1,3,5-Tribromobenzene Property

Melting point:

117-121 °C (lit.)

Boiling point:

271 °C (lit.)

Density 

2.3515 (estimate)

refractive index 

1.6340 (estimate)

Flash point:

271°C

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Soluble in benzene, chloroform, and ether (Weast, 1986)

form 

Powder

color 

Almost white to orange-brown

Water Solubility 

Soluble in hot ethanol and acetic acid. Insoluble in water.

BRN 

1858917

InChIKey

YWDUZLFWHVQCHY-UHFFFAOYSA-N

CAS DataBase Reference

626-39-1(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1,3,5-tribromo-(626-39-1)

EPA Substance Registry System

1,3,5-Tribromobenzene (626-39-1)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38-53

Safety Statements 

22-24/25-37/39-26

WGK Germany 

3

RTECS 

DC1957200

TSCA 

Yes

HS Code 

29036990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

1,3,5-Tribromobenzene Chemical Properties,Usage,Production

Chemical Properties

Lump powder; Vapour pressure of 1,3,5-tribromobenzene between 295 and 389 K (solid) and 397 and 410 K (liquid). The enthalpies of sublimation and vaporisation were derived from the relationship between vapour pressure and temperature: ΔH°SUB(334.78 K) = 83.54 ± 2 kJ/mol and ΔH°vap(403.23 K) = 58.68 ± 1.5 kJ/mol.

Uses

Intermediate in drug manufacturing; organic synthesis; internal standard in analysis of aqueous samples.

Uses

1,3,5-Tribromobenzene, is a reagent that can be used in the preparation of different inhibitors. It is also a substituted Bromobenzene, a general reagent in palladium-catalyzed reactions and in the synthesis of Grignard reagents.

General Description

• 1,3,5-Tribromobenzene(TBB) acts as internal standard during derivatization step in determination of cyanide in human plasma and urine by gas chromatography-mass spectrometry.
• TBB forms molecular complexes of 1:2 stoichiometry with [60]-and [70] fullerenes.
• TBB reacts with perfluoroalkenylzinc reagent in the presence of Pd(Ph₃)₄ catalyst to yield a novel trifunctional monomer 1,3,5-tris(α, β, β-trifluorovinyl)benzene.

Environmental Fate

Photolytic. Peijnenburg et al. (1992) investigated the photodegradation of a variety of substituted aromatic halides using a Rayonet RPR-208 photoreactor equipped with 8 RUL 3,000- ? lamps (250–350 nm). The reaction of 1,3,5-tribromobenzene (initial concentration 10-5 M) was conducted in distilled water and maintained at 20 °C. Though no products were identified, the investigators reported photohydrolysis was the dominant transformation process. The measured pseudo-first-order reaction rate constant and corresponding half-life were 0.005/min and 140.5 min., respectively.
Chemical/Physical. 1,3,5-Tribromobenzene will not hydrolyze to any reasonable extent.

Purification Methods

Crystallise it from glacial acetic acid/water (4:1), then wash with chilled EtOH and dry in air. [Beilstein 5 H 213, 5 IV 685.]