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Akebia saponin D

Product Name
Akebia saponin D
CAS No.
39524-08-8
Chemical Name
Akebia saponin D
Synonyms
Asperosap;AkebosideD;AsperosaponinⅥ;Asperosaponin Ⅵ;Asperosaponin VI;Akebia saponin D;Dipsacaceae saponin;Asperosaponin VI-RM;Akebia saponin D USP/EP/BP;Asperosaponin VI (Akeboside D)
CBNumber
CB61267734
Molecular Formula
C47H76O18
Formula Weight
929.1
MOL File
39524-08-8.mol
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Akebia saponin D Property

Melting point:
234-235 °C
Boiling point:
990.2±65.0 °C(Predicted)
Density 
1.43
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
form 
Solid
pka
12.50±0.70(Predicted)
color 
White to Pale Beige
biological source
(Dipsacus asper)
optical activity
[α]/D +13 to +18°, c =0.5 in methanol
Water Solubility 
H2O: 3mg/mL, clear (warmed)
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Safety

Safety Statements 
24/25
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1822
Product name
Akebia saponin D
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$117
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1822
Product name
Akebia saponin D
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$477
Updated
2025/07/31
Sigma-Aldrich
Product number
PHL83275
Product name
Asperosaponin VI
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$437
Updated
2025/07/31
TCI Chemical
Product number
A3635
Product name
Asperosaponin VI
Packaging
100MG
Price
$345
Updated
2025/07/31
TRC
Product number
A788600
Product name
AsperosaponinVI
Packaging
10mg
Price
$150
Updated
2021/12/16
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Akebia saponin D Chemical Properties,Usage,Production

Chemical Properties

Derived from the root of Dipsacus asperoides CY Cheng et T .M. Ai.

Uses

Asperosaponin VI is a steroidal extract with anti-inflammatory and antinociceptive activity. long term use has been seen to attenuate cardiac dysfunction.

Definition

ChEBI: Akebia saponin D is a triterpenoid saponin that is hederagenin attached to a alpha-L-arabinopyranosyl residue at position 3 via a glycosidic linkage and a 6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl residue at position 28 via an ester linkage. It is the active ingredient found in the traditional Chinese herb Radix Dipsaci. It has a role as an apoptosis inducer, an antineoplastic agent, a plant metabolite, an anti-inflammatory agent, a bone density conservation agent, a neuroprotective agent and an antilipemic drug. It is a triterpenoid saponin, a trisaccharide derivative, a pentacyclic triterpenoid and a carboxylic ester. It is functionally related to a hederagenin.

Biological Activity

Akebia saponin D (ASD) is a bioactive triterpenoid saponin isolated from the rhizome of Dipsacus asper Wall th at is used as an anti-osteoporosis drug. Akebia saponin D exhibits therapeutic effects in number of disease models including cancer, Alzheimerμs disease, cardiovascular disease, and bone fractures. Akebia saponin D protects against nonalcoholic fatty liver disease (NAFLD) liver damage in mice model of NAFLD. ASD decreases hepatic steatosis and heptocyte apoptosis through autophagy modulation. Akebia saponin D prevents oleic acid induced lipid droplets accumulation and increases autophagic flux BRL cells.

in vivo

Asperosaponin VI (20 mg/kg; intravenous injection; 3 weeks) can accelerate wound healing and angiogenesis in a full-thickness cutaneous wound model of rats[3].
Asperosaponin VI (40 mg/kg; intraperitoneal injection; 3 weeks) has antidepressant effects in mice with chronic mild stress[4].

Animal Model:Male 8-week-old C57BL/6 mice treated chronic mild stress (CMS)[4]
Dosage:40 mg/kg
Administration:Intraperitoneal injection (i.p.); 3 weeks
Result:Significantly improved depression-like behaviors in CMS-induced mice, as shown by increased sucrose preference, prolonged latency in the forced swimming test and feeding latency in the novelty-suppressed feeding test, and shortened immobility time in the tail suspension test and forced swimming test.
Partially reversed CMS-induced weight loss.
Induced hippocampal microglia to switch from a pro-inflammatory to a neuroprotective phenotype, and regulated the levels of pro-inflammatory and anti-inflammatory cytokines.
Exerted anti-inflammatory and antidepressant effects through PPAR-γ pathway.
Promoted microglia-neuron crosstalk and prevented CMS-induced synaptic dysfunction of hippocampal neurons.

IC 50

Caspase 3

Akebia saponin D Preparation Products And Raw materials

Raw materials

Preparation Products

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Akebia saponin D Suppliers

China 231 India 1 United Kingdom 1 United States 15 Global 248
ZHIWE CHEMTECH CO LTD
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021-20221225 13917446399
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QQ:115820162
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zwchem@163.com
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China
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Chembest Research Laboratories Limited
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+86-21-20908456
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021-58180499
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sales@BioChemBest.com
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China
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Adamas Reagent, Ltd.
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400-6009262 16621234537
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021-64823266
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chenyj@titansci.com
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China
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14101
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Sichuan Kulinan Technology Co., Ltd
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400-1166-196 18981987031
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028-84555506 800101999
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cdhxsj@163.com
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China
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11705
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Shenzhen Sungening Bio-Tech Co., Ltd
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+86-0755-89668383
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+86-0755-89594066/4038
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sales@sungening.com
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China
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1319
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
Email
sales@meilune.com
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China
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4747
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BioBioPha Co., Ltd.
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0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
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China
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5653
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ShangHai YuanYe Biotechnology Co., Ltd.
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021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4999
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Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
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55
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
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View Lastest Price from Akebia saponin D manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Akebia saponin D 39524-08-8
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-09-29
Shanghai Standard Technology Co., Ltd.
Product
Akebia saponin D 39524-08-8
Price
US $0.00/mg
Min. Order
5mg
Purity
Analytical Standard
Supply Ability
10 g
Release date
2019-09-29
Career Henan Chemical Co
Product
Akebia saponin D 39524-08-8
Price
US $2.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10000kg
Release date
2018-08-10

39524-08-8, Akebia saponin DRelated Search:

Pennogenin 3-O-alpha-L-rhamnopyranosyl-(1-2)-beta-D-xylopyranosyl-(1-4)-beta-D-glucopyranoside 4'-O-Acetyl-akebia saponin D Dipsanoside A 3-[[2-O-(α-L-Rhamnopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxyolean-12-en-28-oic acid Dipsanoside B oleanolic acid-3-O-β-D-glucopyranosyl (1→2)-α-L-arabinopyranoside Sylvestroside I dipsacoside B (3beta,25R)-14-Hydroxyspirost-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-[beta-D-xylopyranosyl-(1-4)]-beta-D-glucopyranoside TRIBULOSIDE Saponin

  • Akebia saponin D
  • Asperosaponin VI
  • Hederagenin 3-O-alpha-L-arabinopyranosyl-28-beta-D-glucopyranosyl(1→6)-beta-D-glucopyranoside
  • Akebia saponin D(Asperosaponin VI)
  • Dipsacaceae saponin
  • 3'-Amino-2'-Hydroxy-1,1' biphenyl-3-cAsperosaponin VI
  • Asperosaponin VI, 98%, from Dipsacales
  • Asperosaponin Ⅵ
  • Asperosaponin VI (Akeboside D)
  • AkebosideD
  • Olean-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-23-hydroxy-, 6-O-β-D-glucopyranosyl-β-D-glucopyranosyl ester, (3β,4α)-
  • Akebia saponin D USP/EP/BP
  • TIANFUCHEM--39524-08-8--High purity Akebia saponin D factory price
  • Asperosap
  • 1-O-[(3b)-3-(a-L-Arabinopyranosyloxy)-23-hydroxy-28-oxoolean-12-en-28-yl]-6-O-D-glucopyranosyl-b-D-glucopyranose
  • (2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl (4aS,6aS,6bR,8aR,9R,10S,12aR,12bR,14bS)-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-10-(((2S,3R,4S,5S)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate
  • Asperosaponin VI-RM
  • 3’-Amino-2’-Hydroxy-1,1’ biphenyl-3-cAsperosaponin VI
  • Asperosaponin VI, 10 mM in DMSO
  • AsperosaponinⅥ
  • 39524-08-8
  • C47H76O18
  • Inhibitors
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract