6,7-Dimethoxy-4-[N-(3-chlorophenyl)amino]quinazoline hydrochloride
- Product Name
- 6,7-Dimethoxy-4-[N-(3-chlorophenyl)amino]quinazoline hydrochloride
- CAS No.
- 170449-18-0
- Chemical Name
- 6,7-Dimethoxy-4-[N-(3-chlorophenyl)amino]quinazoline hydrochloride
- Synonyms
- AG1478 HCl (Tyrphostin AG-1478);1-Propanone,1-[4-(6-methylethyl)phenyl]-;2(1H)-Quinolinone,3,4-dihydro-11-hydroxy-;-6,7-dimethoxyquinazolin-4-amine hydrochloride;N-(3-chlorophenyl)-6,7-dimethoxy- hydrochloride;N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine HCl;N-(3-chlorophenyl)-6,7-diMethoxyquinazolin-4-aMine hydrochloride;N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine hydrochloride;6,7-Dimethoxy-4-[N-(3-chlorophenyl)amino]quinazoline hydrochloride;1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
- CBNumber
- CB61216035
- Molecular Formula
- C16H14ClN3O2.HCl
- Formula Weight
- 0
- MOL File
- 170449-18-0.mol
6,7-Dimethoxy-4-[N-(3-chlorophenyl)amino]quinazoline hydrochloride Property
- Melting point:
- 230-235 °C
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A3666
- Product name
- AG 1478 Hydrochloride
- Packaging
- 25MG
- Price
- $154
- Updated
- 2026/03/19
- Product number
- A427025
- Product name
- AG1478Hydrochloride
- Packaging
- 10mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- W3717
- Product name
- N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-aminehydrochloride
- Packaging
- 100mg
- Price
- $238
- Updated
- 2021/12/16
- Product number
- FC42010
- Product name
- N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride
- Packaging
- 10mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- FC42010
- Product name
- N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride
- Packaging
- 25mg
- Price
- $325
- Updated
- 2021/12/16
6,7-Dimethoxy-4-[N-(3-chlorophenyl)amino]quinazoline hydrochloride Chemical Properties,Usage,Production
Uses
AG-1478 hydrochloride (Tyrphostin AG-1478 hydrochloride) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 hydrochloride has antiviral effects against HCV and encephalomyocarditis virus (EMCV)[1][2][3][4].
Definition
ChEBI: A member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist.
in vivo
Administration of AG-1478 (AG1478) significantly reduces myocardial inflammation, fibrosis, apoptosis, and dysfunction in both two obese mouse models. ApoE-/- mice are first fed with HFD for 8 weeks (ApoE-HFD), and then administrated with AG-1478 (10 mg/kg/day) or 542 (10 mg/kg/day) for another 8 weeks by oral gavage. AG-1478 or 542 treatment blocks HFD induced cardiac EGFR phosphorylation in vivo, without affecting the plasma level of low density lipoprotein (LDL) and total triglyceride (TG)[2]. Administration of EGF (10 nM) leads to a robust and reproducible elevation in EGFR phosphorylation that can be blocked by AG-1478 (AG1478), a known inhibitor of EGFR phosphorylation. Increasing doses of Polyfect (PF) result in a significant reduction in EGF-induced EGFR phosphorylation (p<0.05) but this is to a lesser extent than observed with AG1478[3].
IC 50
EGFR: 3 nM (IC50); HCV; EMCV
storage
Desiccate at -20°C
References
[1] Bojko A, et al. The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells. Folia Histochem Cytobiol. 2012 Jul 5;50(2):186-95. DOI:10.5603/fhc.2012.0028
[2] Li W, et al. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Sci Rep. 2016 Apr 18;6:24580. DOI:10.1038/srep24580
[3] Akhtar S, et al. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PLoS One. 2015 Jul 13;10(7):e0132215. DOI:10.1371/journal.pone.0132215
[4] Dorobantu CM, et al. Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6402-6. DOI:10.1128/AAC.01331-16
6,7-Dimethoxy-4-[N-(3-chlorophenyl)amino]quinazoline hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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