5-Pyrazolecarboxylic acid

Product Name: 5-Pyrazolecarboxylic acid
CAS No.: 1621-91-6
Chemical Name: 5-Pyrazolecarboxylic acid
Synonyms: 1H-PYRAZOLE-3-CARBOXYLIC ACID;PYRAZOLE-3-CARBOXYLIC ACID;Pyrazole-5-carboxylic acid;SKL261;AKOS B000140;AKOS BB-9039;01H-Pyrazole;3- pyrazol formate;ART-CHEM-BB B000140;TIMTEC-BB SBB000005
CBNumber: CB6317652
Molecular Formula: C4H4N2O2
Formula Weight: 112.09
MOL File: 1621-91-6.mol

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5-Pyrazolecarboxylic acid Property

Melting point:: 211°C
Boiling point:: 417.1±18.0 °C(Predicted)
Density: 1.524±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
pka: 3.98±0.10(Predicted)
form: Powder
color: White
λmax: 260nm(MeOH)(lit.)
InChI: InChI=1S/C4H4N2O2/c7-4(8)3-1-2-5-6-3/h1-2H,(H,5,6)(H,7,8)
InChIKey: KOPFEFZSAMLEHK-UHFFFAOYSA-N
SMILES: N1C=CC(C(O)=O)=N1
CAS DataBase Reference: 1621-91-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 38
Safety Statements: 24/25
HazardClass: IRRITANT
HS Code: 29331990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 707384
Product name: 1H-Pyrazole-3-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $27.44
Updated: 2025/07/31

TCI Chemical

Product number: P1862
Product name: Pyrazole-3-carboxylic Acid
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: P1862
Product name: Pyrazole-3-carboxylic Acid
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $104
Updated: 2025/07/31

TRC

Product number: B529765
Product name: 1H-Pyrazole-3-carboxylic acid
Packaging: 250mg
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H21-1-G7
Product name: 1H-Pyrazole-3-carboxylic acid
Packaging: 5G
Price: $48
Updated: 2021/12/16

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5-Pyrazolecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White to light brown powder

Uses

1H-pyrazole-3-carboxylic Acid is a histone lysine demethylase KDM4C and proline racemase inhibitor.

Synthesis

1453-58-3

1621-91-6

The general procedure for the synthesis of pyrazole-3-carboxylic acid from 3-methylpyrazole was as follows: an aqueous solution of potassium permanganate (KMnO4, 40.9 g, 0.26 mol) was slowly added to a stirring solution of 3-methyl-1H-pyrazole (9.8 mL, 0.12 mol) dissolved in 0.5 L of water. The reaction mixture was heated to reflux and maintained for 5 hours. After completion of the reaction, the black suspension was cooled and filtered. The filtrate was concentrated to a smaller volume and acidified with 3 N hydrochloric acid (HCl). Subsequently, the precipitated white solid product was collected and washed with ethyl ether (Et2O) to give the final pyrazole-3-carboxylic acid in 100% yield.

References

[1] Journal of the American Chemical Society, 2000, vol. 122, # 44, p. 10810 - 10820
[2] Patent: WO2004/80999, 2004, A1. Location in patent: Page 43
[3] Russian Journal of Physical Chemistry, 1992, vol. 66, # 4, p. 463 - 465
[4] Zhurnal Fizicheskoi Khimii, 1992, vol. 66, # 4, p. 871 - 874
[5] Organic Mass Spectrometry, 1982, vol. 17, # 7, p. 299 - 303

5-Pyrazolecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Pyrazolecarboxylic acid Suppliers

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View Lastest Price from 5-Pyrazolecarboxylic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-Pyrazolecarboxylic acid 1621-91-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-29

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-Pyrazolecarboxylic acid 1621-91-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-30

Hebei Chuanghai Biotechnology Co,.LTD

Product: 5-Pyrazolecarboxylic Acid 1621-91-6
Price: US $10.70/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-23

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ART-CHEM-BB B000140

1H-PYRAZOLE-3-CARBOXYLIC ACID

1H-Pyrazole-3-carboxylic acid 97%

Pyrazole-5-carboxylic acid

AKOS BB-9039

AKOS B000140

5-PYRAZOLECARBOXYLIC ACID

3-PYRAZOLECARBOXYLIC ACID

PYRAZOLE-3-CARBOXYLIC ACID

TIMTEC-BB SBB000005

Pyrazole-3-carboxylicAcid&gt

3- pyrazol formate

SKL261

Pyrazole-3-carboxylic acid (8CI)

1H-Pyrazol-3-carboxylic acid

Pyrazole-3-carboxylicAci

3-Carboxy-1H-pyrazole

1H-Pyrazole-3-carboxylic acid, 10 mM in DMSO

2<i>H</i>-Pyrazole-3-carboxylic acid

1<i>H</i>-Pyrazole-3-carboxylic acid

1621-91-6

7970227-83-9

Acids and Derivatives

Heterocycles

Pyrazole series

API intermediates