CLOBENPROPIT DIHYDROBROMIDE

Product Name: CLOBENPROPIT DIHYDROBROMIDE
CAS No.: 145231-45-4
Chemical Name: CLOBENPROPIT DIHYDROBROMIDE
Synonyms: CS-683;VUF 9153;Clobenpropit 2HBr;Clobenpropit dihydro;VUF 9153 DIHYDROBROMIDE;CLOBENPROPIT DIHYDROBROMIDE;Clobenpropit dihydrobromide solid;Clobenpropit dihydrobromide, 95%min;N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA;S-(3-(4(5)-Imidazolyl))propyl-N-(4-chlorobenzyl)isothiourea
CBNumber: CB6122647
Molecular Formula: C14H17ClN4S
Formula Weight: 308.83
MOL File: 145231-45-4.mol

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CLOBENPROPIT DIHYDROBROMIDE Property

Boiling point:: 525.3±60.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: H₂O: >20 mg/mL
pka: 14.55±0.10(Predicted)
form: solid
color: white
Water Solubility: H2O: >20mg/mL
ethanol: 3.30mg/mL
DMSO: >30mg/mL

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 0752
Product name: Clobenpropit dihydrobromide
Purity: ≥99%(HPLC)
Packaging: 10
Price: $193
Updated: 2021/12/16

Tocris

Product number: 0752
Product name: Clobenpropit dihydrobromide
Purity: ≥99%(HPLC)
Packaging: 50
Price: $810
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BRS0000115
Product name: CLOBENPROPIT
Purity: 99.00%
Packaging: 100MG
Price: $2116.25
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BRS0000115
Product name: CLOBENPROPIT
Purity: 99.00%
Packaging: 10MG
Price: $782.23
Updated: 2021/12/16

Crysdot

Product number: CD11253884
Product name: Clobenpropit
Purity: 95+%
Packaging: 50mg
Price: $790
Updated: 2021/12/16

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CLOBENPROPIT DIHYDROBROMIDE Chemical Properties,Usage,Production

Uses

Clobenpropit Dihydrobromide and it’s analogues functions as potent histamine H3 antagonist.

Definition

ChEBI: An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA

Biological Activity

An extremely potent histamine H 3 antagonist/inverse agonist (pA 2 =9.93). Also displays partial agonist activity at H 4 receptors; induces eosinophil shape change with an EC 50 of 3 nM. Also available as part of the Histamine H 3 Receptor Tocriset™ .

Biochem/physiol Actions

Selective H3 histamine receptor antagonist that crosses the blood-brain barrier.

in vivo

Clobenpropit (15 mg/kg; i.p.; once daily for 7 days) counteracts the modulatory effects of MK-801 (HY-15084B) on dopamine and histamine levels and prevents MK-801-induced hyper locomotor behaviors^[1].
Clobenpropit (1, 2, 5 μmoL/kg; i.v.) causes a resuscitating effect in rats subjected to the hemorrhagic shock^[2].

Animal Model:	150-200g, 12-week-old male wistar albino rats^[1]
Dosage:	15 mg/kg
Administration:	I.p.; once daily for 7 days
Result:	Exhibited a significant reduction of hyperlocomotor activities induced by a single-dose administration of MK-801 (0.2 mg/kg, i.p.), and reduced the MK-801-induced dopamine release, exhibited further increase in histamine levels in the hypothalamus.

Animal Model:	205-470g, adult male Wistar rats^[2]
Dosage:	1, 2, 5 μmoL/kg (after 6-hydroxydopamine (50 mg/kg (SC) for 3 consecutive days)
Administration:	I.v.
Result:	Triggered a statistically significant increase of mean arterial pressure (MAP) (dose 2 μmol/kg) and heart rate (HR) (doses of 1, 2, 5 μmol/kg).

IC 50

H₃ receptor

CLOBENPROPIT DIHYDROBROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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CLOBENPROPIT DIHYDROBROMIDE Suppliers

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145231-45-4, CLOBENPROPIT DIHYDROBROMIDERelated Search:

CLOBENPROPIT DIHYDROBROMIDE, VUF 9153 CLOBENPROPIT DIHYDROBROMIDE N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA

N-(4-Chlorobenzyl)-S-[3-(4(5)-imidazoyl)propyl]isothiourea dihydrobromide

3-(1H-Imidazol-4-yl)propyl ((4-chlorophenyl)methyl)carbamimidothioate

Carbamimidothioic acid, ((4-chlorophenyl)methyl)-, 3-(1H-imidazol-4-yl)propyl ester

S-(3-(4(5)-Imidazolyl))propyl-N-(4-chlorobenzyl)isothiourea

CarbaMiMidothioic acid, N-[(4-chlorophenyl)Methyl]-, 3-(1H-iMidazol-5-yl)propyl ester

[(4-Chlorophenyl)methyl]carbamimidothioic acid 3-(1H-imidazol-4-yl)propyl ester

([4-CHLOROPHENYL]METHYL)-3-(1H-IMIDAZOL-4-YL)PROPYL ESTER CARBAMIMIDOTHIOIC ACID DIHYDROBROMIDE

CLOBENPROPIT DIHYDROBROMIDE

VUF 9153

VUF 9153 DIHYDROBROMIDE

N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA

N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA DIHYDROBROMIDE

VUF 9153, [(4-Chlorophenyl)methyl]-3-(1H-imidazol-4-yl)propyl ester carbamimidothioic acid dihydrobromide

CS-683

Clobenpropit dihydrobromide solid

Clobenpropit dihydro

Clobenpropit 2HBr

3-(1H-imidazol-5-yl)propyl N'-(4-chlorobenzyl)carbamimidothioate

Clobenpropit dihydrobromide, 95%min

145231-45-4

C14H17ClN4S2HBr

Histamine receptor