1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI)

Product Name: 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI)
CAS No.: 288148-34-5
Chemical Name: 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI)
Synonyms: EOS-61290;1-methyl-(9CI);Relacorilant Impurity 2;1-methylpyrazole-4-sulfonyl chloride;1-methyl-4-pyrazolesulfonyl chloride;1-Methyl-1H-pyrazol-4-sulfonyl chloride;4-(Chlorosulphonyl)-1-methyl-1H-pyrazole;1-Methyl-1H-pyrazole-4-sulphonyl chloride;1H-pyrazole-4-sulfonyl chloride, 1-methyl-;1-Methyl-1H-pyrazole-4-sulfonylchloride,97%
CBNumber: CB61297490
Molecular Formula: C4H5ClN2O2S
Formula Weight: 180.61
MOL File: 288148-34-5.mol

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1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI) Property

Boiling point:: 295.7±13.0 °C(Predicted)
Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: crystalline solid
pka: -3.33±0.10(Predicted)
color: White
Sensitive: Moisture Sensitive
InChI: InChI=1S/C4H5ClN2O2S/c1-7-3-4(2-6-7)10(5,8)9/h2-3H,1H3
InChIKey: RDAVKKQKMLINOH-UHFFFAOYSA-N
SMILES: N1(C)C=C(S(Cl)(=O)=O)C=N1

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Safety

Hazard Codes: Xi
Risk Statements: 43
Safety Statements: 36/37
RIDADR: UN3265
WGK Germany: 3
HazardClass: IRRITANT
HazardClass: 8
HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H317May cause an allergic skin reaction
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CBR01513
Product name: 1H-Pyrazole-4-sulfonyl chloride
Purity: Aldrich
Packaging: 1g
Price: $391
Updated: 2024/03/01

TRC

Product number: M342125
Product name: 1-Methyl-1H-pyrazole-4-sulfonylChloride
Packaging: 5g
Price: $130
Updated: 2021/12/16

Oakwood

Product number: 025206
Product name: 1-Methyl-1H-pyrazole-4-sulfonyl chloride
Packaging: 250mg
Price: $20
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H62-5-X0
Product name: 1-Methyl-1H-pyrazole-4-sulfonyl chloride
Packaging: 250mg
Price: $26
Updated: 2021/12/16

Oakwood

Product number: 025206
Product name: 1-Methyl-1H-pyrazole-4-sulfonyl chloride
Packaging: 1g
Price: $30
Updated: 2021/12/16

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1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI) Chemical Properties,Usage,Production

Uses

1-Methyl-1H-pyrazole-4-sulfonyl Chloride is used as a reagent in the preparation of benzoindazoles as glucocorticoid receptor modulators.

Synthesis

930-36-9

288148-34-5

1-Methyl-1H-pyrazole (100 g, 1.18 mol) was slowly added dropwise to chlorosulfonic acid (325 mL, 4.84 mol) at 0 °C and under nitrogen protection, keeping stirring. The reaction mixture was then heated to reflux at 110 °C for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and quenched by careful pouring into crushed ice with continuous stirring. The precipitated white solid product was collected by vacuum filtration and washed well with cold water. Finally, the product was dried under vacuum to afford 1-methyl-1H-pyrazole-4-sulfonyl chloride (72.2 g, 33% yield), which can be used in subsequent reactions without further purification.

References

[1] Patent: WO2009/29439, 2009, A1. Location in patent: Page/Page column 24
[2] Patent: US6103708, 2000, A
[3] Patent: WO2005/97162, 2005, A2. Location in patent: Page/Page column 432

1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI) Suppliers

China 102 Europe 1 India 3 United Kingdom 1 United States 10 Global 117

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View Lastest Price from 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI) manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI) 288148-34-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-04-21

Suzhou Nordica Biopharma CO.,LTD

Product: 1-methyl-1H-pyrazole-4-sulfonyl chloride 288148-34-5
Price: US $0.00-0.00/kg
Min. Order: 0.05kg
Purity: 0.98
Supply Ability: 1 tons
Release date: 2024-11-15

Career Henan Chemical Co

Product: 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI) 288148-34-5
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-15

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