ChemicalBook > CAS DataBase List > 5-Pyrazolecarboxylic acid

5-Pyrazolecarboxylic acid

Product Name
5-Pyrazolecarboxylic acid
CAS No.
1621-91-6
Chemical Name
5-Pyrazolecarboxylic acid
Synonyms
1H-PYRAZOLE-3-CARBOXYLIC ACID;PYRAZOLE-3-CARBOXYLIC ACID;Pyrazole-5-carboxylic acid;SKL261;AKOS B000140;AKOS BB-9039;01H-Pyrazole;3- pyrazol formate;ART-CHEM-BB B000140;TIMTEC-BB SBB000005
CBNumber
CB6317652
Molecular Formula
C4H4N2O2
Formula Weight
112.09
MOL File
1621-91-6.mol
More
Less

5-Pyrazolecarboxylic acid Property

Melting point:
211°C
Boiling point:
417.1±18.0 °C(Predicted)
Density 
1.524±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
3.98±0.10(Predicted)
form 
Powder
color 
White
λmax
260nm(MeOH)(lit.)
InChI
InChI=1S/C4H4N2O2/c7-4(8)3-1-2-5-6-3/h1-2H,(H,5,6)(H,7,8)
InChIKey
KOPFEFZSAMLEHK-UHFFFAOYSA-N
SMILES
N1C=CC(C(O)=O)=N1
CAS DataBase Reference
1621-91-6(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
38
Safety Statements 
24/25
HazardClass 
IRRITANT
HS Code 
29331990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
707384
Product name
1H-Pyrazole-3-carboxylic acid
Purity
97%
Packaging
1g
Price
$27.44
Updated
2025/07/31
TCI Chemical
Product number
P1862
Product name
Pyrazole-3-carboxylic Acid
Purity
>98.0%(HPLC)
Packaging
1g
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
P1862
Product name
Pyrazole-3-carboxylic Acid
Purity
>98.0%(HPLC)
Packaging
5g
Price
$104
Updated
2025/07/31
TRC
Product number
B529765
Product name
1H-Pyrazole-3-carboxylic acid
Packaging
250mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
008021
Product name
1H-Pyrazole-3-carboxylic acid
Packaging
1g
Price
$10
Updated
2021/12/16
More
Less

5-Pyrazolecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White to light brown powder

Uses

1H-pyrazole-3-carboxylic Acid is a histone lysine demethylase KDM4C and proline racemase inhibitor.

Synthesis

1453-58-3

1621-91-6

The general procedure for the synthesis of pyrazole-3-carboxylic acid from 3-methylpyrazole was as follows: an aqueous solution of potassium permanganate (KMnO4, 40.9 g, 0.26 mol) was slowly added to a stirring solution of 3-methyl-1H-pyrazole (9.8 mL, 0.12 mol) dissolved in 0.5 L of water. The reaction mixture was heated to reflux and maintained for 5 hours. After completion of the reaction, the black suspension was cooled and filtered. The filtrate was concentrated to a smaller volume and acidified with 3 N hydrochloric acid (HCl). Subsequently, the precipitated white solid product was collected and washed with ethyl ether (Et2O) to give the final pyrazole-3-carboxylic acid in 100% yield.

References

[1] Journal of the American Chemical Society, 2000, vol. 122, # 44, p. 10810 - 10820
[2] Patent: WO2004/80999, 2004, A1. Location in patent: Page 43
[3] Russian Journal of Physical Chemistry, 1992, vol. 66, # 4, p. 463 - 465
[4] Zhurnal Fizicheskoi Khimii, 1992, vol. 66, # 4, p. 871 - 874
[5] Organic Mass Spectrometry, 1982, vol. 17, # 7, p. 299 - 303

5-Pyrazolecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5-Pyrazolecarboxylic acid Suppliers

Americas 1 Belgium 1 China 256 Czech Republic 1 Europe 1 France 1 Germany 6 Hungary 1 India 9 Japan 2 Russia 3 South Korea 1 Switzerland 3 The Netherlands 1 United Kingdom 10 United States 44 Global 341
Jinan Liheng Biotechnology Co., Ltd.
Tel
0531-18763987518 18763987518
Email
levi@lihengpharm.com
Country
China
ProdList
1797
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Yangzhou Siyu Chemical Co.,Ltd.
Tel
0514-87325867
Fax
0086-514-87325867
Email
sales@siyuchem.com
Country
China
ProdList
370
Advantage
55
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
ChemFuture PharmaTech (Jiangsu) Ltd
Tel
5108538618
Fax
86 510 85386988-8017
Email
suger.wang@chemfuture.com
Country
China
ProdList
832
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
Advantage
64
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
ZEROSCHEM.CO.,LTD.
Tel
10-61256048 13810278579
Fax
+86 10 61256049
Email
sales@zeroschem.com
Country
China
ProdList
1371
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Record Tech (Shanghai) Co., LTD
Tel
13761627472
Fax
86-21-64965863
Email
183009664@qq.com
Country
China
ProdList
649
Advantage
62
Tangshan Moneide Trading Co., Ltd.
Tel
0315-8309571 15633399667
Fax
+86-315-7726572
Email
sales@moneidechem.com
Country
China
ProdList
704
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Heterochem
Tel
027-88041443 13072715837
Fax
027-51829379
Email
sales@hetero-chem.com
Country
China
ProdList
696
Advantage
58
Acorn PharmaTech Co., Ltd.
Tel
025-58395930
Fax
025-5861-9182
Email
sales@acornpharma.com
Country
China
ProdList
982
Advantage
60
Shanghai Xiannuo Biotechnology Co., Ltd.
Tel
021-50718719 13918719472
Fax
021-50718719
Country
China
ProdList
979
Advantage
58
Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.
Tel
022-60116533 13207668525
Fax
022-60979672
Email
saleskc@scipharmacn.com
Country
China
ProdList
603
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Suzhou Sibian Chemical Technology Co.,Ltd.
Tel
0512-65617459 18915409046
Fax
0512-65617459
Email
sales@sibian-chem.com
Country
China
ProdList
1922
Advantage
55
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Baiyin Chengze Chemical Technology Co., Ltd.
Tel
+86 943-8535351 13389336721
Fax
+86-943-8535351
Email
sales@chengzechem.com
Country
China
ProdList
289
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
shanghai cooperpharm co.,LTD .
Tel
+86-021-58975553
Fax
+86-021-58975554
Email
sales@cooperpharm.com
Country
China
ProdList
1210
Advantage
56
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Shanghai Huikai Chemical Technology Co., Ltd.
Tel
021-61995394 18916691159
Email
chemicalsea@163.com
Country
China
ProdList
1972
Advantage
58
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3930
Advantage
58
BEIJING TDVINO TECHNOLOGY CO.,LTD
Tel
010-56371379
Fax
010-56371379
Country
China
ProdList
99
Advantage
55
Chimica Laboratories Co., Ltd
Tel
0086-573-82585213
Fax
0086-573-82585233
Email
bai@chimicalabs.com
Country
China
ProdList
861
Advantage
64
Shanghai Hong-chuang Pharma Tech Co., Ltd.
Tel
18151128828
Fax
-
Email
hc-sales@foxmail.com
Country
China
ProdList
2647
Advantage
55
Shanghai Hekang Biotechnology Co., Ltd.
Tel
18939837085
Fax
2880152141(QQ)
Email
youchemicals@gmail.com
Country
China
ProdList
1839
Advantage
55
HuBei ShengBaoLai Biological Technology Co., Ltd
Tel
027-59105235 13007105135
Fax
027-59105235
Email
sbl1120@163.com
Country
China
ProdList
100
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Country
China
ProdList
2930
Advantage
58
More
Less

View Lastest Price from 5-Pyrazolecarboxylic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
5-Pyrazolecarboxylic acid 1621-91-6
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-06-29
Hebei Chuanghai Biotechnology Co., Ltd
Product
5-Pyrazolecarboxylic acid 1621-91-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-30
Hebei Chuanghai Biotechnology Co,.LTD
Product
5-Pyrazolecarboxylic Acid 1621-91-6
Price
US $10.70/kg
Min. Order
10kg
Purity
99%
Supply Ability
10000kg
Release date
2024-08-23

1621-91-6, 5-Pyrazolecarboxylic acidRelated Search:

Pyraclostrobin Pyrazole Zolpidem tartrate EPA 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Ethyl 2-(Chlorosulfonyl)acetate Folic acid Metazachlor 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI) Ammonium 1-pyrrolidinedithiocarbamate Phenylboronic acid Mandelic acid Pyrazinoic acid hydrazide Citric acid Ascoric Acid Dimethyl 1H-pyrazole-3,5-dicarboxylate 3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE)-PYRAZOLE 4-CYANOPYRAZOLE

  • 1H-Pyrazole-3-carboxylic acid ,98％
  • 01H-Pyrazole
  • 1H-pyrazole-3-carboxylic acid(SALTDATA: FREE)
  • 3-Carboxy-1H-pyrazole, 2H-Pyrazole-5-carboxylic acid
  • Pyrazole - 3 - forMic acid
  • ART-CHEM-BB B000140
  • 1H-PYRAZOLE-3-CARBOXYLIC ACID
  • 1H-Pyrazole-3-carboxylic acid 97%
  • Pyrazole-5-carboxylic acid
  • AKOS BB-9039
  • AKOS B000140
  • 5-PYRAZOLECARBOXYLIC ACID
  • 3-PYRAZOLECARBOXYLIC ACID
  • PYRAZOLE-3-CARBOXYLIC ACID
  • TIMTEC-BB SBB000005
  • Pyrazole-3-carboxylicAcid&gt
  • 3- pyrazol formate
  • SKL261
  • Pyrazole-3-carboxylic acid (8CI)
  • 1H-Pyrazol-3-carboxylic acid
  • Pyrazole-3-carboxylicAci
  • 3-Carboxy-1H-pyrazole
  • 1H-Pyrazole-3-carboxylic acid, 10 mM in DMSO
  • 2<i>H</i>-Pyrazole-3-carboxylic acid
  • 1<i>H</i>-Pyrazole-3-carboxylic acid
  • 1621-91-6
  • 7970227-83-9
  • Acids and Derivatives
  • Heterocycles
  • Pyrazole series
  • API intermediates