINE Chemical Properties,Usage,Production

Uses

2,4-Dichloro-1,8-diazonphthalene can be used to prepare the compound 4-chloro-1,8-diazonphthalene, which is an important intermediate in the synthesis of naphthidine derivatives. Naphthidine derivatives exert their effects by inhibiting, regulating, and/or modulating signal transduction through ATP-consuming proteins such as kinases.

Synthesis

219775-95-8

59514-89-5

583031-57-6

1-Benzyl-4-hydroxy-1,8-naphthyridin-2(1H)-one (2.52 g, 10 mmol) was used as a raw material, which was dissolved in phosphoryl chloride (100 mL) and heated to reflux for 2 hours. After the reaction was completed, it was cooled to room temperature and the reaction mixture was slowly added dropwise to crushed ice while stirring. The reaction solution was neutralized with sodium hydroxide solution and subsequently extracted with ethyl acetate. The organic phase was separated, washed with saturated brine and dried over anhydrous sodium sulfate. After concentration under reduced pressure to remove the solvent, purification by column chromatography afforded 1-benzyl-4-chloro-1,8-naphthyridin-2(1H)-one (1.26 g, 47% yield) and 2,4-dichloro-1,8-diazanaphthalene (556 mg, 28% yield). 1-Benzyl-4-chloro-1,8-naphthyridin-2(1H)-one: 1H NMR (500 MHz, CDCl3) δ 8.64 (d, J = 3.0 Hz, 1H), 8.22 (d, J = 7.0 Hz, 1H), 7.49 (d, J = 7.0 Hz, 2H), 7.21-7.28 (m, 4H), 6.94 (s, 1H), 5.73 (s, 2H); 13C NMR (125 MHz, CDCl3) δ 161.62, 151.31, 149.38, 143.20, 137.49, 134.57, 128.92, 128.55, 127.58, 122.40, 118.80, 115.00, 44.56; LCMS (EI) m/z 270.9 (M+), 273.0. 2,4-Dichloro-1,8-diazanaphthalene: 1H NMR (500 MHz, CDCl3) δ 9.10 (d, J = 3.0 Hz, 1H), 8.51 (d, J = 8.5 Hz, 1H), 7.57 (dd, J = 8.5, 3.0 Hz, 1H), 7.54 (s, 1H); 13C NMR (125 MHz, CDCl3) δ 155.63, 155.39, 153.62, 144.70, 133.97, 123.38, 123.36, 120.69; LCMS (EI) m/z 198.9 (M+), 200.7, 203.0.

References

[1] Patent: WO2008/24423, 2008, A2. Location in patent: Page/Page column 43
[2] Patent: US2009/54477, 2009, A1. Location in patent: Page/Page column 18

2,4-DICHLORO-1,8-NAPHTHYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-DICHLORO-1,8-NAPHTHYRIDINE Suppliers

Americas 1 China 93 Europe 1 Germany 1 India 3 Japan 1 United States 6 Global 106
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from 2,4-DICHLORO-1,8-NAPHTHYRIDINE manufacturers

Career Henan Chemical Co
Product
2,4-DICHLORO-1,8-NAPHTHYRIDINE 59514-89-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-30

59514-89-5, 2,4-DICHLORO-1,8-NAPHTHYRIDINERelated Search:

2,6-DIMETHYLNAPHTHALENE Dichlorodihydrosilane 4,4'-Dichlorodiphenyl sulfone Heptaldehyde Trimethylaluminium 2,4-DICHLORO-1,8-NAPHTHYRIDINE BUTTPARK 109\40-21 AKOS 90485 BUTTPARK 109\40-22 AKOS 90513

  • 2,4-DICHLORO-1,8-NAPHTHYRIDINE
  • 3-(2-Hydroxyethyl)-2-Methyl-3,4-dihydro-4-quinazolinone
  • 2,4-Dichloro-1,8-naphthyridine&gt
  • 1,8-Naphthyridine, 2,4-dichloro-
  • 2,4-Dichloro-1,8-diazanaphthalene
  • 2,4-Dichloro-pyrido[2,3-b]pyridine
  • 2,4-dichloro-1,8-naphthyridine CAS：59514-89-5
  • 59514-89-5