PHENYLMERCURIC BORATE Property

Melting point:

112-113°

form 

solid

CAS DataBase Reference

102-98-7(CAS DataBase Reference)

EPA Substance Registry System

Mercurate(2-), [orthoborato(3-)-.kappa.O]phenyl-, dihydrogen (102-98-7)

Safety

Risk Statements 

28-36/37/38

Safety Statements 

26-36/37/39

RIDADR 

2026

HazardClass 

6.1(a)

PackingGroup 

II

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H310Fatal in contact with skin

H330Fatal if inhaled

H362May cause harm to breast-fed children

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

PHENYLMERCURIC BORATE Chemical Properties,Usage,Production

Chemical Properties

Phenylmercuric borate occurs as colorless, shiny flakes or as a white or slightly yellow, odorless, crystalline powder.

Production Methods

Phenylmercuric borate may be prepared by heating mercuric borate with benzene or by evaporating to dryness, under vacuum, an alcoholic solution containing equimolar proportions of phenylmercuric hydroxide and boric acid.

Pharmaceutical Applications

Phenylmercuric borate is used as an alternative antimicrobial preservative to phenylmercuric acetate or phenylmercuric nitrate. It is more soluble than phenylmercuric nitrate and has also been reported to be less irritant than either phenylmercuric acetate or phenylmercuric nitrate.

Safety

Phenylmercuric borate is mainly used as an antimicrobial preservative in topical pharmaceutical formulations. A number of adverse reactions to mercury-containing preservatives have been reported; see Phenylmercuric Nitrate.
Although phenylmercuric borate is an irritant, it has been reported to be less so than either phenylmercuric acetate or phenylmercuric nitrate.(1) There is, however, some cross-sensitization potential with other mercurial preservatives. Systemic absorption has been reported following regular use of a hand disinfectant soap containing 0.04% phenylmercuric borate, resulting in an increase in the estimated total daily body load of mercury from 30–100 mg per 24 hours.

storage

As for other phenylmercuric salts; see Phenylmercuric Nitrate. Solutions may be sterilized by autoclaving.
Phenylmercuric borate should be stored in a well-closed container, protected from light, in a cool, dry place.

Incompatibilities

Incompatible with: halides; anionic emulsifying agents and suspending agents; tragacanth; starch; talc; sodium metabisulfite; sodium thiosulfate; disodium edetate; silicates; aluminum and other metals; amino acids; ammonia and ammonium salts; sulfur compounds; rubber; and some plastics.
Phenylmercuric acetate is reported to be incompatible with cefuroxime and ceftazidime.

Regulatory Status

Included in nonparenteral medicines licensed in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients (ophthalmic, nasal and otic preparations up to 0.004%; there must be no other suitable alternative preservative).
In Europe, use is limited to eye makeup and eye makeup remover at not more than 0.007% mercury alone or in combination with other permitted mercurial substances.In France, a maximum concentration of up to 0.01% is permitted for use in pharmaceutical formulations. Prohibited from use in cosmetic products in Canada. Prohibited in antimicrobial diaper rash drug products in the USA. Limited use in Japan (see Phenylmercuric Nitrate).