Irinotecan hydrochloride trihydrate

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Irinotecan hydrochloride trihydrate

Product Name: Irinotecan hydrochloride trihydrate
CAS No.: 136572-09-3
Chemical Name: Irinotecan hydrochloride trihydrate
Synonyms: Iriontecan HCL;Irinotecan HCL 3H2O;Irinotecan HydrochL;Irinotecan Trihydrate;CPT-11 HCl Trihydrate;Irinotecan Hydrochlorid;IRINOTECAN HCL TRIHYDRATE;IRINOTECON HCL TRIHYDRATE;Irinotecan HCI Trihydrate;trihydrate,(s)-hydrochlorid
CBNumber: CB6122430
Molecular Formula: C33H45ClN4O9
Formula Weight: 677.18
MOL File: 136572-09-3.mol

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Irinotecan hydrochloride trihydrate Property

Melting point:: 250-256°C (dec.)
Boiling point:: 257°C(lit.)
storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml).
form: White solid.
color: Yellow
Water Solubility: Soluble in DMSO at 100mg/ml. Soluble in water at 25mg/ml with warming
Merck: 14,5091
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference: 136572-09-3(CAS DataBase Reference)

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Safety

Risk Statements: 22
Safety Statements: 20/21-22
RTECS: DW1060750
HS Code: 29349990
Toxicity: dog,LD50,intravenous,40mg/kg (40mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P314Get medical advice/attention if you feel unwell.

P330Rinse mouth.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1347609
Product name: Irinotecan hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 100MG
Price: $698
Updated: 2024/03/01

TCI Chemical

Product number: I0714
Product name: Irinotecan Hydrochloride Trihydrate
Purity: >98.0%(HPLC)(T)
Packaging: 100mg
Price: $84
Updated: 2024/03/01

Alfa Aesar

Product number: J62370
Product name: Irinotecan hydrochloride trihydrate
Purity: 99%
Packaging: 100mg
Price: $172.65
Updated: 2024/03/01

Alfa Aesar

Product number: J62370
Product name: Irinotecan hydrochloride trihydrate
Purity: 99%
Packaging: 250mg
Price: $337.65
Updated: 2024/03/01

Cayman Chemical

Product number: 14180
Product name: Irinotecan (hydrochloride hydrate)
Packaging: 100mg
Price: $96
Updated: 2024/03/01

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Irinotecan hydrochloride trihydrate Chemical Properties,Usage,Production

Description

Irinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38, Cat.# 10-2425), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3

Chemical Properties

White powder

Uses

Irinotecan Hydrochloride Trihydrate is a DNA topoisomerase inhibitor.

Definition

ChEBI: A hydrate that is the trihydrate form of irinotecan hydrochloride. Onivyde is used in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.

brand name

Camptosar (Pharmacia &Upjohn) .

Hazard

Moderately toxic by ingestion.

References

1) Kunimoto et al. (1987) Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin, a novel water-soluble derivative of camptothecin against murine tumors; Cancer Res., 47 5944 2) Mathijssen et al., (2002) Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11) and topotecan; Curr. Cancer Drug Targets, 253 5892 3) Pfizer drug insert

Irinotecan hydrochloride trihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Irinotecan hydrochloride trihydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Irinotecan hydrochloride trihydrate 136572-09-3
Price: US $0.00/g/Bag
Min. Order: 1g
Purity: 98%-102%; USP
Supply Ability: 1000G
Release date: 2021-07-19

Hebei Mojin Biotechnology Co., Ltd

Product: Irinotecan hydrochloride trihydrate 136572-09-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-11

Hebei Guanlang Biotechnology Co., Ltd.

Product: Irinotecan hydrochloride trihydrate 136572-09-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-09-10

136572-09-3, Irinotecan hydrochloride trihydrateRelated Search:

Irinotecan Impurity 18 (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Irinotecan hydrochloride 12-Hydroxy Irinotecan GURKHSYORGJETM-MGDILKBHSA-N Irinotecan Impurity 19 Irinotecan Impurity 24 Cisplatin 5-Fluorouracil Topotecan hydrochloride Crizotinib Oxaliplatin Olaparib Mesna Docetaxel 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride 1-benzyl-4-(piperidin-1-yl)-1,2,3,6-tetrahydropyridine [1,4'-Bipiperidine]-1'-carboxylic acid

Irinotecan hydrochloride trihydrate, >=99%

(1,4’-bipiperidine)-1’-carboxylicacid,4,11-diethyl-3,4,12,14-tetrahydro-4-hyd

roxy-3,14-dioxo-1h-pyrano(3’,4’:6,7)indolizino(1,2-b)quinolin-9-ylester,mono

trihydrate,(s)-hydrochlorid

IRINOTECAN HYDROCHLORIDE TRIHYDRATE

IRINOTECAN MONOHYDROCHLORIDE TRIHYDRATE

IRINOTECAN HCL TRIHYDRATE

Irinotecan HCL 3H2O

rinotecan hydrochloride trihydrate

Iriontecan HCL

CPT 11; CAMPTOSAR; CAMPTO; IRINOTECAN

(s)-[1,4'-bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate

Irinotecan Hydrochlorid

Irinotecanhydrochloridetrihydrate(CPT-11)

IRINOTECON HCL TRIHYDRATE

[1,4'-BIPIPERIDINE]-1'-CARBOXYLIC ACID (S)-4,11-DIETHYL-3,4,12,14-TETRAHYDRO-4-HYDROXY-3,14-DIOXO-1H-PYRANO[3',4',6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL ESTER, HCL TRIHYDRATE

(S)-[1,4'-Bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate ,99%

Irinotecan Hydrochloride (100 mg)

Irinotecan Hydrochloride&nbsp

Irinotecan Trihydrate

[1,4'-Bipiperidine]-1'-carboxylicacid,(4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-ylester,hydrochloride,hydrate(1:1:3)

Irinotecan HCl Trihydrate (CaMpto)

Irinotecan, Hydrochloride Salt, Trihydrate

Irinotecan-d10 hydrochloride trihydrate

CPT-11 HCl Trihydrate

irinotecan hydrochloride hydrate

7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin Hydrochloride Trihydrate

Irinotecan hydrochloride trihydrate CRS

Irinotecan for peak identification

Irinotican Hydrochloride Trihydrate

IrinotecanHydrochlorideTrihydrate&gt

Irinotecan HydrochL

Irincan hydrochloride trihydrate

Irinotecan hydrochloride trihydrate USP/EP/BP

Irinotican Hydrochloride TrihydrateQ: What is Irinotican Hydrochloride Trihydrate Q: What is the CAS Number of Irinotican Hydrochloride Trihydrate Q: What is the storage condition of Irinotican Hydrochloride Trihydrate Q: What are the applications of Irinotican Hydrochloride Trihydrate

Irinotecan for peak identification (Y0001831)

Irinotecan for system suitability 1 (Y0001830)

Irinotecan for system suitability 2 (Y0001833)

Irinotecan Hydrochloride (1347609)

Irinotecan hydrochloride trihydrate (Y0001832)

Irinotecan HCI Trihydrate

(S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate

Irinotecan hydrochloride trihydrate 98%

(S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-9-yl [1,4’-Bipiperidine]-1’-carboxylate Hydrochloride Trihydrate

Irinotecan (CPT-11) HCl Trihydrate

(S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate

136572-09-3

6572-09-3

36572-09-3

C33H38N4O6HCl3H2O

C33H38N4O6ClH3H2O

C33H45ClN4O9

Inhibitors

Anticancer

Anti-cancer&immunity

API