2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid
- Product Name
- 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid
- CAS No.
- 484-78-6
- Chemical Name
- 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid
- Synonyms
- NSC 96400;Paralysin II;3-hydroxykynurenine;DL-Hydroxykynurenine;rac 3-Hydroxy Kynurenine;3-(3-Hydroxyanthraniloyl)alanine;REF DUPL: DL-3-Hydroxykynurenine;Benzenebutanoic acid, α,2-diamino-3-hydroxy-γ-oxo-;2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid;REF DUPL: 2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid
- CBNumber
- CB61236011
- Molecular Formula
- C10H12N2O4
- Formula Weight
- 224.21
- MOL File
- 484-78-6.mol
2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid Property
- Melting point:
- 213 °C (decomp)
- Boiling point:
- 365.61°C (rough estimate)
- Density
- 1.2995 (rough estimate)
- refractive index
- 1.6620 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMF: 0.5 mg/ml; DMSO: 1 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): 0.5 mg/ml
- form
- A crystalline solid
- pka
- 2.16±0.23(Predicted)
- color
- Light yellow to yellow
- Stability:
- Hygroscopic
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H1771
- Product name
- 3-Hydroxy-DL-kynurenine
- Packaging
- 25mg
- Price
- $167
- Updated
- 2024/03/01
- Product number
- H1771
- Product name
- 3-Hydroxy-DL-kynurenine
- Packaging
- 100mg
- Price
- $499
- Updated
- 2024/03/01
- Product number
- 78047
- Product name
- 3-Hydroxy-DL-kynurenine
- Purity
- analyticalstandard
- Packaging
- 10MG
- Price
- $127
- Updated
- 2024/03/01
- Product number
- 78047
- Product name
- 3-Hydroxy-DL-kynurenine
- Purity
- analyticalstandard
- Packaging
- 50MG
- Price
- $339
- Updated
- 2022/05/15
- Product number
- 27778
- Product name
- 3-hydroxy-DL-Kynurenine
- Packaging
- 10mg
- Price
- $68
- Updated
- 2024/03/01
2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid Chemical Properties,Usage,Production
Uses
3-Hydroxykynurenine is a metabolite of tryptophan. ential endogenous neurotoxin.
Uses
3-Hydroxy-DL-kynurenine is a tryptophan metabolite. Could be associated with symptoms in Parkinson''s disease.
Uses
3-Hydroxy-DL-kynurenine has been used:
- as a substrate for the recombinant human kynureninase assay
- as a reference standard in tandem mass spectrometry (MS/MS) analysis
- as a control for quantifying serum 3-Hydroxy-DL-kynurenine levels in diabetic retinopathy patients
Definition
ChEBI: A hydroxykynurenine that is kynurenine substituted by a hydroxy group at position 3.
General Description
3-Hydroxy-DL-kynurenine is a tryptophan metabolite with a molecular weight corresponding to 224Da. It is a chromophore or hydrophilic yellow compound present in the lens of the eye. 3-Hydroxy-DL-kynurenine is synthesized from kynurenine?by the action of enzyme kynurenine 3-monooxygenase (KMO). It is metabolized to 3-hydroxyanthranilic acid and xanthurenic acid in the presence of enzymes kynureninase and kynurenine aminotransferases, respectively.
Biochem/physiol Actions
3-Hydroxy-DL-kynurenine (3-HKYN) has antioxidant functionality and prevents lipid peroxidation in cerebral cortex. It may modulate synaptic neurotransmission. The levels of 3-HKYN is elevated in Huntington′s disease. However, its role in neurodegenerative diseases is still not understood well. Kynurenine metabolism is linked with glutamatergic neurotransmission and the level of 3-HKYN is linked to the pathophysiology of schizophrenia.
2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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