ChemicalBook > CAS DataBase List > Irinotecan hydrochloride trihydrate

Irinotecan hydrochloride trihydrate

Product Name
Irinotecan hydrochloride trihydrate
CAS No.
136572-09-3
Chemical Name
Irinotecan hydrochloride trihydrate
Synonyms
Iriontecan HCL;Irinotecan HCL 3H2O;Irinotecan HydrochL;Irinotecan Trihydrate;CPT-11 HCl Trihydrate;Irinotecan Hydrochlorid;IRINOTECAN HCL TRIHYDRATE;IRINOTECON HCL TRIHYDRATE;Irinotecan HCI Trihydrate;trihydrate,(s)-hydrochlorid
CBNumber
CB6122430
Molecular Formula
C33H45ClN4O9
Formula Weight
677.18
MOL File
136572-09-3.mol
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Irinotecan hydrochloride trihydrate Property

Melting point:
250-256°C (dec.)
Boiling point:
257°C(lit.)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml).
form 
White solid.
color 
Yellow
Water Solubility 
Soluble in DMSO at 100mg/ml. Soluble in water at 25mg/ml with warming
Merck 
14,5091
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference
136572-09-3(CAS DataBase Reference)
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Safety

Risk Statements 
22
Safety Statements 
20/21-22
RTECS 
DW1060750
HS Code 
29349990
Toxicity
dog,LD50,intravenous,40mg/kg (40mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P314Get medical advice/attention if you feel unwell.

P330Rinse mouth.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1347609
Product name
Irinotecan hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100MG
Price
$698
Updated
2024/03/01
TCI Chemical
Product number
I0714
Product name
Irinotecan Hydrochloride Trihydrate
Purity
>98.0%(HPLC)(T)
Packaging
100mg
Price
$84
Updated
2024/03/01
Alfa Aesar
Product number
J62370
Product name
Irinotecan hydrochloride trihydrate
Purity
99%
Packaging
100mg
Price
$172.65
Updated
2024/03/01
Alfa Aesar
Product number
J62370
Product name
Irinotecan hydrochloride trihydrate
Purity
99%
Packaging
250mg
Price
$337.65
Updated
2024/03/01
Cayman Chemical
Product number
14180
Product name
Irinotecan (hydrochloride hydrate)
Packaging
100mg
Price
$96
Updated
2024/03/01
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Irinotecan hydrochloride trihydrate Chemical Properties,Usage,Production

Description

Irinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38, Cat.# 10-2425), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3

Chemical Properties

White powder

Uses

Irinotecan Hydrochloride Trihydrate is a DNA topoisomerase inhibitor.

Definition

ChEBI: A hydrate that is the trihydrate form of irinotecan hydrochloride. Onivyde is used in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.

brand name

Camptosar (Pharmacia &Upjohn) .

Hazard

Moderately toxic by ingestion.

References

1) Kunimoto et al. (1987) Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin, a novel water-soluble derivative of camptothecin against murine tumors; Cancer Res., 47 5944 2) Mathijssen et al., (2002) Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11) and topotecan; Curr. Cancer Drug Targets, 253 5892 3) Pfizer drug insert

Irinotecan hydrochloride trihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Irinotecan hydrochloride trihydrate Suppliers

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View Lastest Price from Irinotecan hydrochloride trihydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Irinotecan hydrochloride trihydrate 136572-09-3
Price
US $0.00/g/Bag
Min. Order
1g
Purity
98%-102%; USP
Supply Ability
1000G
Release date
2021-07-19
Hebei Weibang Biotechnology Co., Ltd
Product
Irinotecan hydrochloride trihydrate 136572-09-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-28
Hangzhou Hyper Chemicals Limited
Product
Irinotecan hydrochloride trihydrate 136572-09-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%, USP
Supply Ability
5,000KG
Release date
2024-08-22

136572-09-3, Irinotecan hydrochloride trihydrateRelated Search:

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  • Irinotecan hydrochloride trihydrate, >=99%
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  • trihydrate,(s)-hydrochlorid
  • IRINOTECAN HYDROCHLORIDE TRIHYDRATE
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  • Iriontecan HCL
  • CPT 11; CAMPTOSAR; CAMPTO; IRINOTECAN
  • (s)-[1,4'-bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate
  • Irinotecan Hydrochlorid
  • Irinotecanhydrochloridetrihydrate(CPT-11)
  • IRINOTECON HCL TRIHYDRATE
  • [1,4'-BIPIPERIDINE]-1'-CARBOXYLIC ACID (S)-4,11-DIETHYL-3,4,12,14-TETRAHYDRO-4-HYDROXY-3,14-DIOXO-1H-PYRANO[3',4',6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL ESTER, HCL TRIHYDRATE
  • (S)-[1,4'-Bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate ,99%
  • Irinotecan Hydrochloride (100 mg)
  • Irinotecan Hydrochloride&nbsp
  • Irinotecan Trihydrate
  • [1,4'-Bipiperidine]-1'-carboxylicacid,(4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-ylester,hydrochloride,hydrate(1:1:3)
  • Irinotecan HCl Trihydrate (CaMpto)
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  • IrinotecanHydrochlorideTrihydrate&gt
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  • Irinotican Hydrochloride TrihydrateQ: What is Irinotican Hydrochloride Trihydrate Q: What is the CAS Number of Irinotican Hydrochloride Trihydrate Q: What is the storage condition of Irinotican Hydrochloride Trihydrate Q: What are the applications of Irinotican Hydrochloride Trihydrate
  • Irinotecan for peak identification (Y0001831)
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  • Irinotecan Hydrochloride (1347609)
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  • Irinotecan HCI Trihydrate
  • (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate
  • Irinotecan hydrochloride trihydrate 98%
  • (S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-9-yl [1,4’-Bipiperidine]-1’-carboxylate Hydrochloride Trihydrate
  • Irinotecan (CPT-11) HCl Trihydrate
  • (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate
  • (S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-9-yl [1,4’-Bipiperidine]-1’-carboxylate Hydrochloride Trihydrate
  • 136572-09-3
  • 6572-09-3
  • 36572-09-3
  • C33H38N4O6HCl3H2O
  • C33H38N4O6ClH3H2O
  • C33H45ClN4O9
  • Inhibitors
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  • Anti-cancer&immunity
  • API