3-IODO-4-METHOXY-PYRIDINE
- Product Name
- 3-IODO-4-METHOXY-PYRIDINE
- CAS No.
- 89640-55-1
- Chemical Name
- 3-IODO-4-METHOXY-PYRIDINE
- Synonyms
- 3-IODO-4-METHOXY-PYRIDINE;Pyridine, 3-iodo-4-methoxy-
- CBNumber
- CB6127420
- Molecular Formula
- C6H6INO
- Formula Weight
- 235.02
- MOL File
- 89640-55-1.mol
3-IODO-4-METHOXY-PYRIDINE Property
- Melting point:
- 78 °C(Solv: ligroine (8032-32-4))
- Boiling point:
- 271.2±25.0 °C(Predicted)
- Density
- 1.825±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 4.52±0.18(Predicted)
- form
- solid
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C6H6INO/c1-9-6-2-3-8-4-5(6)7/h2-4H,1H3
- InChIKey
- WZAPSURIRLYQEJ-UHFFFAOYSA-N
- SMILES
- C1=NC=CC(OC)=C1I
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ADE000651
- Product name
- 3-Iodo-4-methoxypyridine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $817
- Updated
- 2025/07/31
- Product number
- HCH0030628
- Product name
- PYRIDINE, 3-IODO-4-METHOXY-
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $952.88
- Updated
- 2021/12/16
- Product number
- J52664
- Product name
- 3-Iodo-4-methoxypyridine
- Packaging
- 25g
- Price
- $1050
- Updated
- 2021/12/16
- Product number
- 4852AC
- Product name
- 3-Iodo-4-methoxypyridine
- Packaging
- 10g
- Price
- $721
- Updated
- 2021/12/16
- Product number
- 048337
- Product name
- 3-Iodo-4-methoxypyridine
- Packaging
- 1mg
- Price
- $195
- Updated
- 2021/12/16
3-IODO-4-METHOXY-PYRIDINE Chemical Properties,Usage,Production
Synthesis
620-08-6
89640-55-1
The general procedure for the synthesis of 3-iodo-4-methoxypyridine from 4-methoxypyridine was as follows: n-butyllithium (ca. 1.6 M hexane solution, 1.5 mmol) was sequentially added to a stirred solution of 2,2,6,6-tetramethylpiperidine (0.25 mL, 1.5 mmol) in tetrahydrofuran (THF, 2-3 mL) at 0 °C. After 5 min, n-butyllithium (ca. 1.6 M hexane solution, 1.5 mmol) was added. ZnCl2TMEDA complex (0.13 g, 0.50 mmol). The reaction mixture was continued to be stirred at 0 °C for 15 min and then 4-methoxypyridine (1.0 mmol) was added at 0-10 °C. After the reaction mixture was stirred for 2 h at room temperature, a THF (4 mL) solution of iodine (I2, 0.38 g, 1.5 mmol) was added. After the mixture was stirred overnight, the reaction was quenched by the addition of saturated aqueous sodium thiosulfate (Na2S2O3) solution (4 mL) and extracted with ethyl acetate (AcOEt, 320 mL). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. Finally, the target product, 3-iodo-4-methoxypyridine, was purified by silica gel column chromatography (eluent given in the product specification).
References
[1] Tetrahedron, 2016, vol. 72, # 17, p. 2196 - 2205
[2] Tetrahedron, 1993, vol. 49, # 37, p. 8373 - 8380
[3] Tetrahedron Letters, 2011, vol. 52, # 36, p. 4590 - 4594
[4] Chemical Communications, 2014, vol. 50, # 85, p. 12859 - 12862
[5] Chemistry - A European Journal, 2013, vol. 19, # 24, p. 7944 - 7960
3-IODO-4-METHOXY-PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-IODO-4-METHOXY-PYRIDINE manufacturers
- Product
- 3-Iodo-4-methoxypyridine 89640-55-1
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-02